KNEE OSTEOARTHRITIS

This early-stage study tests whether a single injection of a patient's own stem cells into the knee is safe and can reduce pain and improve function in 16 people with knee osteoarthritis or cartilage defects. Participants undergo a bone marrow harvest, then receive the stem cell …

This study looks at how well a partial knee replacement device called MOTO Medial® works for people with knee arthritis. About 269 adults with arthritis in the inner part of the knee will get the implant and be followed for several years. Researchers will measure pain, movement, …

This study looks at whether robotically-assisted partial knee replacement leads to better pain scores and recovery compared to standard total knee replacement. About 95 adults with knee osteoarthritis will use a smartphone app to report pain and opioid use weekly. The goal is to …

This study looks at how stable a new type of knee replacement implant is over time. 31 people with knee arthritis who need a knee replacement will get the implant and be followed for 2 years. The main goal is to see if the implant stays firmly in place using special X-ray measure…

This study tests a robotic knee exoskeleton called Keeogo in 32 veterans with knee osteoarthritis. The device helps support the knees during walking, standing, and stair climbing. Researchers compare it to standard knee braces to see if it improves mobility, reduces pain, and is …

This study tests whether a device that stimulates nerves near the spine (dorsal root ganglion) can reduce chronic knee pain caused by osteoarthritis. About 30 adults with long-term knee pain who have not had surgery or are not good candidates for it will receive the implant. The …

This study aimed to see if a short course of steroids after knee replacement surgery could improve pain, movement, and sleep while reducing the need for strong painkillers. It was designed for adults having their first knee replacement, but the study was withdrawn before any part…

This study compares two types of exercise—core stability exercises and ankle/foot strengthening—to see which better reduces pain and improves function in people with knee osteoarthritis. About 100 adults aged 40 and older with moderate knee osteoarthritis will participate. The go…

This study tests whether using a non-immersive virtual reality system at home can help reduce knee pain from osteoarthritis. Fifty adults aged 45 and older will either play VR physiotherapy games or follow standard care for 12 weeks. The main goal is to see if this approach is pr…

This study tests whether a single injection of stem cells (ELIXCYTE) into the knee can reduce pain and improve function in people with knee osteoarthritis. About 165 adults aged 40 to 80 with moderate knee OA will receive either the stem cell shot or a placebo (salt water). Resea…

This study compares two ultrasound-guided procedures for people with knee osteoarthritis who haven't gotten relief from standard treatments like medication or physical therapy. One method uses a chemical called phenol to block pain signals for a longer time, while the other uses …

This study tests a simple goal-setting tool for people with knee pain or injury who are seeing an orthopedic surgeon. The tool helps patients identify specific, measurable, and time-bound goals for their treatment. The goal is to improve shared decision-making and make sure patie…

This study looks at whether imagining exercises or watching exercise videos can help people feel less pain, move better, and be less afraid of moving after knee replacement surgery. About 36 adults who have had a knee replaced will be split into three groups: standard physical th…

This study was designed to see if an artificial intelligence (AI) mobile app could help people with knee osteoarthritis do their home exercises better. It planned to compare two groups: one using the AI app for real-time feedback and another using a paper booklet. The goal was to…

This study tests a treatment called biofiller PRP for people with knee osteoarthritis. It aims to see if this injection can reduce pain, improve movement, and even thicken knee cartilage. About 60 adults aged 45-65 with moderate knee arthritis will take part. The results will be …

This early-stage study tests the safety of an experimental injection called Allocetra-OTS for people with severe knee osteoarthritis who are considering surgery. The treatment is given directly into the knee joint. The main goal is to see if it is safe, but researchers will also …

This study looks at whether combining two types of gentle exercises—Feldenkrais and active release—can help people with knee osteoarthritis feel less pain and move better. Forty adults aged 40-60 with mild to moderate knee pain took part. The goal is to see if these exercises imp…

This study looks at whether injections of platelet-rich plasma (PRP), made from a patient's own blood, can reduce pain and improve leg function in people with knee osteoarthritis. About 110 adults over age 35 with knee arthritis are taking part. The goal is to see which PRP metho…

This study looks at whether taking a probiotic supplement for 6 months can reduce pain, improve knee function, and boost quality of life in women with knee osteoarthritis. Researchers will compare the probiotic group to a placebo group to see if changes in gut bacteria can lower …

This study tests whether genicular artery embolization (GAE) can safely reduce knee pain from osteoarthritis. The procedure uses tiny beads injected through a pinhole in the thigh to block abnormal blood flow that fuels inflammation. About 100 adults with moderate-to-severe knee …

This study tests a new procedure called genicular artery embolization (GAE) against standard steroid injections for people with painful knee osteoarthritis. About 264 adults with mild to severe knee pain that hasn't improved with other treatments will be randomly assigned to one …

