Istituto Ortopedico Rizzoli

This study tests a new surgical technique for people with ankle bone and cartilage damage. Doctors will place a special scaffold enriched with the patient's own bone marrow cells under the damaged area to help it heal. The goal is to improve pain and function in 20 participants.

This study is for people with symptomatic desmoid tumors that are growing and cannot be treated with surgery or cryoablation. The treatment involves delivering a chemotherapy drug (doxorubicin) directly into the tumor's blood vessels to shrink it and reduce pain. Researchers will…

This study tests whether a special patch made from donated human skin, combined with cells from the patient's own bone marrow and shoulder lining, can improve surgical repair of large rotator cuff tears. About 72 adults with massive tears will receive the patch during surgery. Th…

This study is testing a new silver-coated hip replacement device to see if it can lower the chance of infection after surgery. The study will include 70 adults who are at high risk for infection, such as those with diabetes or weak immune systems. Researchers will track infection…

This study looks at how well a metal implant that attaches directly to the thigh bone works for people who have lost a leg above the knee. The implant replaces the traditional socket, which often causes skin problems and pain. Researchers will track 15 adults to see if the implan…

This study looks at a new way to fix a specific type of knee tear called a meniscal root tear. The surgery stitches the torn part of the meniscus to a nearby ligament to help the knee work better and prevent future arthritis. About 59 people who have had this surgery will be foll…

This study is testing custom-made, 3D-printed hip implants for 15 adults who have severe bone loss after failed hip replacement or infection. The implants are designed from CT scans to fit each person's unique bone damage. Researchers will track complications, pain, mobility, and…

This study compares knee realignment surgery alone versus realignment plus a donor meniscus transplant in 52 adults aged 20-60 with knee osteoarthritis and a missing meniscus. The goal is to see if the combined approach provides better pain relief, function, and joint protection.…

This study is testing a custom-made, 3D-printed ankle and talar implant for people with severe bone loss or damage in the ankle. The implant is designed to fit each patient perfectly, which may help preserve ankle function and reduce surgical impact. The study will follow 26 part…

This study looks at whether electrochemotherapy (ECT) can shrink desmoid fibromatosis tumors and improve symptoms. About 30 people with growing, painful tumors who cannot have surgery or other treatments will receive ECT. Researchers will track tumor size with MRI and quality of …

This study looks at a treatment for desmoid tumors, which are rare but painful growths. Instead of using chemotherapy, doctors will block the blood supply to the tumor using tiny particles. The goal is to reduce pain, shrink the tumor, and improve quality of life. About 20 people…

This study is testing a special three-layer scaffold to help repair damaged knee cartilage in people with osteochondritis dissecans, a condition where cartilage and bone separate. Researchers will enroll 30 patients aged 15 to 40 who have not improved with non-surgical treatments…

This study tests whether ankle replacements custom-designed from a patient's own CT scans work better than standard implants. About 24 adults with ankle arthritis will receive either a personalized or standard prosthesis. Researchers will measure bone alignment, patient satisfact…

This study looks at whether combining blood and joint fluid tests can more accurately detect infections in people who need a second hip or knee replacement surgery. Researchers will compare these tests to standard methods in 270 patients. The goal is to find the best, most cost-e…

This study aims to see if two simple physical exams can accurately diagnose chronic plantar fasciitis, a common cause of foot pain. Researchers will test 45 adults—some with the condition and some without—to measure how well these exams work. The goal is to make diagnosis quicker…

This study tests different strategies to prevent foot ulcers in people with type-2 diabetes. It includes 150 adults who are either at mild-to-moderate risk of developing a foot ulcer or have had one that healed at least 6 months ago. Researchers will track blood markers of inflam…

This study compares two ways to do total knee replacement: the standard method and one using computer navigation. Researchers want to see which gives better knee function, less pain, and lower costs. About 160 adults with knee arthritis will take part.

