University Hospital, Basel, Switzerland

This study is testing whether it is safe to temporarily stop a common heart medication called a beta-blocker in patients getting a TAVR procedure to replace a narrowed heart valve. Researchers want to see if this pause lowers the chance of needing a permanent pacemaker after the …

This study is testing a new treatment for arthritis in the kneecap joint. Doctors take cartilage cells from a patient's nose, grow them into a new tissue patch in a lab, and then implant it into the damaged knee. The goal is to see if this new implant works better than current st…

This study is testing if adding a 5-day course of the antibiotic linezolid to standard treatment improves outcomes for adults hospitalized with Staphylococcus aureus bloodstream infections. The goal is to see if this combination helps more patients survive, recover their normal f…

This study aims to help people living with HIV quit smoking by offering them different nicotine replacement options like e-cigarettes, nicotine pouches, or patches. Researchers want to see which approach works best to help participants stop smoking tobacco cigarettes for at least…

This international study aims to find out if specialized surgery provides better quality of life than standard therapy alone for chronic arm swelling (lymphedema) after breast cancer treatment. It will enroll 280 patients who have had swelling for over 3 months despite standard c…

This study aims to see if training local village health workers to provide regular screening and basic care can improve the management of chronic diseases like high blood pressure and diabetes in rural Lesotho. It will enroll up to 17,500 residents from selected villages. The hea…

This study is testing whether adding a common blood pressure medication (nicardipine) to standard liver cancer treatment helps kill tumors more completely. Researchers want to see if this combination helps overcome the cancer's resistance to chemotherapy. The trial involves adult…

This study is testing whether using telemedicine (remote monitoring via phone or tablet) can help doctors safely adjust heart failure medications for patients after they leave the hospital. It compares this remote approach to usual care to see if it leads to better medication use…

This study is testing if a lower, gentler dose of steroids can safely treat liver inflammation that sometimes occurs as a side effect of powerful cancer immunotherapies. It will involve about 63 adult cancer patients who develop this specific liver issue. The goal is to see if th…

This study is testing whether people with inflammatory or autoimmune diseases can safely stop their steroid medication (like prednisone) suddenly, compared to the standard method of slowly reducing the dose over four weeks. It involves over 500 adult patients who have been on ste…

This international trial is comparing two different approaches for treating breast cancer that has spread to the lymph nodes under the arm. It will test whether a less extensive surgery followed by radiation leads to better quality of life and less arm swelling than the standard,…

This study is testing whether gently stretching the stomach's exit valve during esophageal cancer surgery helps patients recover faster. The goal is to prevent a common complication where the stomach empties too slowly after surgery, which can delay healing and prolong hospital s…

This international trial is for people who have had a severe stroke caused by a large blocked brain artery, and where the standard procedure to remove the clot has failed. It compares two approaches: immediately placing a permanent stent to prop the artery open, or continuing wit…

This study is testing if a new implant made from a patient's own nasal cartilage cells can help repair damaged knee cartilage and control arthritis pain. It will compare this engineered cartilage graft to standard platelet-rich plasma (PRP) injections in 75 adults with arthritis …

This study is collecting long-term information on a treatment called Rezum, which uses steam injections to shrink an enlarged prostate and relieve urinary symptoms. It will follow 1000 men for five years after their procedure to see how well it works, how long the benefits last, …

This study is testing if feeding critically ill patients in scheduled meals (intermittent bolus) is better than the standard continuous drip feeding at preventing dangerous muscle loss. Researchers will compare the two methods in 68 ICU patients to see which one helps patients re…

This study is testing whether adding the drug Nintedanib to standard treatment is safe and tolerable for patients who develop severe lung scarring (BOS) after a stem cell transplant. The trial will enroll 20 participants who will take Nintedanib daily for 12 months. Researchers w…

This study aims to see if different treatment approaches with the standard drug cabergoline affect blood sugar and insulin levels in people with prolactinoma, a common benign pituitary tumor. It will enroll 60 adults who are either newly diagnosed or already on stable treatment. …

This study is testing if a drug called empagliflozin, usually used for diabetes, can help raise low sodium levels in the blood. It will involve 172 hospitalized patients whose low sodium is linked to conditions like heart failure, liver disease, or a hormone imbalance (SIADH). Pa…

This early-stage study is testing whether giving specially grown immune cells from a stem cell donor can help prevent cancer from coming back after a transplant for acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The main goal is to see if this approach is safe a…

This study tests a personalized treatment for advanced non-small cell lung cancer patients who have exhausted standard options. Doctors collect immune cells from a patient's tumor, grow billions of them in a lab, then infuse them back into the patient to attack the cancer. The tr…

This study aims to find a safer way to diagnose oxytocin deficiency, which is common in people with AVP-Deficiency (central diabetes insipidus) and may cause anxiety and low mood. Researchers are testing if two common oral estrogen pills can safely trigger the release of oxytocin…

This study is testing if two new measurements, called aSID and ChU, can help doctors more accurately figure out why hospitalized patients on certain blood pressure pills develop low sodium levels. Researchers will compare treatment guided by these new measurements against current…

