Could a chicory root fiber soothe your aching knees?

NCT ID NCT07189585

Not yet recruiting Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study tests whether inulin, a prebiotic fiber from chicory root, can reduce inflammation and knee pain in older adults with osteoarthritis. Over 8 weeks, 84 participants will take either inulin or a placebo daily. Researchers will measure changes in blood markers of inflammation and self-reported knee pain to see if this simple dietary supplement offers relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: inulin (a prebiotic fiber from chicory root)
What this could lead to: If it works, this could point toward a simple dietary supplement to ease knee pain and inflammation in older adults with osteoarthritis.
What could go wrong: This is a small, early-phase trial with only 84 participants. The benefit may be small or no different from placebo, and inulin can cause digestive discomfort.

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Conditions

The condition(s) this trial relates to.

Inflammation osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

VA Connecticut Healthcare System, West Haven Campus

West Haven, Connecticut, 06516, United States

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