Could a single stem cell injection fix your knee arthritis?
NCT ID NCT03477942
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 41 times
Summary
This early-stage trial tests whether a single injection of a patient's own stem cells into the knee is safe and can help with osteoarthritis or cartilage injuries. Sixteen adults with knee pain will get the shot and be followed for two years. Researchers will check for side effects and measure pain, function, and cartilage quality on MRI.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MUSCULOSKELETAL PAIN are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
University Hospital Cleveland Medical Center
Cleveland, Ohio, 44106, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
stem cells (from the patient's own bone marrow)
What this could lead to
If it works, this could point toward a non-surgical treatment that repairs cartilage and treats the root cause of knee osteoarthritis, not just symptoms.
What could go wrong
This is a very early, small phase 1 trial with only 16 people. It primarily checks safety, not effectiveness. The stem cell procedure is complex and may not provide lasting benefit.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.