KNEE OSTEOARTHRITIS

This study is testing a paste called Knee Pain Ejiao Paste to see if it can reduce pain in people with knee osteoarthritis. About 60 adults with knee pain will use the paste for 12 weeks. The goal is to find out if this traditional remedy works better than a paste without the act…

This study tests whether applying bee venom gel to the skin with ultrasound (phonophoresis) can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40 to 75 with moderate to severe knee pain will be randomly assigned to receive either the bee v…

This study compares an AI-assisted exercise app to a standard paper exercise program for people with knee osteoarthritis. About 84 adults with knee pain will use either the smart app or a paper handout for 6 weeks. The goal is to see if the AI tool can better reduce pain and impr…

This study looks at whether adding an iPACK nerve block to a standard adductor canal block can lower the body's inflammatory response and improve pain control after hip replacement surgery. It involves 60 older adults (ages 65-100) who are scheduled for hip replacement under spin…

This study looks at whether adding trunk (core) stabilization exercises to usual physical therapy can reduce knee pain and improve daily function in people with knee osteoarthritis who also have back pain. About 70 adults aged 40-60 with mild to moderate knee arthritis and a hist…

This study looks at two different ways to help overweight women with knee osteoarthritis feel better and move easier. One method uses a special treadmill that takes weight off the knees, while the other uses dietary supplements (alpha lipoic acid and omega-3 fatty acids). The goa…

This study looks at whether a procedure to fix varicose veins can also reduce knee pain in people aged 80 and older. Researchers will treat 50 participants with endovenous ablation and track their pain and knee function for a year. The goal is to see if improving blood flow in th…

This study looks at whether healthy lifestyle education and a custom physical activity plan can reduce pain and improve daily function in people with knee osteoarthritis. About 26 adults aged 40 and older with knee osteoarthritis will be split into three groups: supervised exerci…

This study compares two methods of aligning a new knee joint during total knee replacement surgery. One method aims for a neutral, straight alignment, while the other tries to match the patient's natural knee angle. The goal is to see which approach leads to less pain and better …

This study looks at whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. About 52 adults aged 40-60 with moderate knee arthritis will be split into two groups: one doing the stre…

This study looks at whether walking to music or a metronome can reduce pain and change how muscles work in people with chronic knee osteoarthritis. About 20 adults with knee pain will try three walking conditions: with music, with a metronome, and without either. Researchers will…

This study tests whether a special two-bar knee brace combined with strength training exercises (that don't require standing) can better reduce pain and stiffness in people with knee osteoarthritis compared to a standard brace with the same exercises. The trial will involve 18 ad…

This study tests whether inulin, a natural dietary fiber, can reduce inflammation and knee pain in older adults with osteoarthritis. Over 8 weeks, 84 participants will take either inulin or a placebo. Researchers will measure changes in blood markers of inflammation and self-repo…

This study compares adding two different steroids to the standard pain injection given during total knee replacement surgery. The goal is to see which option reduces pain, lowers the need for opioid painkillers, and improves knee movement and recovery. About 240 adults with sever…

This study tests whether a special gel containing etodolac, applied to the skin, can improve pain and movement when added to standard physical therapy for knee osteoarthritis. Thirty adults aged 45-60 with mild to moderate knee arthritis will be split into two groups: one gets ph…

This study tests if a surgeon can numb the knee during surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see which approach provides better pain relief and recovery.

This study compares robotic-assisted knee replacement surgery to the standard manual procedure for people with knee osteoarthritis. About 346 adults will be randomly assigned to one of the two surgeries and followed for a year to see which provides better pain relief, function, a…

This study looks at whether using AI-assisted videos to explain knee replacement surgery can lower patients' anxiety and fear of moving after the operation. About 150 adults aged 55 and older scheduled for knee replacement will either get standard education or watch AI-generated …

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises as effectively as in-person physiotherapy. 264 adults aged 50 and older with knee pain will be split into three groups: in-person sessions, AI-guided home exercises, or a mix of…

This study tests whether tiny gold particles injected into the knee can reduce pain and the need for additional treatments in people with knee osteoarthritis. About 240 adults with long-term knee pain will receive either gold microparticles or a placebo. The goal is to see if thi…

This study looks at whether doing your own exercise at a local fitness center works as well as supervised sessions with a physiotherapist for knee osteoarthritis. About 300 adults aged 45 and older with knee pain will be assigned to either self-managed gym workouts or standard ph…

This early-stage trial tests a new injection called NANOVAE for people with knee osteoarthritis. The study will include 24 adults aged 21 to 75 with moderate knee arthritis. The main goal is to check if the injection is safe and if it helps reduce pain and improve balance.

This study looks at a common knee problem called Baker's cyst, which causes pain and swelling behind the knee. Researchers want to see if making tiny openings in the cyst wall (fenestration) during a standard fluid-draining procedure helps symptoms improve more and keeps the cyst…

This study tests a personalized home exercise program for people with knee osteoarthritis. Using a heart rate sensor and app, exercises are adjusted daily based on your body's recovery state. The goal is to see if this tailored approach reduces pain and improves daily function be…

This study compares two types of physical therapy—one done in water and one on land—to see which better reduces pain and improves daily function in people with knee osteoarthritis. About 66 adults aged 40 to 65 with knee arthritis will be assigned to one of the two groups. Both g…

This study will compare two hands-on physical therapy techniques—Mulligan's Mobilization with Movement and Kaltenborn's Sustained Mobilization—combined with eccentric exercises to reduce pain and improve daily function in people with knee osteoarthritis. Sixty-eight adults aged 4…

This study will follow 99 adults aged 50 to 80 who are having knee replacement surgery. It aims to see if giving the steroid dexamethasone (by mouth or IV) around the time of surgery helps reduce pain, improve mobility, and lessen nausea compared to not giving it. The drug is giv…

This study compares two methods to control pain after total knee replacement: a new long-acting painkiller (Zynrelef) injected into the knee during surgery versus a standard nerve block. Researchers will measure how much opioid pain medication patients need in the first 72 hours …

This study compares two physical therapy approaches for people with knee osteoarthritis: a positional release technique targeting specific leg muscles versus exercises to improve balance and joint awareness. The goal is to see which method better reduces pain, stiffness, and disa…

This study compares three types of knee injections—steroids, dextrose prolotherapy, and platelet-rich plasma (PRP)—to see which works best for reducing pain and improving function in people with knee osteoarthritis. Researchers will enroll 72 adults aged 40 to 80 who have had per…

This study will use advanced PET/MRI scans to look at changes in knee metabolism after a procedure called genicular artery embolization (GAE) for knee osteoarthritis. The goal is to understand why some patients get significant pain relief while others do not. Researchers will enr…

This study looks at how lipedema, a condition where fat builds up in the legs, affects knee osteoarthritis in women aged 30-65. Researchers will compare two groups of women with knee arthritis—those with and without lipedema—using ultrasound to measure cartilage thickness and que…

This study looks back at medical records of 3,500 adults who had a first-time knee replacement to compare different implant brands. The goal is to see which implants lead to better knee function, fewer complications, and lower costs over the medium to long term. Results will help…

This study looks at whether two substances in the blood, called COMP and MMP-3, are linked to how severe knee osteoarthritis is. Researchers will measure these levels in 60 people with and without knee arthritis and compare them to pain, function, and X-ray findings. The goal is …

This study looks at 50 adults with varicose veins and knee pain to see if standard vein treatment also eases knee discomfort. Participants get their usual vein care, and researchers track changes in knee pain and function over time. The goal is to understand the link between vein…