New gel injection could ease knee pain for months

NCT ID NCT05978180

Completed Symptom relief Sponsor: Labrha Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a gel called Pandora, made of hyaluronic acid and tranexamic acid, injected into the knee to reduce pain and improve movement in people with knee osteoarthritis. 252 adults aged 35–85 with moderate knee arthritis received either one injection, three weekly injections of Pandora gel, or a standard single injection of a similar product. The goal was to see which approach works best for walking pain over 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Pandora gel (hyaluronic acid with tranexamic acid)

What this could lead to

If it works, this could offer a more effective or longer-lasting option for reducing knee pain and improving mobility in people with knee osteoarthritis.

What could go wrong

This is a completed trial comparing different injection schedules, not a new breakthrough. The gel is similar to existing treatments, so major improvements are unlikely. Results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

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Locations

Cabinet Médical

Montélimar, France
Cabinet Médical

Puyricard, France
Cabinet Médical

Saint-Paul-lès-Dax, France
Cabinet Médical Borely Mermoz

Marseille, France
Cabinet Médical Pluridisciplinaire Wallach

Mulhouse, France
Cabinet Médical Tilsitt

Lyon, France
Cabinet de Rhumatologie

Annecy, France
Cabinet de Rhumatologie

Bagnols-sur-Cèze, France
Cabinet de Rhumatologie

Castelnaudary, France
Cabinet de Rhumatologie

Gourdon, France
Cabinet de Rhumatologie

Mâcon, France
Cabinet de Rhumatologie

Montpellier, France
Cabinet de Rhumatologie

Nîmes, France
Cabinet de Rhumatologie

Roanne, France
Cabinet de Rhumatologie

Villeurbanne, France
Cabinet de Rhumatologie

Viry-Châtillon, France
Cabinet de Rhumatologie La Savoureuse

Belfort, France
Cabinet de Rhumatologie de Palente

Besançon, France
Centre Médical Dulac

La Ciotat, France
Centre Médical Saint Roch

Montpellier, France
Centre Médico-Social du Lac

Mantes-la-Jolie, France
Centre Orthopédique Santy

Lyon, France
Centre de Chirurgie Orthopédique du Beaujolais

Arnas, France
Centre de Médecine du Sport du Beaujolais

Arnas, France
Centre de Rhumatologie Nord Isère

Bourgoin, France
Clinique Saint Charles

Lyon, France
Clinique de la Sauvegarde

Lyon, France
Clinique du Ter

Ploemeur, France
Groupe Hospitalier de la Haute Saône - Hôpital de Vesoul

Vesoul, France
Groupe Médical Adhémar

Montélimar, France
Groupe Médical Spécialisé - Le Premium

Strasbourg, France
Hôpital Nord Franche Comté

Belfort, France
IM2S

Monaco, Monaco
Polyclinique des Alpes du Sud

Gap, France
Pôle de santé des Sept Chemins

Vourles, France