University Hospital, Basel, Switzerland

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This early-phase study tests a radioactive drug (177Lu-PP-F11N) that seeks out and attaches to cancer cells in people with advanced medullary thyroid cancer and certain other neuroendocrine tumors. The goal is to see if the drug can help image tumors and deliver targeted radiatio…

This phase III trial tests whether a less extensive lymph node surgery (tailored axillary surgery) followed by radiotherapy works as well as the standard full lymph node removal in women with breast cancer that has spread to the lymph nodes. The study involves 1,500 participants …

This early-phase trial tests a new treatment for people with advanced melanoma that cannot be removed by surgery or has spread. The therapy uses a patient's own immune cells (tumor-infiltrating lymphocytes) grown in a lab and then given back along with a drug called ANV419 to hel…

This trial tests whether trained village health workers, using a smartphone app, can effectively manage high blood pressure in rural Lesotho. About 1,350 participants with either uncontrolled or controlled hypertension will receive either community-based care (medication and moni…

This trial tests whether trained village health workers, using a smartphone app, can provide effective type 2 diabetes care in rural Lesotho. 252 adults with diabetes will either receive community-based care (lifestyle advice, metformin, statins) or be referred to a clinic. The g…

This study looks at whether liquid biopsies—simple blood tests that detect tumor DNA—can be used during regular doctor visits for people with advanced solid tumors. Researchers will collect blood samples from 159 patients and measure ctDNA levels to see how often the test finds t…

This study compares two blood test schedules for diagnosing heart attacks in the emergency room: the standard 3-hour test and a newer 1-hour test. Over 64,000 adults with chest pain will be enrolled to see if the faster test is just as safe and accurate. If it works, patients cou…

This study compares a new, non-invasive PET-MRI scan to the standard invasive test (IPSS) for finding pituitary tumors in people with Cushing's disease. About 43 adults with confirmed Cushing's will get both tests to see which is more accurate. The goal is to make diagnosis safer…

This study was designed to see if two drugs, empagliflozin and anakinra, could help people with prediabetes who experience low blood sugar after eating. The trial planned to give a single dose of each drug before a test meal and measure symptoms. However, the study was withdrawn …

This study looks at how often new pupil differences (one pupil larger than the other or not reacting normally) appear in adult intensive care patients. Researchers will review medical records from 2013 to 2024 to see what these changes mean for diagnosis, treatment, and patient o…

This study reviewed the medical records of 532 adults who had a palliative care consult before, during, or after an ICU stay at a Swiss hospital between 2019 and 2024. Researchers looked at what led to the consult, how long patients stayed in the hospital, and what happened to th…

This study looks back at the medical records of 2,000 adults who were physically restrained in a Swiss intensive care unit between 2010 and 2023. The goal is to understand how often restraints are used, what problems they cause, and which patients are more likely to be restrained…

This study examines how often healthcare workers in a hospital's intensive care unit (ICU) experience physical, verbal, or sexual assaults from patients or their relatives. Researchers will review medical records of 865 adults who were in the ICU and had a reported incident of vi…

This study tests whether a new monitoring method can track brain blood flow in real time during major noncardiac surgery. Researchers will enroll 256 adults to see if the Medtronic Cotrending algorithm works reliably. The goal is to learn if this tool can help doctors keep the br…

This study looks at whether low blood pressure during major noncardiac surgery harms organs like the heart and kidneys. Researchers are using a non-invasive brain monitor to see if a personalized blood pressure target can be set. 650 patients at cardiovascular risk are being obse…

This study follows nearly 20,000 patients who had major non-cardiac surgery to see how often heart injury occurs and what happens a year later. Researchers are looking at death rates and major heart complications. The goal is to better understand who is at risk and how to improve…

This study looks at whether a new screening system can help doctors find heart complications early in high-risk patients after noncardiac surgery. Researchers will track 900 patients to see how well the screening works in practice and what it costs. The goal is to gather informat…

This study gives 20 healthy adults drinks containing sucrose (table sugar), glucose, fructose, or plain water, then measures how their bodies respond. Researchers track gut hormones, blood sugar, digestion speed, and other health markers. The goal is to understand the unique effe…

This pilot study compares the effects of daily erythritol (a sugar substitute) versus regular sugar on insulin resistance and blood clotting in 30 healthy adolescents aged 14-18. Participants consume either erythritol or sucrose for 5 weeks, and researchers measure changes in glu…

This study looks at how changing the length of the small intestine re-routed during gastric bypass surgery affects metabolism and inflammation. Researchers will compare two surgical techniques in 50 people with severe obesity and also include 15 healthy lean individuals as a comp…

This study looks at why some people have Long COVID symptoms like fatigue and brain fog. It also tests if a 12-week smartphone app with breathing exercises, relaxation, and energy management can help. About 120 adults with Long COVID are taking part to share health data and try t…

This study surveys 530 prolactinoma patients and their doctors to understand real-world treatment experiences, side effects, and preferences. The goal is to identify gaps in care and guide future research for better, more personalized treatment strategies. No new treatments are t…