Can a brain monitor guide safer anesthesia during knee replacement?

NCT ID NCT07736352

Not yet recruiting Knowledge-focused Sponsor: China-Japan Friendship Hospital Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether adding midazolam, dexmedetomidine, or esketamine to standard propofol anesthesia helps maintain the right depth of unconsciousness during knee replacement. One hundred adults scheduled for surgery will have their brain waves and vital signs monitored as the anesthesia dose is gradually lowered. The goal is to identify the ideal brain-monitor readings and drug levels that keep patients safely asleep without over-sedation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: propofol, remifentanil, midazolam, dexmedetomidine, esketamine
What this could lead to: If successful, this could help anesthesiologists tailor drug combinations for safer, more precise anesthesia during knee replacement surgery.
What could go wrong: This is a small, early-phase trial focused on monitoring rather than outcomes, so results may not change practice directly. Individual responses to anesthesia vary widely.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASA CLASS I/II PATIENTS ELECTIVE SURGICAL PATIENTS KNEE OSTEOARTHRITIS REPLACEMENT, KNEE

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