Knee pain showdown: PRP vs. hyaluronic acid – which injection works better?

NCT ID NCT04937998

Recruiting now Symptom relief Sponsor: Istituto Ortopedico Rizzoli Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two common knee injections—platelet-rich plasma (PRP) and hyaluronic acid (HA)—for treating osteoarthritis behind the kneecap. About 166 adults aged 30–65 will receive a single injection and be followed for 12 months to see which provides better pain relief and knee function. The goal is to find a more effective non-surgical option for this specific type of knee arthritis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Platelet-rich plasma (PRP) or hyaluronic acid injection
What this could lead to: If PRP works better, it could offer a longer-lasting option for knee pain relief without surgery.
What could go wrong: This is a small, early-stage comparison study. PRP may not be more effective than hyaluronic acid, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PATELLOFEMORAL OSTEOARTHRITIS

Contacts and locations

Locations

Istituto Ortopedico Rizzoli
RECRUITING

Bologna, Italy

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