This study tests whether a new model where physiotherapists lead primary care for hip and knee pain can improve patients' daily function and quality of life. About 728 adults with hip or knee pain will take part across multiple clinics. Researchers will measure pain, function, an…

This study looks at two different exercise programs—closed kinetic chain exercises and isometric exercises—to see which better reduces pain and improves daily function in women aged 35 to 60 with knee osteoarthritis and patellofemoral pain syndrome. 70 participants will do 12 ses…

This study tests whether a single injection combining the patient's own platelet-rich plasma with a gel-like substance can reduce pain and stiffness in people with moderate to severe knee osteoarthritis. About 280 participants will receive either the combination, a standard gel, …

This study tests a treatment called cryoneurolysis, which uses cold to temporarily freeze nerves around the knee before replacement surgery. The goal is to see if it reduces pain and the need for strong painkillers (opioids) after surgery. About 100 adults scheduled for knee repl…

This study tests a new gel containing ketoprofen, applied to the skin, for people with knee osteoarthritis. The goal is to see if it reduces pain and improves knee function. Forty adults with knee osteoarthritis are taking part in this single-blind trial.

This study tests whether using a blood pressure cuff during low-weight leg exercises (blood flow restriction) can reduce pain and improve strength and mobility in people with knee osteoarthritis. 75 adults aged 40-65 with moderate knee arthritis will do 16 supervised sessions ove…

This study tests whether combining blood flow restriction with anti-gravity treadmill walking is more effective than treadmill alone for knee osteoarthritis. About 70 adults aged 45-80 with confirmed knee OA will participate. The goal is to reduce pain, stiffness, and improve fun…

This study tests if a non-invasive technique called transcranial direct current stimulation (tDCS) can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with chronic knee pain will receive either real or fake tDCS over 15 sessions in three week…

This study looks at whether adding a special laser treatment (CO2 infrared laser moxibustion) to standard exercise can reduce pain and improve knee function in people with knee osteoarthritis. About 68 adults aged 55-65 with knee arthritis will receive either exercise alone or ex…

This study looks at two different methods to reduce pain after knee replacement surgery: using radiofrequency (heat) or a chemical called phenol to block the geniculate nerve. About 140 adults who had knee replacement for osteoarthritis will be randomly assigned to one of the two…

This study tests whether placing cabbage leaves on the knee can reduce pain and improve movement and quality of life in people with knee osteoarthritis. Ninety adults with knee pain for at least 6 months will be split into three groups: two groups get different cabbage leaf treat…

This study looks at two different non-surgical treatment plans for knee osteoarthritis in 300 military health system patients aged 18-60. All participants receive care based on official guidelines, and researchers track pain, stiffness, and physical function over one year. The go…

This study tests whether a special exercise program, guided by a patient navigator, can improve knee pain, stiffness, and function in people waiting for knee replacement surgery. About 84 adults with knee osteoarthritis will take part. The program focuses on exercises done before…

This study compares Basic Body Awareness Therapy (BBAT), a gentle mind-body movement approach, to conventional physiotherapy and home exercises for people with knee osteoarthritis. Researchers will measure pain, strength, balance, and quality of life in 63 adults aged 40-74 with …

This study looks at how well people with knee osteoarthritis can sense the position of their knee joint, with and without being able to see. Researchers measured the accuracy of knee positioning in 120 adults aged 40-80. The goal is to understand how vision affects joint awarenes…

This study involves 615 patients with severe hip or knee osteoarthritis who are eligible for joint replacement surgery. Researchers want to see if using a shared decision-making tool during doctor visits helps patients make more informed choices and feel more satisfied with their…

This study follows 124 golfers who had hip, knee, or shoulder replacement surgery to see how many return to golf and how long it takes. Researchers will also track changes in handicap, mobility, and joint pain over one year. The goal is to give patients and doctors clear informat…

This study helps patients and surgeons decide whether to replace both arthritic knees in a single surgery or to do them separately. It involves 224 participants with knee osteoarthritis who are considering bilateral knee replacement. The main goal is to compare health and recover…

This study looks at how common nerve-related pain is in people with knee osteoarthritis and whether it's linked to night pain. Researchers will ask 150 participants about their pain and sleep quality. The goal is to better understand these connections, not to test a new treatment…

This study looks back at 166 knee replacement patients who received a nerve block for surgery. Researchers want to see how much pain patients feel after the block wears off, and whether an educational intervention helps reduce that pain. The goal is to better understand and manag…

This study looks at whether using a wrist activity tracker, plus coaching and financial rewards, can help people become more physically active after total knee replacement surgery. About 600 adults aged 40-85 who are scheduled for knee replacement will be randomly assigned to usu…