KNEE OSTEOARTHRITIS

This study tests a combination of a patient's own stem cells and platelet-rich plasma to help heal broken bones that won't mend on their own and to treat knee arthritis. For people needing a knee replacement, doctors use custom 3D-printed guides made from the patient's scans to i…

This early-phase trial tests the safety of Allocetra-OTS, a cell therapy made from donor immune cells, injected into the knee joint of 18 people with end-stage osteoarthritis who are candidates for surgery. Researchers will monitor side effects and measure pain relief using a sta…

This study tests whether robot-assisted knee replacement surgery leads to better results than traditional manual surgery for people with knee osteoarthritis. About 95 participants will receive the robot-assisted procedure and use a special knee brace to track motion. Researchers …

This study tests whether stem cells taken from a person's own belly fat can help regenerate knee cartilage and reduce pain from osteoarthritis. Sixty adults with moderate to severe knee arthritis will receive either a stem cell injection or a standard hyaluronic acid shot. Resear…

This study looks at how stable a new type of knee replacement part (the tibial baseplate) is over time. It involves 31 people with knee osteoarthritis who are getting a total knee replacement. Researchers will use special X-rays to measure any movement of the implant between 6 mo…

This Phase 3 trial tests whether a single injection of ELIXCYTE, made from donor stem cells, can reduce knee pain better than a placebo (saline). About 165 adults aged 40-80 with moderate knee osteoarthritis who haven't gotten relief from standard treatments are participating. Th…

This early-stage trial tests whether injecting a patient's own stem cells into the knee can safely treat osteoarthritis and cartilage defects. Sixteen adults with knee pain will receive one injection of stem cells grown from their own bone marrow. Researchers will track side effe…

This study looks at how well a partial knee replacement device called MOTO Medial® works for people with knee osteoarthritis. About 269 adults will be followed for several years to see if their pain, knee function, and quality of life improve after surgery. The goal is to help pe…

This early-stage trial tests an experimental drug called RAB001, given as an injection into the knee joint, for people with knee osteoarthritis. The study includes 60 participants aged 40 to 75 who have persistent knee pain despite conservative treatments. Researchers are primari…

This study tests whether a supervised exercise program before hip or knee replacement surgery can improve recovery, function, and quality of life. 44 adults with advanced osteoarthritis will do 3 weekly physiotherapy sessions plus daily home exercises for several weeks before the…

This Phase 2 trial tests whether a paste made with ejiao (a traditional Chinese ingredient) can reduce knee pain in people with osteoarthritis. Sixty adults with knee pain will use either the ejiao paste, a similar paste without ejiao, or a synthetic control. The study aims to se…

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study tests whether injecting tiny beads into arteries around the knee can reduce pain in people with moderate to severe knee osteoarthritis. The beads block blood flow to the painful area. Nine adults aged 40 to 80 who have not gotten relief from standard treatments are tak…

This study compares two exercise programs—closed kinetic chain exercises and isometric exercises—to see which better reduces pain and improves function in women aged 35-60 with patellofemoral pain syndrome and knee osteoarthritis. Seventy participants will be randomly assigned to…

This study looks at whether starting to walk earlier after a type of knee surgery (open wedge high tibial osteotomy) helps reduce pain and improve function in people with knee osteoarthritis. About 72 participants will either start partial weight bearing at 2 weeks or wait until …

This study compares two types of blood flow restriction therapy (using a cuff to limit blood flow during exercise) against standard moderate strength training in 75 people with knee osteoarthritis. Participants will do supervised exercises twice a week for 8 weeks. The goal is to…

This study looks at whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the knee can reduce pain and improve movement in people with knee osteoarthritis. The trial involves 110 adults over 35 with knee arthritis. Researchers are…

This study was designed to see if an artificial intelligence app could help people with knee osteoarthritis do their exercises correctly at home. It planned to compare the app group to a group using a paper exercise booklet. The study was withdrawn before any participants were en…

This study looks at whether a 12-week group exercise program called Les Mills Thrive can change how muscles work and improve strength, balance, and symptoms in 42 older adults with knee osteoarthritis. Participants will attend weekly classes that include flexibility, strength, an…

