Knee replacement patients get extra pain relief from bone injection of morphine?
NCT ID NCT06716749
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether adding morphine to a standard antibiotic injection into the shin bone during knee replacement surgery reduces pain afterward. About 100 adults having their first knee replacement took part. Half got morphine with the antibiotic, half got a placebo. Researchers measured pain scores and how much pain medication patients needed after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Morphine
What this could lead to
If it works, this could offer a simple way to reduce pain after knee replacement without extra pills.
What could go wrong
This is a small, early-phase study. The benefit may be small or not apply to all patients, and morphine can cause nausea or vomiting.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Carilion Clinic
Roanoke, Virginia, 24014, United States