Could a placenta injection ease your knee pain?
NCT ID NCT07219771
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether a single injection of particles from donated placental tissue (PTP-001) can reduce pain and improve function in people with knee osteoarthritis. About 260 adults aged 40–80 with mild-to-moderate knee OA will receive either the placental injection or a placebo (saline). The study lasts 52 weeks and measures changes in pain and daily activities.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
placental tissue particles (PTP-001, also called MOTYS)
What this could lead to
If it works, this could provide a new, non-surgical option to reduce pain and improve knee function for people with mild-to-moderate knee osteoarthritis.
What could go wrong
This is still an experimental treatment, and it's being compared to a placebo (saline injection). Even if effective, it may only help some people and not cure the underlying arthritis.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Central Research Associates, LLC dba Flourish Research
RECRUITINGBirmingham, Alabama, 35205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chicago Clinical Research Institute, Inc.
RECRUITINGChicago, Illinois, 60607, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Coastal Carolina Research Center, LLD
RECRUITINGNorth Charleston, South Carolina, 29405, United States
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Conquest Research, LLC
RECRUITINGWinter Park, Florida, 32789, United States
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Emeritus Research Sydney
RECRUITINGBotany, New South Wales, 2019, Australia
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Focus Clinical Research
RECRUITINGWest Hills, California, 91307, United States
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Genesis Research Services
RECRUITINGBroadmeadow, New South Wales, 2292, Australia
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Horizon Clinical Research
RECRUITINGLa Mesa, California, 91942, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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JBR Clinical Research, LLC
RECRUITINGSalt Lake City, Utah, 84107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Lehigh Center for Clinical Research
RECRUITINGAllentown, Pennsylvania, 18104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Momentum Clinical Research Sunshine
RECRUITINGSt Albans, Victoria, 3021, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Momentum Clinical Research Taringa
RECRUITINGTaringa, Queensland, 4068, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Momentum Clinical Research Wellers Hill
TERMINATEDTarragindi, Queensland, 4121, Australia
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Royal North Shore Hospital
RECRUITINGSt Leonards, New South Wales, 2065, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of the Sunshine Coast Clinical Trials, Birtinya
RECRUITINGBirtinya, Queensland, 4575, Australia
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University of the Sunshine Coast Clinical Trials, Morayfield
RECRUITINGMorayfield, Queensland, 4506, Australia
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University of the Sunshine Coast Clinical Trials, Noosa
RECRUITINGNoosaville, Queensland, 4566, Australia
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