Knee replacement showdown: which alignment works best?

NCT ID NCT04246138

Recruiting now Disease control Sponsor: Hull University Teaching Hospitals NHS Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two methods of aligning a new knee joint during total knee replacement surgery: kinematic alignment and mechanical alignment. Researchers want to see which method gives better function and movement one year after surgery. The trial will involve 100 adults with knee osteoarthritis who are getting a knee replacement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: knee replacement surgery with either kinematic or mechanical alignment
What this could lead to: If it works, this could show that one alignment method leads to better knee function and range of motion after replacement.
What could go wrong: This is a small, early-stage study with only 100 participants, so results may not apply to everyone. The difference between methods might be small or not meaningful.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KINEMATICAL ALIGNMENT,MECHANICAL ALIGNMENT, NAVIGATION

Contacts and locations

Locations

Hull University teaching hospitals
RECRUITING

Hull, East Yorkshire, HU3 2JZ, United Kingdom

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