Istituto Ortopedico Rizzoli

This study compares two surgical techniques for knee replacement surgery. Researchers want to see if using a special tensioning device during surgery leads to better knee stability and less pain after the operation compared to the standard technique. The study will involve 200 pa…

This study compares two different cell injection treatments for knee osteoarthritis. Researchers want to see whether cells taken from a patient's bone marrow or cells taken from their fat tissue work better at reducing pain and possibly slowing the arthritis. About 200 people wit…

This study is testing a new surgical method to repair severe rotator cuff tears in the shoulder. Doctors will use a special patch made from human skin tissue combined with cells taken from the patient's own bone marrow and shoulder bursa. The goal is to see if this combination he…

This study is testing whether a combined surgical approach works better than standard surgery alone for certain knee problems. It involves patients aged 20-60 with knee arthritis, poor leg alignment, and a missing meniscus (a knee cushion). Half will get a surgery to realign the …

This study is testing a procedure called arterial embolization to treat painful, growing desmoid tumors. Doctors inject tiny particles to block the tumor's blood supply, aiming to shrink it and relieve pain, but without using chemotherapy. The study will enroll about 20 patients …

This study is testing a three-layer scaffold implant to repair knee cartilage damaged by osteochondritis dissecans (OCD). Researchers will follow 30 patients aged 15-40 for up to 5 years after surgery to see how well the implant works. They will use questionnaires, physical exams…

This study is looking at a surgical technique to repair loose pieces of bone and cartilage in the knee using special screws that dissolve over time. It aims to see how well this method works for young patients (ages 12-35) to relieve pain, restore function, and most importantly, …

This study is testing a specific surgical technique to repair a serious type of knee cartilage tear called a 'root tear.' The goal is to see if this surgery can help the meniscus heal properly and prevent the development of painful knee arthritis later on. Researchers will follow…

This study is testing a personalized, 3D-printed hip socket implant for people who need a second surgery because their first hip replacement failed. The implant is custom-made from a CT scan to fit the patient's specific bone damage. Researchers will follow 15 patients for three …

This study is testing whether a custom-made ankle replacement works better than a standard one for people with severe ankle arthritis. Researchers will compare how well the ankle is aligned after surgery, how much pain patients have, and how well they can move. They will also loo…

This study aims to understand the long-term results of surgery for severe knee injuries where multiple ligaments are torn. Researchers will look back at 140 patients who had surgery between 2000 and 2019 to see how well their knees function years later, focusing on stability and …

This study compares two surgical methods for total knee replacement: the standard technique versus a newer computer-assisted navigation method. Researchers will measure which approach leads to better pain relief, knee function, recovery time, and cost-effectiveness. The study wil…

This study is testing whether electrochemotherapy can shrink painful desmoid tumors and improve patients' quality of life. It's for people whose tumors are growing and who can't have surgery or other standard treatments. Researchers will use MRI scans and questionnaires to track …

This study is comparing different types of knee realignment surgery (osteotomy) to see which works best long-term for treating arthritis in patients whose legs are bowed or knock-kneed. It aims to control the disease and delay or avoid the need for a full knee replacement. Resear…

This study is testing whether using small motion sensors to guide the surgeon during a total knee replacement leads to better results for patients. It will involve 40 people aged 50-85 who need a knee replacement due to severe arthritis. Researchers will track how well patients r…

This study aims to find the best combination of blood and joint fluid tests to diagnose infections in artificial hips and knees more quickly and accurately. It will involve 270 people who need surgery to fix or replace their artificial joint. The goal is to help doctors choose th…

This study aims to find better ways to prevent painful foot ulcers in people with type 2 diabetes. Researchers will compare two groups: those at risk of developing ulcers and those who have had ulcers before. They will use medical exams, blood tests, and foot scans over one year …

This study is testing whether a single injection of a collagen solution into the knee joint works better than a placebo (saltwater) injection to ease pain and improve function in people with knee osteoarthritis. It will involve 204 participants whose symptoms haven't improved wit…

This study is testing whether injections of platelet-rich plasma (PRP) from a patient's own blood can relieve pain and improve function in people with chronic tennis elbow. Researchers will compare two different PRP preparations against a placebo saline injection in 240 adults wh…

This study is testing whether injections made from a patient's own blood can help reduce pain and stiffness from hip osteoarthritis. Researchers are comparing two different preparations of platelet-rich plasma (PRP) to see which works better. About 230 participants will receive t…

This study is testing whether adding video-based physical therapy (telerehabilitation) to standard in-person sessions helps people recover better after hip replacement surgery. Researchers will compare pain levels, mobility, and patient satisfaction between two groups: one receiv…

This study is testing whether using virtual reality (VR) headsets can help children feel less anxious and experience less pain during minor orthopedic surgeries. It will compare children using calming VR environments to children receiving the standard sedative medication before t…

