New surgical wash aims to cut joint infection risk in 7,600 replacement patients

NCT ID NCT05543941

Recruiting now Disease control Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new surgical irrigation solution called XPERIENCE can lower the risk of joint infection after hip or knee replacement better than the standard dilute Betadine wash. About 7,600 adults having primary hip or knee replacement will be randomly assigned to receive one of the two washes before the wound is closed. The main goal is to see how many develop an infection within 90 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: XPERIENCE Advanced Surgical Irrigation (a device/solution applied to the wound during surgery)
What this could lead to: If it works, this could provide a better way to prevent serious joint infections after hip or knee replacement surgery.
What could go wrong: This is a large trial, but it compares two existing approaches, so the difference may be small. The solution is new, so unexpected side effects or no benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis osteoarthritis, hip osteoarthritis, knee osteonecrosis periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIP ARTHRITIS HIP OSTEOARTHRITIS KNEE ARTHRITIS KNEE OSTEOARTHRITIS

Contacts and locations

Locations

CHU de Quebec-Université Laval
RECRUITING

Québec, Quebec, Canada
Humber River Health
RECRUITING

Toronto, Ontario, Canada
Hôpital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, Canada
Jewish General Hospital
RECRUITING

Montreal, Quebec, Canada
London Health Sciences Center
RECRUITING

London, Ontario, Canada
St. Joseph's Health Centre
RECRUITING

Toronto, Ontario, Canada
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
University of British Columbia
RECRUITING

Vancouver, British Columbia, Canada

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