This study tests two kinds of platelet-rich plasma (PRP) injections for hip osteoarthritis. 230 adults with mild to moderate hip arthritis will receive either PRP with or without white blood cells. The goal is to see which type better reduces pain and improves function over 12 mo…

This study looks at 134 adults with De Quervain's disease, a painful hand condition. All participants get a steroid injection guided by ultrasound. Then, one group does standard hand therapy, while the other does eccentric exercises. The goal is to see which approach better reduc…

This study tests whether using virtual reality (VR) headsets can reduce anxiety and pain in children aged 7 to 12 during minor orthopedic surgery. Half the children will use calming VR environments before and during surgery, while the other half will receive standard sedative med…

This study tests a new treatment for people with painful knee arthritis in both knees. Each participant gets an injection of their own fat tissue in one knee and the same fat plus hyaluronic acid in the other. The goal is to see if the combination reduces pain and improves moveme…

This study looks at whether using motion sensors during knee replacement surgery helps improve how well the new knee works and how patients feel afterward. About 40 adults aged 50 to 85 who need a knee replacement will take part. Researchers will measure pain, movement, and quali…

This study looks at whether adding telerehabilitation (remote physiotherapy via video calls) to standard in-person therapy helps people recover better after total hip replacement. Researchers will compare pain, function, and satisfaction between those who get only in-person rehab…

This study tests whether injecting platelet-rich plasma (PRP) into the elbow can reduce pain and improve function in people with tennis elbow that hasn't gotten better with other treatments. 240 adults will receive either PRP with white blood cells, PRP without white blood cells,…

This study tests a procedure called transarterial microembolization (TAME) to reduce chronic knee pain in people with osteoarthritis. 43 adults with moderate knee arthritis and ongoing pain despite at least 3 months of standard treatments will be enrolled. The procedure blocks sm…

This study tests whether using virtual reality for 20 minutes before a minimally invasive radiology procedure can lower anxiety. About 236 adults will either use VR or receive standard care. Researchers will measure anxiety levels with questionnaires before and after the procedur…

This study looks at a procedure called arterial embolization to treat bone metastases (cancer that has spread to the bones). The goal is to reduce pain and improve quality of life with a minimally invasive approach. Researchers will follow 60 participants to measure pain levels a…

This study tests whether a single injection of hydrolyzed collagen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 204 adults who have not gotten relief from other treatments will receive either the collagen injection or a placebo (sal…

This study compares online physical therapy (telerehabilitation) with in-person sessions for people recovering from arthroscopic rotator cuff repair. About 46 adults aged 40-70 will take part. The goal is to see if virtual visits can provide similar relief for pain and improve sh…

This study tests whether custom-made, 3D-printed knee replacements fit better and cause less pain than standard ones. About 20 people with knee osteoarthritis will get either a custom or standard implant. The goal is to see if the custom approach improves alignment, reduces pain,…

This study tests whether a single injection of cells from bone marrow or from fat tissue can better reduce pain and improve knee function in people with knee osteoarthritis. Researchers will enroll 204 adults aged 40 to 75 who have not gotten relief from standard treatments. The …

This study tests a keyhole surgery to correct bunions (hallux valgus) in 40 adults. The goal is to reduce pain and improve foot movement. Participants must have a moderate bunion angle and no other foot problems needing surgery.

This study compares two injection treatments—fresh PRP (platelet-rich plasma) and hyaluronic acid—for people with patellofemoral osteoarthritis (knee arthritis). The goal is to see which one better reduces pain and improves knee function over 12 months. The trial is recruiting 16…

This study aims to see if a combination injection of platelet-rich plasma (PRP) and hyaluronic acid works better than either injection alone for knee osteoarthritis. It will involve 288 adults with knee pain who haven't gotten enough relief from standard treatments. Participants …

This study looks at how loose the knee is during surgery for ACL reconstruction, ACL revision, or meniscus transplant. Researchers will use a computer navigation system and a special device to measure knee movement right in the operating room. The goal is to gather information, n…

This study looks at how bone density around a new knee joint changes over two years, comparing two common implant designs. Fifty people getting a cemented total knee replacement will have bone scans and complete surveys about their knee function. The goal is to see which implant …

This study looks at whether a special MRI analysis called radiomics can predict if a desmoid tumor will grow back after cryoablation (freezing treatment). Desmoid tumors are non-cancerous but can be painful and aggressive. The study will compare radiomics to standard size-based c…

This study looks at heart structure and function in people with osteogenesis imperfecta (OI), a condition that makes bones fragile. Researchers want to learn how often heart problems occur in people with OI and how they change over time. The goal is to help doctors screen for hea…

This study looks at how well dissolvable screws work to fix loose cartilage pieces in the knee. It includes 100 people aged 12 to 35 who had or will have this surgery. The goal is to see if this method helps prevent long-term knee problems like pain and arthritis.