This study aims to see which of two common knee injections works better for reducing pain from arthritis behind the kneecap. Researchers will compare a single injection of platelet-rich plasma (PRP, made from a patient's own blood) against a single injection of hyaluronic acid (H…

This study is testing if adding a lubricating gel (hyaluronic acid) to an injection of a person's own processed fat tissue works better for knee arthritis pain than the fat tissue injection alone. Each of the 100 participants will have one knee treated with the fat+gel combo and …

This study is testing whether physical therapy done through video calls (telerehabilitation) works as well as traditional in-person therapy for people recovering from rotator cuff shoulder surgery. Researchers will compare pain levels, shoulder movement, and overall function in 4…

This study is evaluating a new type of prosthetic leg that attaches directly to the thigh bone, bypassing the traditional, often painful socket. Researchers will assess how this 'osteointegrated' implant affects mobility, pain, and quality of life in 15 adults with above-knee amp…

This study is testing which type of knee injection works best for osteoarthritis pain and stiffness. Researchers are comparing platelet-rich plasma (PRP), hyaluronic acid gel, and a combination of both in 288 adults with knee arthritis. Participants receive one injection and are …

This study follows 50 patients for over 5 years after knee realignment surgery to understand how the procedure affects the kneecap joint over time. Researchers are observing patients who previously had surgery to correct knee deformity and early arthritis, tracking changes throug…

This study aims to improve surgery for children and young adults with severe bone deformities by using advanced 3D computer planning and custom-printed surgical guides. Researchers will track 100 patients to see if these tools help surgeons achieve more accurate corrections, redu…

This study is developing a new way to deliver chemotherapy drugs to bone and soft tissue tumors using tiny nanoparticles and light. Researchers will test this approach on tumor samples from patients to see if it works better than standard chemotherapy. The goal is to gather stron…

This study aims to understand how brittle bone disease (Osteogenesis Imperfecta) affects the heart over time. Researchers will observe 40 children and adults with the condition for five years, using standard heart tests and questionnaires. The goal is to gather evidence to help d…

This study is collecting information about children under 18 who have leg bone deformities, either from birth or acquired later. Researchers will follow 1000 children to understand how different treatments affect their mobility, pain, and overall quality of life. The goal is to g…

This study aims to see if physical therapists score a patient recovery scale the same way. Researchers will check if different therapists give the same score to the same patient (inter-observer reliability) and if the same therapist gives consistent scores over time (intra-observ…

This study is testing a new way to explain complex spine and prostate surgeries to patients before they agree to the procedure. Researchers will use videos and interactive tools to see if patients understand their options better compared to standard explanations. The goal is to h…

This study is creating a detailed registry to collect health information from people with Li-Fraumeni syndrome, a rare condition that increases cancer risk. By gathering data on genetics, medical history, treatments, and quality of life from up to 200 participants, researchers ai…

This study aims to understand the patterns of pain and recovery in the weeks after a limb amputation. Researchers will look back at the medical records of 150 patients to see how quickly they regained function and managed pain. The goal is to identify which factors, like age or t…

This study aims to understand what happens to a special dissolving foot implant over many years. Researchers will look back at medical records and perform MRI scans on about 35 children who had this foot surgery at least 5 years ago. The main goal is to see how well the implant b…

This study aims to understand how bone density changes around two different designs of knee implants. Researchers will follow 50 patients who need total knee replacement for severe arthritis, measuring their bone strength and knee function over two years. The goal is to gather in…

This study looks back at cases since 1980 and follows new patients to understand why high-grade bone cancer sometimes returns locally after treatment. Researchers will track 150 patients who experienced cancer recurrence to identify what factors influence survival after the cance…

This study aims to understand how well patients follow a personalized home exercise program after major leg surgery for bone cancer. Researchers will track 50 patients for six months to see how consistently they do their exercises and what factors might influence their commitment…

This study aims to understand why knee replacements sometimes loosen without infection, a major reason they fail and need costly redo surgery. Researchers will look at patient records and X-rays from a regional registry to identify patterns and calculate the financial impact on t…

This study is creating and testing an Italian version of a standard knee questionnaire. Researchers will translate the questionnaire and then give it to 300 Italian patients with knee arthritis who are scheduled for knee replacement surgery. The goal is to provide Italian doctors…

This study aims to find out which factors in a person's bone health, muscle strength, and nutrition might predict who is more likely to have complications after spine surgery. Researchers will collect detailed health information from 200 adults scheduled for spine surgery for wea…

This study aims to understand why older adults with knee arthritis are at higher risk of falling. Researchers will measure muscle strength, power, and movement control in 50 participants over two years to see which factors best predict a fall. The goal is to gather knowledge to h…