KNEE OSTEOARTHRITIS

This study tests a stem cell product called XytriX, made from donated umbilical cord cells, for treating knee osteoarthritis. About 75 adults with mild to severe knee arthritis will receive an injection into the knee joint. The goal is to see if it safely reduces pain and improve…

This early-phase trial tests whether a single injection of Mytocel MSK (made from a patient's own ear cartilage) can improve knee osteoarthritis better than standard PRP injections. Thirty adults with mild-to-moderate knee arthritis will receive either the new cell therapy or PRP…

This study looks at a personalized plan to help older adults prevent falls. It includes 50 people aged 65 or older who have sarcopenia (muscle loss) and knee or hip arthritis. Researchers will test balance, strength, and range of motion to create a tailored fall prevention strate…

This trial compares three ways to manage pain after total knee replacement. All patients receive standard nerve blocks, but some also get an anti-inflammatory drug (dexamethasone) or a combination of dexamethasone and a sedative (dexmedetomidine). The goal is to see which approac…

This study tests whether adding shock wave therapy to a knee strengthening exercise program reduces pain and improves function more than exercise alone in people with knee osteoarthritis. Forty patients with moderate knee pain will be randomly assigned to either exercise only or …

This study compares two ways to manage knee osteoarthritis: doing your own exercise at a local fitness center versus supervised sessions with a physiotherapist. Researchers want to see if the cheaper, more flexible gym option is just as good at reducing pain and improving quality…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This pilot study tests whether a topical CBD oil can reduce pain in people with knee osteoarthritis. Thirty participants will apply either CBD in castor oil or plain castor oil to their knees twice daily for 30 days, then switch treatments. Researchers will track pain scores and …

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study tests a physical therapy program designed for older adults with knee osteoarthritis. The program focuses on mobility, balance, and fall prevention, and also considers each person's mental abilities. Forty participants aged 60 and older will take part in 16 sessions ove…

This study will test whether Egoscue postural exercises, alone or combined with a hands-on technique called Mobilization with Movement (MWM), can reduce pain, improve balance, and boost quality of life in people with knee osteoarthritis. Researchers plan to enroll 56 adults aged …

This study tests whether a gel called Conjuran can reduce pain in people with knee osteoarthritis better than the current standard treatment, Hyruan. About 180 adults with mild to moderate knee arthritis will receive two cycles of injections, each cycle consisting of five weekly …

This study tests whether a special exercise method called Sahrmann's approach can reduce pain and improve knee function better than standard physical therapy in people with knee osteoarthritis. Forty adults aged 40 to 60 with moderate knee arthritis will be assigned to one of two…

This study compares two pain relief methods after total knee replacement: a long-acting pain shot (Zynrelef) given directly into the knee during surgery versus a standard nerve block. The goal is to see which method better reduces the need for opioid painkillers in the first 72 h…

This study tests whether TECAR therapy—a device that delivers gentle heat deep into the knee—can reduce pain, improve balance, and boost quality of life in elderly men with knee osteoarthritis. Eighty men will receive either real TECAR plus standard physiotherapy or a sham versio…

This study tests whether a short, digitally guided exercise program before total knee replacement is practical and helpful. Sixty adults with knee osteoarthritis will either do the 10-14 day program or receive usual care. The main goal is to see if people stick with it and find i…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises at home, reducing pain and improving function as well as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receiving …

This study tests whether adding suzetrigine (Journavx) to standard pain management can lower pain and reduce the need for opioid painkillers after total knee replacement. About 75 adults with knee arthritis will take the drug as part of their post-surgery care. The goal is to imp…

This early study tests the safety of a single injection of a new polymer called ABR1 for knee osteoarthritis. About 25 adults with moderate to severe knee pain will receive the injection and be followed for 12 weeks. The main goal is to see if the treatment causes any side effect…

This study looks at whether using a gentle pulling force (mechanical traction) on the knee before or after exercise works better for easing pain and improving movement in people with knee osteoarthritis. Researchers will compare three groups: traction before exercise, traction af…

This study tests whether a special knee and heel brace, combined with strength exercises done while sitting or lying down, can reduce pain and improve walking in people with knee osteoarthritis. Twenty participants will be randomly assigned to get either this new brace or a stand…

This study looks at whether adding kinesiotaping (a special elastic tape) to standard physical therapy can improve pain, movement, and fear of activity in people with knee osteoarthritis. Sixty adults aged 40-65 with mild knee arthritis will be randomly assigned to receive either…

