New knee implant under review: could it ease arthritis pain?
NCT ID NCT04817969
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing the Persona Ti-Nidium knee implant in 240 people who need total knee replacement due to conditions like osteoarthritis or rheumatoid arthritis. The goal is to see if the implant is safe and improves knee function and pain. Participants will be followed over time to track their recovery and any complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Persona Ti-Nidium Total Knee System (a knee implant device)
- What this could lead to
- If successful, this could confirm that the Persona Ti-Nidium knee implant is safe and works well for people needing knee replacement surgery.
- What could go wrong
- This is a post-market study, so the device is already approved. However, it may not work for everyone, and risks like infection, implant loosening, or ongoing pain are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Denver Hip & Knee, Inc.
Parker, Colorado, 80134, United States
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Duke University
Durham, North Carolina, 27708, United States
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MedStar Health Research Institute
Hyattsville, Maryland, 20782, United States
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Mississippi Sports Medicine and Orthopaedic Center
Jackson, Mississippi, 39202, United States
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Monument Health Rapid City Hospital, Inc.
Rapid City, South Dakota, 57701, United States
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New Mexico Orthopaedic Associates
Albuquerque, New Mexico, 87110, United States
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Rothman Orthopaedic Institute
Philadelphia, Pennsylvania, 19107, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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