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Simple blood test may predict knee stiffness after replacement

NCT ID NCT03598829

Completed Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study from the Mayo Clinic looked at 219 people getting total knee replacements to see if a blood test measuring an enzyme called tryptase could predict knee stiffness (arthrofibrosis) after surgery. Researchers measured tryptase levels before and after surgery and checked if higher levels were linked to more stiffness and pain. The goal is to find a simple way to identify patients at risk for this common complication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple blood test to identify patients at higher risk for knee stiffness after replacement surgery, allowing for earlier treatment.
What could go wrong
This is an observational study, not a treatment trial. The blood test may not reliably predict stiffness, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHROFIBROSIS ARTHROPATHY OF KNEE KNEE OSTEOARTHRITIS

Contacts and locations

Locations

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

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