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Breathing against resistance may ease knee arthritis pain

NCT ID NCT07698418

Symptom relief Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study tests whether a simple breathing exercise—inhaling against resistance using a handheld device—can reduce knee pain in people aged 55 and older with knee osteoarthritis. Participants will do the exercises at home for 8 weeks, with gradually increasing resistance. The trial will measure pain, physical function, inflammation markers, and nervous system activity. If it works, this drug-free approach could offer a safe, low-cost option for managing chronic knee pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
inspiratory muscle training (breathing exercises against resistance)
What this could lead to
If effective, this simple, non-drug breathing exercise could offer a safe, low-cost way to manage knee pain and reduce reliance on painkillers or surgery.
What could go wrong
This is a small, early-stage trial with 80 participants. The sham group may also show improvement, and the benefits may not last beyond the training period.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 55 years or older. * Knee osteoarthritis (Kellgren-Lawrence grade ≥ 2). * Knee pain (Visual Analogue Scale, VAS ≥ 3) on the most days in the past month. * Able to walk independently without assitive devices. Exclusion Criteria: * History of knee replacement surgery, meniscus surgery, or ligament surgery. * Received corticosteroid injection within the previous three weeks. * Diagnosed with rheumatoid arthritis. * Unstable angina, recent myocardial infarction, uncontrolled cardiac arrhythmia, or severe heart failure. * History of stroke. * Currently receiving steroid therapy, hormonal therapy, or cancer chemotherapy. * Pneumothorax, pulmonary bullae, lung surgery within the past 12 months, unstable asthma, or severe dyspnea at rest. * Unable to understand the study procedures and potential risks.

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Conditions

The condition(s) this trial relates to.

Chronic Pain osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis Knee osteoarthritis (knee oa)

How to take part

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  1. The official record

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