Stem cell gel could offer new hope for knee arthritis sufferers

NCT ID NCT07339111

Recruiting now Disease control Sponsor: Medipost, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with moderate knee osteoarthritis will be randomly assigned to receive either the stem cell gel plus debridement or debridement alone. The study will track pain and function for two years, and also use MRI to see if the treatment can slow arthritis progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CARTISTEM (human umbilical cord blood stem cells mixed with hyaluronic acid gel)
What this could lead to: If successful, this could provide a new treatment option that reduces knee pain and improves function, potentially slowing osteoarthritis progression without major surgery.
What could go wrong: This is a single Phase 3 trial with 300 participants. The stem cell gel may not prove superior to simple debridement, and long-term safety or effectiveness is not yet established.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE CARTILAGE DEFECTS

Contacts and locations

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Locations

AZ Orthopedic
RECRUITING

Tempe, Arizona, 85224, United States
Atrium Health Mercy
NOT_YET_RECRUITING

Charlotte, North Carolina, 28207, United States
Curalta Clinical Trials
RECRUITING

Westwood, New Jersey, 07662, United States
Flourish Research Birmingham
RECRUITING

Birmingham, Alabama, 35205, United States
Flourish Research San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Futuro Clinical Trials
RECRUITING

McAllen, Texas, 78501, United States
HD Research Corp.
RECRUITING

Houston, Texas, 77401, United States
Horizon Clinical Research
NOT_YET_RECRUITING

La Mesa, California, 91924, United States

Contact Email: •••••@•••••
JBR Clinical Research
RECRUITING

Salt Lake City, Utah, 84107, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Hermann Center
RECRUITING

Houston, Texas, 77043, United States
New York Presbyterian Queens
RECRUITING

Flushing, New York, 11355, United States
Orthopedic Centers of Colorado
RECRUITING

Parker, Colorado, 80134, United States

Contact Email: •••••@•••••
Source Healthcare
RECRUITING

Santa Monica, California, 90403, United States
Steamboat Orthopaedic and Spine Institute
RECRUITING

Steamboat Springs, Colorado, 80487, United States
The Ohio State University Jameson Crane Sports Medicine Institute
RECRUITING

Columbus, Ohio, 43202, United States
TriWest Research Associates
RECRUITING

El Cajon, California, 91910, United States
UK Orthopaedic Surgery & Sports Medicine - Turfland
RECRUITING

Lexington, Kentucky, 40504, United States
University of Cincinnati Department of Orthopaedic Surgery
RECRUITING

Cincinnati, Ohio, 45267, United States
West Clinical Research
RECRUITING

Morehead City, North Carolina, 28557, United States

Contact Email: •••••@•••••
Zenos Clinical Research
RECRUITING

Dallas, Texas, 75230, United States

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