New knee pain block could get you walking faster after surgery

NCT ID NCT07578688

Not yet recruiting Symptom relief Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests two ways to numb the knee after total knee replacement. One method uses a low-dose anesthetic on three main nerves, while the other uses a higher dose on two smaller nerves. The goal is to see which provides better pain relief with less muscle weakness, so patients can start walking sooner and use less morphine. The trial will involve 120 adults scheduled for knee replacement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: naropeine (a local anesthetic)
What this could lead to: If successful, this could point to a better way to manage pain after knee replacement, reducing the need for strong painkillers and helping patients walk sooner.
What could go wrong: This is a small, early-stage trial with only 120 participants. The results may not apply to all patients, and the low-dose block might not provide enough pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE SURGERY

Contacts and locations

Locations

Clinique Jouvenet

Paris, 75016, France

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