This study tests whether a special light treatment, called photobiomodulation, can reduce pain and swelling in people with long-term knee osteoarthritis. Researchers will measure pain levels before and after treatment in 30 adults aged 50 and older. The goal is to find a drug-fre…

This study tests two ways to numb the knee after total knee replacement. One method uses a low-dose anesthetic on three main nerves, while the other uses a higher dose on two smaller nerves. The goal is to see which provides better pain relief with less muscle weakness, so patien…

This study tests whether applying bee venom gel to the knee during ultrasound therapy can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40-75 will either get the bee venom treatment or a placebo gel. Researchers will measure pain, walking…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

This study compares two types of physical therapy for knee osteoarthritis: one done in a pool and one on land. Sixty-six adults aged 40-65 with knee osteoarthritis will receive either aquatic or land-based mobilization therapy for four weeks. Researchers will measure pain, stiffn…

This study looks at whether adding trunk (core) stabilization exercises to standard physical therapy can reduce knee pain and improve daily function in people with knee osteoarthritis who also have back pain (knee-spine syndrome). About 70 adults aged 40-60 with moderate knee art…

This study looks at whether a special two-bar knee brace, combined with strength exercises that don't put weight on the knee, can help people with knee osteoarthritis feel less pain and stiffness. 18 adults aged 45-60 with moderate knee arthritis will be split into two groups: on…

This study will look back at medical records of 133 adults aged 40-70 with painful knee osteoarthritis who received a single injection of hyaluronic acid. The goal is to see if one shot can reduce pain, stiffness, and improve function, potentially offering a simpler alternative t…

This study looks at whether walking to music or a metronome can help reduce pain and change how muscles work in people with chronic knee osteoarthritis. Twenty adults with knee pain will walk under different conditions—with music, with a metronome, or without either—while researc…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This study compares two minimally invasive procedures to relieve long-term knee pain from osteoarthritis. One uses radiofrequency (heat) to block pain nerves, the other uses a small amount of alcohol. About 50 adults aged 45-85 with moderate to severe knee pain will be randomly a…

This study tests a new injection called NANOVAE for people with knee osteoarthritis. The treatment is made from human amniotic fluid and is given directly into the knee joint. The goal is to see if it is safe and can help reduce pain and improve function. The study will include 2…

This study tests if a surgeon can numb the knee during replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see if the surgeon's technique provides equal pain relief and r…

This study tests whether tecar therapy, a type of targeted radiofrequency treatment, can reduce pain and improve physical function in people with chronic knee osteoarthritis. About 60 adults aged 40 to 75 with moderate knee arthritis will receive the therapy or a sham treatment. …

This study tests whether using a heart rate sensor to personalize home exercise can reduce pain and improve daily function better than a standard exercise program. About 240 adults aged 45+ with mild-to-moderate knee osteoarthritis will follow a 12-week program, with follow-up at…

This study tests whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. About 52 adults aged 40-60 with moderate knee arthritis will be randomly assigned to either the exercise pro…

This study tests whether a powder made from Rosa roxburghii (a type of rose fruit) can help people recover after total knee replacement surgery for osteoarthritis. 184 participants will take either the supplement or a placebo daily for 30 days after surgery. Researchers will meas…

This study tests whether applying metformin gel through the skin with a mild electric current (iontophoresis) plus physical therapy can reduce pain and improve function in postmenopausal women with knee osteoarthritis. Sixty-eight women aged 50-70 will receive either the active g…

This study compares two add-on treatments for knee osteoarthritis in overweight women: walking on an anti-gravity treadmill that unloads the joints, or taking alpha-lipoic acid and omega-3 supplements. Both aim to reduce pain and improve function better than standard physical the…

This study tests whether adding a procedure called fenestration (making small holes in the cyst wall) to standard aspiration and steroid injection can improve outcomes for people with painful Baker's cysts behind the knee. Forty-four adults with knee osteoarthritis and a Baker's …

This study looks at whether healthy lifestyle education and personalized physical activity advice can reduce pain and improve daily function in people with knee osteoarthritis. About 26 adults aged 40 and older with knee osteoarthritis will be placed into one of three groups: sup…

This study tests a nursing program based on the ABC-X model for 117 adults aged 30-65 getting their first total knee replacement. The program helps patients and families handle stress, find support, and think more positively. Researchers will measure mental strength, self-care, e…

This study will enroll 68 adults aged 45-70 with grade III knee osteoarthritis to compare two physical therapy techniques: Mulligan mobilization with eccentric exercises versus Kaltenborn sustained mobilization with eccentric exercises. Participants will attend 3 sessions per wee…

