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Custom knee guides put to the test in obese patients

NCT ID NCT02177227

Symptom relief Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers are comparing two ways to perform total knee replacement in patients with obesity and knee arthritis. One method uses custom-made guides based on each patient's knee scans, while the other uses standard surgical tools. The trial measures how well the knee aligns, how long surgery and hospital stays last, and whether the custom approach is worth the cost.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
patient-specific instrumentation for total knee replacement
What this could lead to
If it works, custom-made guides could help surgeons place knee implants more accurately in obese patients, possibly leading to better function and lower costs.
What could go wrong
This is a single study of 194 people. Custom instruments may not improve alignment or recovery compared with standard tools, and they could add cost without clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

194 people

The number who actually took part.

Started

Aug 2014

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients with body mass index (BMI; kg/m2) greater than 30 and less than or equal to 50 * Symptomatic knee osteoarthritis deemed most appropriately treated with total knee arthroplasty * Patient greater than 19 and less than or equal to 70 years of age * English-speaking Exclusion Criteria: * History of prior open knee surgery, infection, or previous knee trauma * Simultaneous bilateral knee arthroplasty * Underlying dementia, cognitive delay, any disorder, or geographic distance that would preclude the completion of the clinical questionnaires * Inflammatory arthropathy * Chronic pain syndrome * Fibromyalgia

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Osteoarthritis

Contacts and locations

Locations

  • London Health Sciences Centre, University Hospital

    London, Ontario, N6A 5A5, Canada

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