Could white blood cells boost cord transplants for tough leukemia?
NCT ID NCT07372885
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial tests a new way to do cord blood transplants for young adults (ages 16-55) with very poor risk acute myeloid leukemia (AML). Participants get a standard cord blood transplant plus daily infusions of white blood cells called granulocytes for 1 to 7 days. The goal is to see if this combination is safe and can reduce the chance of the leukemia coming back. The study has two parts: first to find the best dose, then to see if it works better than standard transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cord blood stem cells and granulocytes (white blood cells)
- What this could lead to
- If successful, this approach could offer a more effective transplant option for young adults with hard-to-treat AML, potentially reducing relapse and improving survival.
- What could go wrong
- This is an early phase I/II trial with only 50 participants, so results may not apply broadly. The granulocyte infusions can cause fever, rash, and other side effects, and the treatment may not work for everyone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kings College Hospital NHS Trust
London, United Kingdom
-
The Christie NHS Foundation Trust
Manchester, United Kingdom
-
The Royal Marsden Hospital NHS Foundation Trust
London, United Kingdom
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