This study tests whether a gel containing etodolac, applied to the skin over the knee, can improve pain and function when added to standard physiotherapy. Thirty people with mild to moderate knee osteoarthritis will receive either physiotherapy alone or physiotherapy plus the gel…

This study compares two physical therapy approaches for people with knee osteoarthritis: a gentle 'positional release' technique targeting tight leg muscles, versus balance and coordination exercises. Researchers will measure changes in pain, stiffness, and daily function in 60 p…

This study compares two surgical techniques for total knee replacement: mechanical alignment (the traditional method) and kinematic alignment (a newer approach). Researchers want to see which method leads to less pain and better knee function after surgery. About 96 adults with k…

This study will compare three common injection treatments for knee osteoarthritis: steroids, dextrose prolotherapy, and platelet-rich plasma (PRP). Seventy-two adults aged 40 to 80 with moderate to severe knee arthritis will receive one of the three injections. Researchers will m…

This study looks at whether a common procedure for varicose veins—called endovenous ablation—can also reduce knee pain in people aged 80 and older. The researchers will follow 50 participants for one year after treatment, measuring pain and knee function. The goal is to see if im…

This study tests whether injecting tiny gold particles into the knee can reduce pain and the need for additional treatments in people with knee osteoarthritis. About 240 adults with long-term knee pain will receive either gold microparticles or a placebo. The goal is to see if th…

This study tests whether inulin, a prebiotic fiber from chicory root, can reduce inflammation and knee pain in older adults with osteoarthritis. Over 8 weeks, 84 participants will take either inulin or a placebo daily. Researchers will measure changes in blood markers of inflamma…

This study tests whether wrapping an elastic band around the knee (tissue flossing) combined with simple exercises can reduce pain and improve movement in people with knee osteoarthritis. Fifty-eight adults aged 40-70 with mild to moderate knee OA will be split into two groups: o…

This study tests whether virtual lifestyle-focused pain care works as well as in-person care for adults with chronic back, knee, or hip pain living in rural areas. Participants will receive up to 10 sessions over six months, either in-person with a physiotherapist or virtually wi…

This study tests whether adding a steroid to the standard pain injection during total knee replacement improves pain control and reduces the need for opioid painkillers. 240 adults undergoing knee replacement will be randomly assigned to receive either the standard injection, one…

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage…

This study looks at whether a routine blood test can predict which patients with knee osteoarthritis will get good pain relief from platelet-rich plasma (PRP) injections. Researchers will enroll 120 people aged 40-60 with moderate knee arthritis. Each person will receive three PR…

This study will test whether a short health aid—a tool that corrects common misunderstandings about knee osteoarthritis—can help patients feel less worried and make clearer treatment choices. About 159 adults with knee osteoarthritis will be randomly assigned to review the health…

This study investigates whether alexithymia—a condition where people struggle to identify and describe their emotions—affects how well patients with knee osteoarthritis respond to physical therapy. Sixty participants aged 40 to 75 with moderate knee osteoarthritis will receive a …

This study will compare two FDA-approved machines that make platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from a person's own blood and is injected into the knee to help with pain and stiffness. The researchers will check if the two machines produce …

This study will compare women with knee osteoarthritis who also have lipedema (a fat tissue disorder) to those without lipedema. Researchers will use ultrasound to measure knee cartilage thickness and questionnaires to assess pain and daily function. The goal is to understand if …

This study will check how many people with knee osteoarthritis also have sarcopenia—a condition of low muscle mass and strength. Researchers in Upper Egypt will study 224 adults aged 40 and older to measure muscle health, nutrition, and quality of life. The goal is to better unde…

This study looks back at medical records of 3,500 adults who had a first-time knee replacement to compare different brands of knee implants. Researchers want to see which implant leads to better knee function, fewer complications, and lower costs over time. The goal is to help do…

This observational study will measure two substances in the blood—COMP and MMP-3—in 60 people with knee osteoarthritis and healthy controls. Researchers want to see if these markers relate to pain, function, and X-ray findings. No treatment is given; the goal is to better underst…

This study will use special PET/MRI scans to look at changes in knee metabolism after a procedure called genicular artery embolization (GAE) for knee osteoarthritis. The goal is to understand why some people get good pain relief and others do not. About 25 adults with moderate to…

This study will follow 50 adults with varicose veins and chronic knee pain who are scheduled for standard vein treatment (laser or radiofrequency ablation). Researchers will measure changes in knee pain, stiffness, and function before and after the procedure. The goal is to see i…