This study tests a procedure called genicular artery embolization (GAE) for knee osteoarthritis pain. It involves injecting microscopic spheres into a knee artery to reduce blood flow and inflammation. About 100 people with moderate to severe knee pain will be randomly assigned t…

This study looks at whether adding mental imagery or watching exercise videos to standard physical therapy can help people who have had a knee replacement. About 36 adults will be split into three groups: standard therapy alone, standard therapy plus guided imagery, or standard t…

This study tests whether a powered knee exoskeleton called Keeogo can help veterans with knee osteoarthritis walk, climb stairs, and perform daily tasks with less pain compared to standard knee braces. Thirty-two veterans with moderate to severe knee osteoarthritis will try both …

This study tests whether taking probiotic supplements for 6 months can reduce pain, improve knee function, and boost quality of life in women aged 45-70 with knee osteoarthritis. Researchers will compare the probiotic group to a placebo group to see if the gut bacteria help lower…

This study tests a goal-setting program for adults with knee problems like arthritis or injuries. Participants work with their surgeon to create specific, measurable goals and track progress. The aim is to see if this approach helps patients achieve their treatment goals and impr…

This study looks at whether core stability exercises or ankle and foot strengthening exercises can help people with knee osteoarthritis feel better. About 100 adults aged 40 and older with moderate knee osteoarthritis will take part. The goal is to see which type of exercise redu…

This study looks at whether combining two types of exercises—Feldenkrais and active release—with standard physical therapy can help people with knee osteoarthritis feel less pain and move better. Forty adults aged 40 to 60 with mild to moderate knee OA will do these exercises thr…

This study tests whether adding blood flow restriction (a technique that gently limits blood flow to the legs) to walking on an anti-gravity treadmill can better reduce pain and improve function in people with knee osteoarthritis. About 70 adults aged 45-80 with knee arthritis wi…

This study tests whether adding a type of nerve stimulation (NESA or TENS) to a supervised exercise program can better reduce pain, improve function, and boost mental health in people over 60 with knee osteoarthritis. Over 8 weeks, 110 participants will receive either exercise pl…

This study tests whether adding a special laser treatment (CO2 infrared laser moxibustion) to standard exercise can reduce knee pain and improve movement in people with knee osteoarthritis. About 68 adults aged 55-65 with knee arthritis will receive either exercise alone or exerc…

This study tests whether a single injection of a mix of platelet-rich plasma (from your own blood) and hyaluronic acid can safely reduce pain and improve function in people with moderate to severe knee osteoarthritis. About 280 adults with grade 3-4 knee arthritis will receive ei…

This study compares a mind-body approach called Basic Body Awareness Therapy (BBAT) to standard physiotherapy and home exercise for people with knee osteoarthritis. BBAT focuses on gentle, mindful movements to improve posture, balance, and pain management. Researchers will measur…

This study planned to test whether a 6-day course of oral methylprednisolone after total knee replacement could improve pain, sleep, and knee movement. Participants would also receive a steroid injection during surgery. The study was withdrawn before enrolling anyone, so no concl…

This study tests whether applying cabbage leaves to the knee can reduce pain, improve physical function, and boost quality of life in people with knee osteoarthritis. Researchers will compare two different cabbage leaf preparations against standard care in 90 adults over four wee…

This study looks at two different methods to reduce pain in people who have had knee replacement surgery due to arthritis. One method uses radiofrequency (heat) to calm the nerve, and the other uses a chemical called phenol. The goal is to see which works better and is safer. Abo…

This study looks at two different non-surgical treatment plans for knee osteoarthritis in 300 military health system patients aged 18-60. The goal is to see which approach better improves physical function and reduces pain over one year. Participants will follow guidelines from t…

This study tests whether a home-based virtual reality system can help people with knee osteoarthritis do their physiotherapy exercises in a more engaging way. Fifty adults aged 45 and older with knee pain will be randomly assigned to either the VR program or standard physiotherap…

