KNEE OSTEOARTHRITIS

This study tests whether injecting stem cells from umbilical cord tissue can reduce pain and improve knee function in people with knee osteoarthritis. About 100 adults aged 40-70 will receive either the stem cells or a placebo. The goal is to see if this treatment can control the…

This early-stage study tests a new gene therapy called BBM-A101 for people with moderate knee osteoarthritis. The goal is to see if it is safe and can help reduce pain or improve joint function. About 81 adults with knee arthritis will receive the treatment and be monitored for s…

This study is testing a new knee replacement system called Persona Revision in 380 adults who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. Participants will be followed for 2 years after surgery.

This study tests if a special treadmill training program before total knee replacement surgery can help prevent falls after the operation. Participants will be split into two groups: one gets fall-prevention information only, the other also does two weeks of treadmill perturbatio…

This study tests whether a pre-surgery exercise program (prehabilitation) helps people waiting for hip or knee replacement. Researchers want to see if it improves recovery time, physical function, and mental well-being. The study will include 44 adults with advanced osteoarthriti…

This study tests whether a new, more concentrated growth factor injection (SRF) works better than standard PRP for knee osteoarthritis. About 90 adults aged 20-80 with mild to moderate knee arthritis will receive one of the two injections. The goal is to see if SRF provides great…

This study looks at whether doing physical therapy exercises through a video game helps people with knee osteoarthritis more than standard exercises. Sixty adults with knee OA will do 10 weeks of quad-strengthening exercises, some using a special game with sensors and others foll…

This study looks at whether adding low-level laser therapy to a home exercise program can reduce pain and improve knee function in people over 50 with knee osteoarthritis. It also checks if the laser helps thicken thigh muscle and knee cartilage. About 62 participants will be ran…

This study looks at whether a structured physical therapy program can improve how people walk and distribute weight on their feet after total knee replacement surgery. Researchers will measure walking speed, step length, and foot pressure in 30 women aged 40-70 before and after t…

This study tests whether adding foot massage to standard cold therapy can reduce pain, improve satisfaction, and lower painkiller use in people who have had knee replacement surgery. Sixty adults will be randomly assigned to receive either cold therapy alone or cold therapy plus …

This study compares two types of nerve blocks to control pain after total knee replacement. 80 adults aged 65 and older will receive one of two combinations of numbing injections. The goal is to see which method provides longer pain relief and helps people get moving sooner after…

This study looks at what personal and clinic visit factors help predict how well people with knee osteoarthritis respond to a topical pain gel called diclofenac. About 220 adults aged 50 and older with confirmed knee arthritis will use the gel for 8 weeks, complete questionnaires…

This study looks at whether a hands-on technique called Mobilization with Movement (MWM) can help reduce pain and inflammation in people with knee osteoarthritis. Forty adults with moderate to severe knee OA will receive either MWM or a fake version, plus standard care, twice a w…

This study looks at whether an 8-week yoga program can improve daily function and reduce pain in people with knee osteoarthritis. Researchers will compare yoga to standard therapeutic exercises in 90 adults aged 45 and older. The goal is to see if yoga offers a practical, effecti…

This study tests whether a special calf muscle massage (myofascial release) can reduce pain and improve walking and daily function in women with knee osteoarthritis. Thirty women aged 45-55 with mild to moderate knee arthritis will receive either the real massage or a sham treatm…

This study tests if using MRI scans to guide sugar-water injections into specific damaged areas of the knee works better than standard injections into the joint space for treating knee osteoarthritis. Researchers will enroll 60 adults aged 45-80 with moderate knee arthritis. The …

This study tests a single injection made from donated human placental tissue (PTP-001) to see if it improves pain and function in people with knee osteoarthritis. About 260 adults aged 40 to 80 with mild to moderate knee OA will receive either the injection or a placebo and be fo…

This study tests a new knee injection called ALLOHEAL for people with knee osteoarthritis. The gel-like filler aims to reduce friction and pain in the joint. About 286 adults aged 40 to 79 will receive either ALLOHEAL or a standard treatment to see if it works just as well for ea…