This study is testing a new way to deliver chemotherapy directly to sarcoma tumors using tiny particles activated by light through a fiber optic cable. Researchers will work with cells and tissue samples from 30 patients aged 0 to 85 who are having surgery or a biopsy. The goal i…

This study aims to find out if markers of bone and muscle health can predict complications after spinal surgery. Researchers will collect data from 200 adults undergoing spine surgery, including imaging, tissue samples, and questionnaires about pain and quality of life. The goal …

This study follows 150 people with high-grade osteosarcoma whose cancer returned near the original site. Researchers will look at medical records to find factors that affect survival after this relapse. The goal is to learn more, not to test a new treatment.

This study looks at how muscle strength, power, and control relate to fall risk in older adults with knee osteoarthritis. Researchers will measure these factors in 50 participants aged 65-80 using tests like dynamometers, stair climbing, and home monitoring. The goal is to find b…

This study looks at how well people with bone cancer follow a personalized exercise program at home after having surgery to remove a tumor from their leg. About 50 patients aged 12 and older will track their daily exercises for six months. The goal is to understand what helps or …

This study tests a new method using videos and online tools to help patients better understand their upcoming spine or urology surgery. Researchers want to see if this approach improves patient satisfaction and knowledge compared to standard consent forms. About 300 adults schedu…

This study looks back at medical records of 300 people with multiple osteochondroma, a rare genetic condition causing benign bone tumors. Researchers want to count and describe the surgeries these patients had, and see how surgery needs differ between children and adults. The goa…

This study looks at how pain and the ability to walk change in the days after a limb amputation. Researchers will review medical records of 150 adults who had an amputation. The goal is to find patterns that could help improve pain management and rehabilitation in the future.

This study looks at how well different knee realignment surgeries (osteotomies) work over the long term for people with knee arthritis and a crooked leg. Researchers will follow 150 patients aged 18 to 70 to measure knee function and symptoms. The goal is to see if these procedur…

This study aims to create and validate an Italian version of the New Knee Society Knee Scoring System, a questionnaire that measures knee function and symptoms. About 300 Italian patients with knee osteoarthritis who are scheduled for knee replacement surgery will test the transl…

This study looks at whether using a special tensioner device during knee replacement surgery helps balance the ligaments better than the usual method. About 200 people getting a specific type of knee implant will take part. Researchers will use stress X-rays and pain scores to co…

This study looks at children with birth defects or acquired problems in their lower leg bones. The goal is to collect information from 1,000 children to improve how doctors evaluate and treat these conditions. Researchers hope to use computer tools and artificial intelligence to …

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) for early knee arthritis to see how the kneecap joint changes over the long term. Researchers will measure kneecap height and arthritis progression using X-rays and patient questionnaires. The g…

This study looks at how bone growths (osteochondromas) affect movement and body shape in children and adults. Researchers will use wearable sensors, pressure mats, and 3D body scans to measure walking, balance, and joint motion. The goal is to find simple ways to track the diseas…

This study looks at a tool called the Iowa Level of Assistance (ILoA) scale, which measures how well patients recover after joint replacement surgery. Researchers want to see if different physiotherapists get the same results when using the scale, and if the same therapist gets c…

This study follows about 20 people who had surgery for flatfoot as children to see if the correction lasts over 10 years. Researchers will measure foot angles on X-rays and check for pain using a simple scale. The goal is to understand how well the surgery works in the long run.

This study is creating a detailed database of people with Li-Fraumeni syndrome, a rare condition that greatly increases cancer risk. Researchers will collect medical history, genetic data, and treatment outcomes from 200 participants in Italy. The goal is to better understand how…

This study looks at how a dissolvable implant used to correct foot deformities in children and teens holds up over time. Researchers will use MRI scans and clinical exams to see if the implant has broken down properly and how well the foot functions at least 5 years after surgery…

This study tests whether 3D computer simulation and custom-printed surgical tools can make bone correction surgeries more precise and safer. It involves 100 children, teens, and young adults with rare limb deformities. Researchers will compare planned corrections to actual result…

This study looks at why some knee replacements loosen and fail without infection, a problem called aseptic loosening. Researchers will review X-rays and registry data from 31 patients who had revision surgery. The goal is to understand the causes and measure the financial burden …