This study is testing a new type of MRI scan to see if it can better find and measure damage (lesions) in the spinal cord of people with multiple sclerosis (MS). Researchers will compare the new scan to standard MRI methods to see if it provides clearer pictures and more consiste…

This study is testing two simple methods to prevent low sodium levels, a common and potentially serious complication after pituitary gland surgery. Researchers want to see if having patients drink protein supplements or strictly limit their fluid intake for a few days after surge…

This study is testing a new peer-led workshop program for young people in vocational training in Zambia, Zimbabwe, and South Africa. The goal is to see if group sessions focused on reducing substance use and promoting fairer gender beliefs can improve health and life outcomes. It…

This study is testing if slowly increasing the dose of an anesthesia drug (propofol) based on a patient's needs leads to more stable blood pressure during surgery compared to a standard starting dose. It involves 320 patients aged 55 and older having non-heart surgery. The goal i…

This study is testing whether an oxytocin nasal spray can help reduce anxiety and improve social and emotional functioning in adults with central diabetes insipidus. Participants will receive either the oxytocin spray or a placebo spray for two weeks while continuing their standa…

This study is testing whether using a smaller chest tube after minimally invasive lung cancer surgery causes less pain than the standard larger tube. Researchers will enroll 124 patients who are having part of their lung removed and randomly assign them to receive either a small …

This study is testing a 7-day wellness retreat designed for women who have finished treatment for breast or gynecological cancers. It aims to see if the retreat is practical to study and if it helps improve survivors' quality of life, reduce stress, and ease symptoms like fatigue…

This study is testing whether a nasal spray containing oxytocin, often called the 'bonding hormone,' can improve sexual well-being and intimacy. It involves 42 adults, including patients with a rare hormone deficiency (AVP-D) and healthy volunteers. Participants will use the spra…

This study aims to understand how different types of breast surgery affect patients' quality of life over many years. Researchers will follow 1,000 patients for up to ten years after their surgery, asking them to report on their satisfaction and well-being. The goal is to identif…

This study aims to see if artificial intelligence (AI) can measure a person's hydration status as well as or better than human doctors using a simple ultrasound scan. Researchers will compare AI-guided measurements of a major vein in the abdomen to those made by both experienced …

This study aims to understand if music enhanced with special sound technology can safely increase oxytocin levels in the blood. Researchers will compare the effects of this enhanced music to regular music in 22 healthy adults and people with a hormone condition called AVP-deficie…

This worldwide registry study aims to understand a rare but serious complication that can occur during a common stroke treatment called thrombectomy, where a blood vessel tears. Researchers will collect data from 1,000 stroke patients to identify what makes this tear more likely …

This study aims to understand how breathing support and lying face down affect blood flow in healthy people. Researchers will use a special ultrasound scan called the VExUS score to measure blood congestion in veins. The goal is to gather basic knowledge to help doctors better mo…

This Swiss study aims to understand how a pregnant person's immune system accepts the growing fetus without attacking it. Researchers will track 100 women undergoing IVF treatment, analyzing their blood before pregnancy and during early pregnancy or miscarriage. The goal is to id…

This Swiss study is exploring whether caffeine can boost the activity of 'brown fat,' a special type of fat that burns calories to generate heat. Researchers will give healthy volunteers either caffeine or a placebo, then expose them to mild cold to activate this brown fat. They …

This study aims to understand the immediate physical and mental effects of a substance called 5-MeO-DMT when given to healthy people. Forty participants will receive either the substance or a placebo through an IV, and researchers will closely monitor their vital signs, feelings,…

This research study aims to understand how energy production in cancer cells and immune cells affects treatment resistance and outcomes in blood cancers like leukemia. Researchers will analyze blood and bone marrow samples from 350 patients with various blood cancers to identify …

This research aims to understand how dangerous antibiotic-resistant bacteria spread in hospitals and the community. Scientists will analyze the genetic code of bacteria from patients, hospital wastewater, and food to trace where infections come from. The goal is to gather evidenc…

This study aims to understand if a woman's physical activity, fitness level, heart health, and mental well-being are linked to her chances of getting pregnant through fertility treatments like IVF. Researchers will observe 115 women undergoing treatment, tracking their exercise, …

This study aims to understand why some patients experience brain-related problems like confusion, stroke, or memory decline after heart surgery. Researchers will monitor 500 patients' brain blood flow during surgery to see if keeping blood pressure within a personalized 'safe zon…

This study aims to improve how emergency departments assess patient risk by testing a new tool. Researchers will observe over 6,400 patients at a Swiss hospital, recording their symptoms and tracking outcomes like hospital admission and survival. The goal is to help doctors make …

This study aims to understand a new compound called DDH-LSD, which is similar to LSD but may have shorter-lasting effects. Researchers will give both DDH-LSD and LSD to healthy volunteers in a controlled setting to measure how the body processes each drug and compare their subjec…

This study aims to better understand how multiple sclerosis (MS) starts and progresses by collecting detailed health data from about 100 patients in Switzerland. Participants will use a smartphone app to track symptoms and complete regular tests, while researchers analyze this in…

This study aims to understand a common but often hidden problem: heart injuries that occur after major non-heart surgery. Researchers will follow nearly 20,000 high-risk patients for a year, using blood tests to detect these silent injuries. The goal is to learn how often they ha…