This study tests whether remimazolam, a newer anesthetic, causes less confusion (delirium) after hip or knee surgery in older adults compared to the standard drug propofol. About 82 elderly patients will receive one of the two drugs during surgery. Researchers will check for conf…

This study compares two types of knee replacement implants designed to better match each patient's natural knee shape and movement. The goal is to see which implant helps patients feel more like their knee is their own, with less stiffness or discomfort. About 120 adults needing …

This study looks at whether a 3-week thermal spa treatment in Enghien-les-Bains can reduce pain and improve daily function for people with knee osteoarthritis. About 76 adults aged 50-80 with moderate to severe knee arthritis will receive the spa therapy and continue their usual …

This study tests whether adding shock wave therapy to knee exercises reduces pain and improves function better than exercises alone in people with knee osteoarthritis. About 40 adults with moderate knee pain will participate during a hospital stay, receiving either exercises plus…

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee joint can reduce pain and improve movement in people with knee osteoarthritis. About 31 adults aged 45 to 75 with knee arthritis will receive the injection and be followed for changes in pain…

This study looks at two types of injections for knee osteoarthritis pain: one with dextrose (a type of sugar) and one with a standard numbing medicine. About 86 adults with knee pain for at least 3 months will receive these injections as part of their routine care. Researchers wi…

This study tests whether a 10-week telehealth program combining exercise and mindfulness can reduce pain and improve function in people with knee osteoarthritis. About 66 adults aged 50 and older with persistent knee pain will participate entirely from home. The goal is to see if…

This study compares two treatments for knee osteoarthritis: an ultrasound-guided genicular nerve block and standard physical therapy. Researchers will measure pain, mobility, and balance in 66 adults aged 40-70 with knee pain for at least 3 months. The goal is to find which appro…

This study tests a non-drug approach for people with knee osteoarthritis and low back pain. Participants will have a cuff on one thigh that briefly stops blood flow for 5 minutes at a time, repeated over 2 weeks. The goal is to see if this improves walking speed, muscle strength,…

This study looks at whether taking collagen peptide supplements before and after total knee replacement surgery can improve tissue healing, strength, and recovery. About 44 adults aged 50–75 with knee osteoarthritis will take either collagen or a placebo. Researchers will measure…

This study looks at whether adding dexamethasone or dexmedetomidine to a standard numbing medicine can improve pain control and reduce the need for strong painkillers after total knee replacement. About 96 older adults having knee surgery will be randomly assigned to one of three…

This study tests which imaging method—fluoroscopy or ultrasound—works better for a procedure called cooled radiofrequency ablation to treat knee osteoarthritis pain. The procedure uses heat to calm the nerves causing pain. Researchers will compare pain and function in 90 adults w…

This study tests whether a special magnetic therapy (HI-PEMF) can reduce pain and improve strength in older adults with knee osteoarthritis. About 64 people aged 60 and older will receive either joint-only or joint-plus-muscle treatment, plus a home exercise program. The goal is …

This study tests a brain stimulation technique called rTMS to see if it can reduce knee arthritis pain and depression in older adults. Thirty volunteers aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS along with Tai Chi. The goal is to…

This study looks at two methods for knee replacement surgery: one that puts the new joint in a neutral position (mechanical alignment) and one that matches your knee's natural alignment (kinematic alignment). About 95 people getting a knee replacement will be randomly assigned to…

This study tests whether giving duloxetine, an antidepressant that also eases pain, before and after knee replacement surgery can lower the need for opioid painkillers. About 150 adults with knee osteoarthritis will take duloxetine or a placebo around the time of their surgery. T…

This study compares two different nerve block methods (iPACK and BiFeS) for pain relief after total knee replacement surgery. 74 adults having knee replacement will receive one of the two blocks along with a standard adductor canal block. The goal is to see which approach leads t…

