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Can a shot of your own blood ease arthritic knees?

NCT ID NCT07828561

Symptom relief Sponsor: KIST Medical and Teaching Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers are studying whether injecting platelet-rich plasma (PRP), a concentrated mix made from a patient's own blood, into the knee can reduce pain and improve movement in people with moderate knee osteoarthritis. The study enrolls adults over 50 with persistent knee pain and X-ray evidence of grade 2 or 3 arthritis who have already tried conservative treatment. Participants receive a single PRP injection and researchers track their pain and function scores over six months, along with any side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) made from the patient's own blood
What this could lead to
If it helps, PRP injections could offer a way to ease knee arthritis pain using a person's own blood instead of surgery or long-term painkillers.
What could go wrong
This is a small, single-arm study with no comparison group, so any improvements could reflect placebo effects or natural ups and downs in arthritis pain. Results may not apply to other patients or to longer time frames.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

59 people

The number who actually took part.

Started

Nov 2022

Finished

Nov 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>50 years * Persistent knee pain \>4 weeks (In the case of patients presenting with bilateral knee pain, the knee with more severe symptoms was selected for study purposes.) * Patient must have undergone conservative treatment for at least 4 weeks. * Radiologically diagnosed as knee osteoarthritis with Kellgren-Lawrence grading scale, grades 2 and 3 * Primary osteoarthritis of the knee Exclusion Criteria: * Immunosuppressed patients (Examples: uncontrolled diabetes, HIV, under corticosteroid medication, etc.) * History of surgery around the knee joint * History of significant knee injury * Patients diagnosed with connective tissue disorders, inflammatory disorders of joints, congenital anomalies of the lower extremity, tumors, and metabolic diseases of bone * Patients who had received intra-articular steroid injections within the past 6 months * Patient who has not attempted conservative treatment. * Presence or suspected of infection or ulceration at the injection site. * Patients with a platelet count less than 1.5 lakhs/microliters * Congenital anomalies of the lower extremity * Patients on NSAIDs 2 days before and 2 days after PRP injection. * Patients with coexisting backache, hip pain * Pregnant or lactating females. * Cases where the diagnosis is uncertain. * Patients not willing to participate in the study

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Degenerative joint disease of knee Knee osteoarthritis Knee pain Osteoarthritis (OA)

Contacts and locations

Locations

  • KIST Medical College and Teaching Hospital

    Lalitpur, Nepal

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