This early-stage study tests a new gel containing ketoprofen, applied to the skin, for people with knee osteoarthritis. The goal is to see if it reduces pain and improves knee function. Forty adults with knee osteoarthritis will be randomly assigned to receive the gel or a compar…

This study tests whether freezing specific nerves around the knee before total knee replacement surgery can reduce pain and the need for opioids afterward. One hundred adults scheduled for knee replacement will either receive the nerve-freezing treatment or a sham procedure. The …

This study tests whether a new physiotherapist-led primary care model can improve function and quality of life for adults with hip or knee pain. About 728 participants in Canada will be assigned to either the new model or usual care. The goal is to see if this approach reduces pa…

This study looks at two types of ultrasound-guided injections for people with knee osteoarthritis who haven't gotten relief from standard treatments like pills or physical therapy. One injection uses a chemical called phenol to block pain signals for a longer time, while the othe…

This study tests whether phone coaching and financial rewards can help people become more active after total knee replacement. 600 adults aged 40-85 will be split into three groups: usual care, activity tracker only, or activity tracker plus coaching and rewards. The goal is to s…

This study tests whether a guided exercise program done at home before knee replacement surgery can help people recover better. 84 adults scheduled for knee replacement will be asked to do simple exercises daily from the day they are admitted until surgery. Researchers will measu…

This study tests a new procedure called genicular artery embolization (GAE) against standard steroid injections for people with knee osteoarthritis. The goal is to see if blocking certain arteries with tiny beads can provide better pain relief than steroid shots. The trial involv…

This study tests whether a treatment called dorsal root ganglion stimulation (DRG-S) can reduce chronic knee pain caused by osteoarthritis. About 30 adults with long-term knee pain who have not had surgery or are not good candidates for it will receive a device that sends mild el…

This study tests whether a special type of platelet-rich plasma (PRP) injection, called biofiller PRP, can reduce pain, improve movement, and enhance quality of life in people with knee osteoarthritis. Sixty participants aged 45-65 with moderate knee arthritis will receive the in…

This study aimed to test different regional anesthesia techniques to help people recover faster and go home sooner after total knee replacement. It planned to compare a standard pain injection with an added nerve block or continuous nerve block infusion. However, the study was wi…

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This study reviewed records of 166 knee replacement patients who received a nerve block for pain. Researchers compared pain scores 6-24 hours after the block wore off between two groups: one that received extra education about pain management before surgery and one that did not. …

This study tests whether an AI chatbot can help people with hip or knee osteoarthritis feel less conflicted and anxious about their treatment choices. About 100 adults with osteoarthritis will chat with the AI before seeing their surgeon. Researchers will measure changes in decis…

This study looks at whether adding an extra nerve block to the usual pain block can reduce inflammation after total knee replacement. Researchers will measure inflammation markers in the blood of 60 adults. The goal is to see if this approach leads to less pain medicine use and b…

This study looks at whether using a patient decision aid during doctor visits helps people with severe hip or knee osteoarthritis make better choices about surgery. Researchers will track how informed patients feel, their involvement in decisions, and their pain, function, and qu…

This study compares having both knees replaced at the same time versus one after the other in people with knee osteoarthritis. About 224 participants will be randomly assigned to one approach. Researchers will track recovery, joint function, and quality of life to help guide pati…

This study looks at how hot bone gets during total knee replacement surgery when using a burr (robotic) versus a saw (conventional). Twenty patients will have their bone temperature measured with an infrared thermometer during the procedure. The goal is simply to compare the heat…

This study looks at how seeing or not seeing affects knee joint position sense in people with knee osteoarthritis. Researchers will measure how accurately 120 participants can position their knee with and without visual input. The goal is to better understand how the brain senses…

This study follows 124 golfers who have hip, knee, or shoulder replacement surgery. Researchers track how many return to golf, how long it takes, and how their game and joint function change over a year. The goal is to give patients and doctors clear, realistic expectations about…

This study looks at 150 people with knee osteoarthritis to see how often night pain and nerve pain (neuropathic pain) occur together. Researchers will use questionnaires and physical exams to measure pain and sleep quality. The goal is to better understand these pain types and th…