One-Shot collagen jab could soothe aching knees
NCT ID NCT04998188
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single injection of collagen into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare the collagen injection to a placebo (saline) injection in 204 adults. The main goal is to see if collagen provides better pain relief over 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- collagen injection
- What this could lead to
- If it works, this could provide a simple, one-time injection to reduce knee pain from osteoarthritis.
- What could go wrong
- This is an early-stage trial comparing collagen to a placebo (saline). The effect may be small or no better than placebo, and results are limited to 6 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Istituto Ortopedico Rizzoli
RECRUITINGBologna, 40136, Italy
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