University Of Manchester

This trial tests a new way to do cord blood transplants for young adults (ages 16-55) with very poor risk acute myeloid leukemia (AML). Participants get a standard cord blood transplant plus daily infusions of white blood cells called granulocytes for 1 to 7 days. The goal is to …

This study looks at whether offering bereavement counselling to parents who have lost a baby (after 16 weeks of pregnancy or shortly after birth) is practical and helpful. About 26 parents will either receive usual hospital bereavement care or get extra counselling. Researchers w…

This small study will test if a culturally-adapted form of cognitive-behavioural therapy (CBT) is practical, acceptable, and safe for Black Sub-Saharan African and Caribbean people who experience psychosis. Six participants will attend up to 16 therapy sessions and complete quest…

This study will check the heart and blood vessel health of 120 women, some planning pregnancy naturally and some after IVF for infertility. Researchers want to see if infertility or IVF treatments are linked to higher heart disease risk. The goal is to learn how to run a larger s…

This study tests whether a short planning exercise can help healthcare professionals raise and respond to patient safety concerns. About 1,000 healthcare workers will complete online questionnaires and be randomly assigned to either do the planning exercise or not. Follow-ups at …

This study tests whether making IF-THEN plans helps patients speak up about safety concerns in healthcare. 10,000 adults will be randomly assigned to either make these plans online or not. Researchers will track how often participants report raising safety concerns over the next …

This study aims to find out why the heart medication mavacamten works better for some people with hypertrophic cardiomyopathy (a condition where the heart muscle is too thick) than for others. Researchers will look at participants' genes, including the specific gene causing their…

This study looks at whether a new medication (mavacamten) can improve the energy levels of the heart muscle in people with obstructive hypertrophic cardiomyopathy, a condition where the heart wall thickens and blocks blood flow. Researchers will use a special MRI scan to measure …