New gel injection could ease knee pain for months
NCT ID NCT05978180
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a gel called Pandora, made of hyaluronic acid and tranexamic acid, injected into the knee to reduce pain and improve movement in people with knee osteoarthritis. 252 adults aged 35–85 with moderate knee arthritis received either one injection, three weekly injections of Pandora gel, or a standard single injection of a similar product. The goal was to see which approach works best for walking pain over 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pandora gel (hyaluronic acid with tranexamic acid)
- What this could lead to
- If it works, this could offer a more effective or longer-lasting option for reducing knee pain and improving mobility in people with knee osteoarthritis.
- What could go wrong
- This is a completed trial comparing different injection schedules, not a new breakthrough. The gel is similar to existing treatments, so major improvements are unlikely. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cabinet Médical
Montélimar, France
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Cabinet Médical
Puyricard, France
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Cabinet Médical
Saint-Paul-lès-Dax, France
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Cabinet Médical Borely Mermoz
Marseille, France
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Cabinet Médical Pluridisciplinaire Wallach
Mulhouse, France
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Cabinet Médical Tilsitt
Lyon, France
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Cabinet de Rhumatologie
Annecy, France
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Cabinet de Rhumatologie
Bagnols-sur-Cèze, France
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Cabinet de Rhumatologie
Castelnaudary, France
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Cabinet de Rhumatologie
Gourdon, France
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Cabinet de Rhumatologie
Mâcon, France
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Cabinet de Rhumatologie
Montpellier, France
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Cabinet de Rhumatologie
Nîmes, France
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Cabinet de Rhumatologie
Roanne, France
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Cabinet de Rhumatologie
Villeurbanne, France
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Cabinet de Rhumatologie
Viry-Châtillon, France
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Cabinet de Rhumatologie La Savoureuse
Belfort, France
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Cabinet de Rhumatologie de Palente
Besançon, France
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Centre Médical Dulac
La Ciotat, France
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Centre Médical Saint Roch
Montpellier, France
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Centre Médico-Social du Lac
Mantes-la-Jolie, France
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Centre Orthopédique Santy
Lyon, France
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Centre de Chirurgie Orthopédique du Beaujolais
Arnas, France
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Centre de Médecine du Sport du Beaujolais
Arnas, France
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Centre de Rhumatologie Nord Isère
Bourgoin, France
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Clinique Saint Charles
Lyon, France
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Clinique de la Sauvegarde
Lyon, France
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Clinique du Ter
Ploemeur, France
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Groupe Hospitalier de la Haute Saône - Hôpital de Vesoul
Vesoul, France
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Groupe Médical Adhémar
Montélimar, France
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Groupe Médical Spécialisé - Le Premium
Strasbourg, France
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Hôpital Nord Franche Comté
Belfort, France
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IM2S
Monaco, Monaco
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Polyclinique des Alpes du Sud
Gap, France
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Pôle de santé des Sept Chemins
Vourles, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Low-Carb diet ease knee pain? a study investigates racial differences
- Blocking knee blood vessels may offer new pain relief for severe osteoarthritis
- Which knee implant lasts longer? a Head-to-Head test
- Can cutting carbs curb knee pain? a diet trial puts it to the test
- Can virtual reality make knee pain therapy more engaging?
- Can a stem cell shot rebuild Worn-Out knees?