Could a steroid injection after knee surgery cut opioid use?
NCT ID NCT07151417
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether adding a steroid to the standard pain injection during total knee replacement improves pain control and reduces the need for opioid painkillers. 240 adults undergoing knee replacement will be randomly assigned to receive either the standard injection, one with a traditional steroid, or one with a newer extended-release steroid. Researchers will track pain, opioid use, knee movement, and recovery for up to a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- methylprednisolone and triamcinolone acetonide extended-release (Zilretta)
- What this could lead to
- If successful, this could point to a better way to manage pain after knee replacement, reducing opioid use and improving recovery.
- What could go wrong
- This is an early-to-mid-stage trial with 240 participants, so results may not apply to everyone. Steroids can affect blood sugar, especially in people with diabetes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Walter Reed National Military Medical Center
Bethesda, Maryland, 20889, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact
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