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Knee replacement recovery: why some still feel pain

NCT ID NCT07410884

Knowledge-focused Sponsor: Prefectural University of Hiroshima Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 285 adults who had knee replacement surgery for osteoarthritis. Researchers wanted to see how knee pain and the way people perceive their knee (like feeling it's less familiar or harder to control) are linked over time. Participants filled out questionnaires before surgery and at several points up to a year after. The goal is to find factors that might explain why some people still have pain after surgery, which could lead to better rehab approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could point to new rehabilitation strategies that target body perception to reduce persistent pain after knee replacement.
What could go wrong
This is an observational study, not a treatment trial. It only measures associations and cannot prove cause and effect. Results may not lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

285 people

The number who actually took part.

Started

Oct 2019

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adults with knee osteoarthritis who are scheduled to undergo primary total knee arthroplasty at Fukuoka Orthopaedic Hospital. Participants are recruited consecutively from routine clinical practice and followed from the preoperative period through 12 months after surgery. Individuals are eligible if they can understand and complete study questionnaires and provide written informed consent. Key exclusions include prior surgery on the affected knee, significant neurological or cognitive impairment, rheumatoid arthritis, predominantly lateral compartment knee osteoarthritis, or planned unicompartmental knee arthroplasty.

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * undergoing primary TKA for knee OA * ability to understand and complete study questionnaires * provision of informed consent. Exclusion Criteria: * prior knee surgery on the affected knee * significant neurological or cognitive impairment * diagnosis of rheumatoid arthritis * having undergone unicompartmental knee arthroplasty (UKA).

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthroplasty, total Knee osteoarthristis

Contacts and locations

Locations

  • Prefectural University of Hiroshima

    Mihara, 725-0053, Japan

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