Can freezing nerves before knee replacement cut opioid use?
NCT ID NCT05840276
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether freezing specific nerves around the knee before total knee replacement surgery can reduce pain and the need for opioids afterward. One hundred adults scheduled for knee replacement will either receive the nerve-freezing treatment or a sham procedure. The main goal is to see if the freezing group uses less morphine in the first two weeks after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cryoneurolysis (nerve freezing using a device called VISUAL-ICE)
What this could lead to
If it works, this could offer a way to reduce pain and opioid use after knee replacement surgery, helping patients recover faster.
What could go wrong
This is a small, early-stage trial with only 100 participants. The sham control may not fully blind patients, and nerve freezing carries risks like temporary numbness or nerve damage.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital of Southwest Jutland
Esbjerg, Region Syddanmark, 6700, Denmark