Knee implant materials put to the test in human cells

NCT ID NCT07671521

Not yet recruiting Knowledge-focused Sponsor: Stefano Zaffagnini Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage, inflammation, and other signs of toxicity to ensure the materials are safe before moving to animal or human trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: titanium alloy and polylactic acid (PLA) materials, with platelet-rich plasma (PRP)
What this could lead to: If successful, this study could confirm that these materials are safe and help improve how well knee grafts heal, leading to better surgical outcomes.
What could go wrong: This is a very early lab study using cells in a dish, not in people. Results may not predict what happens inside the body, and further testing is needed.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYTOTOXICITY

Contacts and locations

Locations

IRCCS Rizzoli Orthopedic Institute

Bologna, Bologna, 40136, Italy

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