This study tests a procedure called genicular artery embolization (GAE) for people with knee osteoarthritis. The goal is to see if blocking certain blood vessels in the knee can reduce pain and inflammation. About 46 adults with persistent knee pain will get MRIs, questionnaires,…

This study looks at the best way to start group physical therapy programs for veterans with knee osteoarthritis at 20 VA facilities. About 20 sites will take part, and patients with knee pain from arthritis may join. The goal is to make it easier for more veterans to get this hel…

This study looks at two different ways to align a new knee joint during robotic-assisted knee replacement surgery. About 240 people with knee osteoarthritis will be randomly assigned to one of two alignment methods. The goal is to see which approach helps patients feel more natur…

This study tests whether a magnesium supplement called Magnesium-L-Threonate can improve sleep quality and reduce pain in 64 adults after total knee or hip replacement surgery. Participants will take the supplement or a placebo and report changes in sleepiness and sleep quality. …

This study compares two knee braces to see which one better reduces pain and improves walking in people with knee osteoarthritis. About 30 adults aged 40-85 with mild to moderate knee arthritis will wear a brace for 8 weeks. Researchers will measure pain levels and how the knee m…

This study tests whether platelet-rich plasma (PRP) injections work better than hyaluronic acid (HA) injections for people with advanced knee osteoarthritis (grades III-IV). About 150 adults with knee pain will receive either PRP or HA injections and be followed for up to 12 mont…

This study tests whether a single injection of hydrolyzed collagen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 204 adults who have not gotten relief from other treatments will receive either the collagen injection or a placebo (sal…

This study tests whether combining the Bowen technique (a gentle hands-on therapy) with backward walking can improve hamstring flexibility, reduce pain, and boost mobility in people with knee osteoarthritis. About 36 adults aged 40-60 with mild to moderate knee OA will participat…

This study tests whether doing supervised exercise and learning about your condition before knee replacement surgery leads to better knee function and satisfaction one year later, compared to standard care. About 110 adults with knee osteoarthritis will take part. The goal is to …

This study looks at two different ways to give a nerve block (adductor canal block) for pain after total knee replacement surgery. The goal is to see which method provides better pain control and helps patients get up and move sooner. About 78 adults having knee replacement will …

This study tests whether custom-made, 3D-printed knee replacements fit better and cause less pain than standard ones. About 20 people with knee osteoarthritis will get either a custom or standard implant. The goal is to see if the custom approach improves alignment, reduces pain,…

This study tests if injecting a sugar (dextrose) solution around knee nerves can reduce chronic pain from knee osteoarthritis better than a numbing medicine alone. About 60 adults with knee arthritis will receive a series of three injections. Researchers will measure pain levels …

This study tests whether a single injection of cells from bone marrow or from fat tissue can better reduce pain and improve knee function in people with knee osteoarthritis. Researchers will enroll 204 adults aged 40 to 75 who have not gotten relief from standard treatments. The …

This study tests whether CartiPRO, an approved collagen injection, can safely reduce knee pain in people with osteoarthritis or cartilage damage. About 194 adults will receive two injections 24 weeks apart. Researchers will measure pain, knee function, and quality of life over 36…

This study tests whether adding a sleep improvement program to personalized exercise coaching helps older adults with knee osteoarthritis feel less pain. About 288 participants with knee pain and insomnia will receive either exercise coaching alone or exercise plus sleep treatmen…

This study tests whether focused shockwave therapy can safely reduce knee pain and improve function in people with osteoarthritis who also have bone marrow lesions. Fifteen adults with persistent knee pain will receive four weekly shockwave sessions or standard care (pain relieve…

This study tests a single injection called 4P004 for people with knee osteoarthritis and joint swelling (synovitis). About 129 adults aged 40-80 will receive either the study drug or a placebo. The main goal is to see if the injection reduces daily knee pain and improves function…

