Could a placenta injection ease your knee pain?

NCT ID NCT07219771

Recruiting now Symptom relief Sponsor: Doron Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether a single injection of particles from donated placental tissue (PTP-001) can reduce pain and improve function in people with knee osteoarthritis. About 260 adults aged 40–80 with mild-to-moderate knee OA will receive either the placental injection or a placebo (saline). The study lasts 52 weeks and measures changes in pain and daily activities.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: placental tissue particles (PTP-001, also called MOTYS)
What this could lead to: If it works, this could provide a new, non-surgical option to reduce pain and improve knee function for people with mild-to-moderate knee osteoarthritis.
What could go wrong: This is still an experimental treatment, and it's being compared to a placebo (saline injection). Even if effective, it may only help some people and not cure the underlying arthritis.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

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Locations

Central Research Associates, LLC dba Flourish Research
RECRUITING

Birmingham, Alabama, 35205, United States
Chicago Clinical Research Institute, Inc.
RECRUITING

Chicago, Illinois, 60607, United States
Coastal Carolina Research Center, LLD
RECRUITING

North Charleston, South Carolina, 29405, United States

Contact Email: •••••@•••••
Conquest Research, LLC
RECRUITING

Winter Park, Florida, 32789, United States
Emeritus Research Sydney
RECRUITING

Botany, New South Wales, 2019, Australia
Focus Clinical Research
RECRUITING

West Hills, California, 91307, United States
Genesis Research Services
RECRUITING

Broadmeadow, New South Wales, 2292, Australia
Horizon Clinical Research
RECRUITING

La Mesa, California, 91942, United States
JBR Clinical Research, LLC
RECRUITING

Salt Lake City, Utah, 84107, United States
Lehigh Center for Clinical Research
RECRUITING

Allentown, Pennsylvania, 18104, United States
Momentum Clinical Research Sunshine
RECRUITING

St Albans, Victoria, 3021, Australia
Momentum Clinical Research Taringa
RECRUITING

Taringa, Queensland, 4068, Australia
Momentum Clinical Research Wellers Hill
TERMINATED

Tarragindi, Queensland, 4121, Australia
Royal North Shore Hospital
RECRUITING

St Leonards, New South Wales, 2065, Australia
University of the Sunshine Coast Clinical Trials, Birtinya
RECRUITING

Birtinya, Queensland, 4575, Australia
University of the Sunshine Coast Clinical Trials, Morayfield
RECRUITING

Morayfield, Queensland, 4506, Australia
University of the Sunshine Coast Clinical Trials, Noosa
RECRUITING

Noosaville, Queensland, 4566, Australia

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