Nose cells could fix your knee: new implant trial launches

NCT ID NCT06163573

Recruiting now Disease control Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tests whether an implant made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis) better than standard platelet-rich plasma injections. 75 adults aged 18–65 with moderate knee arthritis will be randomly assigned to receive either the implant or injections. The main goal is to see if the implant improves knee pain and function over 24 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nasal cartilage implant (autologous nasal chondrocyte tissue-engineered cartilage graft)
What this could lead to: If successful, this could offer a new, longer-lasting treatment option for knee osteoarthritis that uses the patient's own nasal cells to repair damaged cartilage.
What could go wrong: This is an early phase II trial with only 75 people, so results may not apply to everyone. The implant requires surgery, and there is a risk of side effects or the graft not working as hoped.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PATELLOFEMORAL OSTEOARTHRITIS

Contacts and locations

Locations

Crossklinik
RECRUITING

Basel, 4054, Switzerland
Hôpitaux universitaires de Genève
RECRUITING

Geneva, 1205, Switzerland
Orthopädische Klinik König-Ludwig-Haus
NOT_YET_RECRUITING

Würzburg, 97074, Germany
Ospedale Regionale di Lugano
RECRUITING

Lugano, 6962, Switzerland
Poliklinika Ivković
RECRUITING

Zagreb, 10000, Croatia
Poliklinika Ortho Plus
RECRUITING

Zagreb, 10000, Croatia
Sportclinic, Klinik Hirslanden
RECRUITING

Zurich, 8032, Switzerland
University Hospital Basel
RECRUITING

Basel, 4031, Switzerland
Universitätsklinikum Freiburg
NOT_YET_RECRUITING

Freiburg im Breisgau, 79106, Germany

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