This study looks at whether a mobile app can help people do simple exercises while still in bed after hip, knee, or spine surgery. About 100 adults will use the app to guide their recovery, and researchers will measure how well they regain movement and how satisfied they are with…

This study compares two types of anesthesia (general vs. spinal) for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications in about 2,400 participants. The goal is to find out which method leads to b…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery to see when and how they return to golf. Participants are active golfers who want to play again after surgery. Researchers will check in at 6 weeks, 3 months, 6 months, and 1 year after surgery to …

This study tests whether hyaluronic acid injections into the knee can reduce inflammation and pain in people with knee osteoarthritis. Researchers will measure inflammatory markers in blood and joint fluid, and track pain and function over time. 50 adults aged 45-75 with moderate…

This study looks at 180 people with knee osteoarthritis to see if brain scans, knee MRIs, and pain tests can predict who will get the most relief from duloxetine, celecoxib, or a placebo. Participants take one of these treatments for about 20 weeks and report their pain levels. T…

This study looks at how the angle of your knee bones, seen on an X-ray, relates to pain, fear of moving, and quality of life in people with knee osteoarthritis. Researchers will measure pain, function, and fear of movement in 100 adults using questionnaires and compare these to t…

This study aims to improve total knee replacement surgery for people with bow-legged (varus) knees due to osteoarthritis. Researchers will use CT scans to compare the affected and healthy legs in 300 adults, helping surgeons decide how much to straighten the knee during surgery. …

This study looks at how the shape and movement of the kneecap relate to knee pain in people with patellofemoral pain (runner's knee) or knee osteoarthritis. Researchers will use special CT scans taken while standing to measure the knee's structure. The goal is to find links that …

This study is a large registry that will follow 10,000 people with knee osteoarthritis to see how different pain treatments work in everyday life. Treatments include nerve blocks, injections, and surgery. The goal is to collect data on pain, function, and side effects to help doc…

This study looks at how well different knee realignment surgeries (osteotomies) work over the long term for people with knee arthritis and a crooked leg. Researchers will follow 150 patients aged 18 to 70 to measure knee function and symptoms. The goal is to see if these procedur…

This study looks at whether special insoles that measure how you walk, along with other health information, can predict how much your knee will improve after replacement surgery. About 200 adults with knee osteoarthritis scheduled for surgery will participate. The goal is to help…

This study aims to create and validate an Italian version of the New Knee Society Knee Scoring System, a questionnaire that measures knee function and symptoms. About 300 Italian patients with knee osteoarthritis who are scheduled for knee replacement surgery will test the transl…

This pilot study tests a new instrument to help surgeons balance the knee's main ligament (MCL) during total knee replacement. The goal is to see if the tool makes the procedure more consistent and repeatable. About 40 adults with knee osteoarthritis who need a knee replacement w…

This study aims to see if artificial intelligence (AI) can use patient information—like genetics, behavior, and physical tests—to predict recovery after total knee replacement. Researchers will follow 197 adults with severe knee osteoarthritis for one year after surgery. The goal…

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) for early knee arthritis to see how the kneecap joint changes over the long term. Researchers will measure kneecap height and arthritis progression using X-rays and patient questionnaires. The g…

This study looks at how a person's neighborhood resources affect their recovery after knee replacement surgery. Researchers will use a remote monitoring device to track physical progress and compare it to standard care. The goal is to see if remote monitoring can reduce the numbe…

This study is testing a smartphone app that tracks movement and symptoms in people with knee or hip arthritis or joint replacement. The goal is to create a score that predicts who will be satisfied after surgery. About 1,250 adults in Germany will participate, using the app to sh…

This study aims to find biological markers in blood and joint fluid that can predict how knee osteoarthritis will progress and whether treatments like steroid injections will work. Researchers will follow 200 people with knee osteoarthritis and 100 with other inflammatory joint c…

This study uses special wearable sensors to measure how people with severe knee osteoarthritis move before and after total knee replacement surgery. Researchers want to better understand movement problems and find simple ways to track improvement. The study involves 20 adults ove…