Knee pain relief without surgery? PRP injections tested against standard care

NCT ID NCT07016672

Recruiting now Symptom relief Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study tests whether injections of platelet-rich plasma (PRP) work better than hyaluronic acid (HA) for people with advanced knee osteoarthritis (grades III or IV). 150 participants will receive three injections of either PRP or HA and be followed for a year. The goal is to see which treatment reduces pain and improves knee function more.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Platelet-rich plasma (PRP) and hyaluronic acid (HA)
What this could lead to: If PRP works better than HA, it could offer a longer-lasting, non-surgical option for people with advanced knee osteoarthritis who cannot have surgery.
What could go wrong: This is a small, early-stage study with no blinding, so results may be biased. PRP is not yet proven for advanced osteoarthritis, and benefits may be modest or temporary.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

Centre Hospitalier Intercommunal de Toulon- La Seyne sur Mer - Hôpital Sainte Musse
RECRUITING

Toulon, Var, 83100, France

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