Stem cell gel could offer new hope for knee arthritis sufferers
NCT ID NCT07339111
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with moderate knee osteoarthritis will be randomly assigned to receive either the stem cell gel plus debridement or debridement alone. The study will track pain and function for two years, and also use MRI to see if the treatment can slow arthritis progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CARTISTEM (human umbilical cord blood stem cells mixed with hyaluronic acid gel)
What this could lead to
If successful, this could provide a new treatment option that reduces knee pain and improves function, potentially slowing osteoarthritis progression without major surgery.
What could go wrong
This is a single Phase 3 trial with 300 participants. The stem cell gel may not prove superior to simple debridement, and long-term safety or effectiveness is not yet established.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
Locations
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AZ Orthopedic
RECRUITINGTempe, Arizona, 85224, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Atrium Health Mercy
NOT_YET_RECRUITINGCharlotte, North Carolina, 28207, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Curalta Clinical Trials
RECRUITINGWestwood, New Jersey, 07662, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Flourish Research Birmingham
RECRUITINGBirmingham, Alabama, 35205, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Flourish Research San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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HD Research Corp.
RECRUITINGHouston, Texas, 77401, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Horizon Clinical Research
NOT_YET_RECRUITINGLa Mesa, California, 91924, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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JBR Clinical Research
RECRUITINGSalt Lake City, Utah, 84107, United States
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Mayo Clinic Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memorial Hermann Center
RECRUITINGHouston, Texas, 77043, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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New York Presbyterian Queens
RECRUITINGFlushing, New York, 11355, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Orthopedic Centers of Colorado
RECRUITINGParker, Colorado, 80134, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Source Healthcare
RECRUITINGSanta Monica, California, 90403, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Steamboat Orthopaedic and Spine Institute
RECRUITINGSteamboat Springs, Colorado, 80487, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Ohio State University Jameson Crane Sports Medicine Institute
RECRUITINGColumbus, Ohio, 43202, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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TriWest Research Associates
NOT_YET_RECRUITINGEl Cajon, California, 91910, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Cincinnati Department of Orthopaedic Surgery
RECRUITINGCincinnati, Ohio, 45267, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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West Clinical Research
RECRUITINGMorehead City, North Carolina, 28557, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zenos Clinical Research
RECRUITINGDallas, Texas, 75230, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••