University Of Manchester

This trial tests a new way to do stem cell transplants for young adults (ages 16-55) with very aggressive acute myeloid leukemia that hasn't responded to chemo or has high-risk gene changes. Participants get a transplant using umbilical cord blood plus extra infusions of white bl…

This study looks at whether it is possible to run a larger trial that offers bereavement counselling to parents who have lost a baby during pregnancy or shortly after birth. About 26 parents will be randomly assigned to receive either standard hospital bereavement care or standar…

This small study will test if a culturally-adapted form of cognitive-behavioural therapy (CBT) is practical, acceptable, and safe for Black Sub-Saharan African and Caribbean people who experience psychosis. Six participants will attend up to 16 therapy sessions and complete quest…

This study tests whether a short planning exercise can help healthcare professionals raise and respond to patient safety concerns. About 1,000 healthcare workers will complete online surveys and be randomly assigned to either do the planning exercise or not. Researchers will chec…

This study tests whether making IF-THEN plans helps patients raise safety concerns in healthcare. 10,000 adults will be randomly assigned to either form these plans online or not. Researchers will track how often participants speak up over 12 months.

This study looks at why the heart medication mavacamten works better for some people with hypertrophic cardiomyopathy (a thickened heart muscle) than others. Researchers will check if a person's specific gene that causes the condition, and their natural ability to process drugs, …

This study looks at whether infertility or IVF treatments are linked to heart and blood vessel problems in women. Researchers will recruit 120 women planning pregnancy (with or without IVF) and compare their heart and metabolic health. The goal is to understand any connections an…