Nose cartilage could fix your knee: new trial underway

NCT ID NCT06576583

Recruiting now Disease control Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase II trial tests whether a graft made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis). 150 adults with knee pain will receive either the nasal cartilage implant or standard care (a minor procedure or partial knee replacement). The main goal is to see if the implant improves knee function and pain over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nasal cartilage cells grown into a graft (N-TEC)
What this could lead to: If successful, this could offer a new, less invasive treatment option for knee osteoarthritis that uses the patient's own nasal cartilage to repair damaged knee joints.
What could go wrong: This is an early phase II trial with only 150 participants, so results may not apply to everyone. The procedure is complex and may not work better than existing treatments.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PATELLOFEMORAL OSTEOARTHRITIS

Contacts and locations

Locations

Crossklinik
RECRUITING

Basel, 4054, Switzerland
Department of Orthopaedics, University of Gothenburg (UGOT)
RECRUITING

Mölndal, 80, Sweden
Evangelisches Waldkrankenhaus Spandau
NOT_YET_RECRUITING

Berlin, 13589, Germany
Fondazione Policlinico Universitario Campus Bio-Medico
NOT_YET_RECRUITING

Rome, 00128, Italy
IRCCS Ospedale Galeazzi-Sant'Ambrogio
RECRUITING

Milan, 20157, Italy
Maastricht University Medical Center
NOT_YET_RECRUITING

Maastricht, 6229 HX, Netherlands
Orthopedic Clinic König-Ludwig-Haus
RECRUITING

Würzburg, 97074, Germany
Orthopedic Hospital Vienna-Speising
RECRUITING

Vienna, 1130, Austria
University Hospital Basel
RECRUITING

Basel, 4031, Switzerland
University Hospital Sveti Duh
NOT_YET_RECRUITING

Zagreb, 10000, Croatia
Zeromski hospital
RECRUITING

Krakow, 31-913, Poland

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