Grape and olive supplement shows promise against arthritis inflammation

NCT ID NCT02566798

Completed Symptom relief Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joint fluid samples. The goal is to find a natural way to manage osteoarthritis inflammation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: grape and olive extract (Oléogrape®SEED)
What this could lead to: If it works, this could point toward a natural supplement that eases inflammation in osteoarthritis, potentially reducing pain and slowing joint damage.
What could go wrong: This is a very small, early study with only 12 people, lasting just 7 days. It measures lab markers, not actual symptom relief, so results may not translate to real-world benefits.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS

Contacts and locations

Locations

CHU de Nantes

Nantes, 44093, France

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