University Hospital, Basel, Switzerland

This phase II trial tests whether an implant made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis) better than standard platelet-rich plasma injections. 75 adults aged 18–65 with moderate knee arthritis will be randomly assigned to rec…

This study looks at whether adding a drug called Wilate (a von Willebrand factor concentrate) to standard platelet transfusions can reduce bleeding and the need for more blood products in intensive care patients. About 120 adults who need platelets during or after surgery will be…

This study compares two microsurgical techniques (LVA and VLNT) against standard conservative therapy for chronic arm swelling after breast cancer treatment. Researchers will measure quality of life in 280 participants one year after surgery. The goal is to see if surgery provide…

This study tests whether offering a choice of e-cigarettes, nicotine pouches, or nicotine patches helps people with HIV stop smoking tobacco. About 972 participants in Switzerland will receive their preferred product free for 6 months, plus standard care. The main goal is to see …

This study looks at whether people with inflammatory or autoimmune diseases can safely stop taking steroids (like prednisone) right away instead of slowly reducing the dose over 4 weeks. The goal is to see if stopping quickly leads to more hospital visits or adrenal crises. About…

This study tests whether inflating a small balloon in the pylorus (the valve between stomach and small intestine) during minimally invasive esophageal cancer surgery can prevent delayed stomach emptying, a common complication. About 116 patients will be randomly assigned to recei…

This study tests whether adding the antibiotic linezolid to standard treatment improves outcomes for people with Staphylococcus aureus bloodstream infections. About 606 hospitalized adults will receive either linezolid or a placebo for five days. The goal is to see if the combina…

This phase II trial tests whether a graft made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis). 150 adults with knee pain will receive either the nasal cartilage implant or standard care (a minor procedure or partial knee replacement)…

This study tests whether adding nicardipine (a drug that blocks a cancer resistance protein) to standard chemoembolization (TACE) improves outcomes for people with liver cancer. About 152 adults with untreated liver tumors will be randomly assigned to receive either the standard …

This study compares two treatments for stroke patients whose brain arteries remain blocked after initial clot removal, due to underlying hardening of the arteries (atherosclerosis). About 498 participants will be randomly assigned to receive either urgent stenting or continued st…

This study tests a drug called nintedanib in 20 people who developed a lung condition called bronchiolitis obliterans syndrome after a stem cell transplant. Participants take the drug daily for 12 months alongside their usual medications. The main goal is to see if the drug is sa…

This study tests whether giving extra natural killer (NK) cells from a donor can safely help prevent leukemia or MDS from coming back after a stem cell transplant. About 10 adults with acute myeloid leukemia or myelodysplastic syndromes who don't have a fully matched donor will r…

This study tests whether using telemedicine (video or phone check-ins) can help doctors better adjust heart failure medications after patients leave the hospital. About 140 adults with heart failure and reduced pumping ability will be split into two groups: one gets usual care, t…

This study tests a therapy using a patient's own tumor-infiltrating lymphocytes (TILs) to treat advanced non-small cell lung cancer. Doctors collect immune cells from a tumor, grow them in a lab, and infuse them back after mild chemotherapy. The goal is to see if this slows cance…

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This trial tests a peer-led program called PEGISUS to reduce substance use and promote fair gender beliefs among 264 young people (ages 16-24) in vocational training in Zambia, Zimbabwe, and South Africa. Participants in peer groups will attend eight sessions, while a control gro…

This study looks at how different doses of the drug cabergoline affect blood sugar control in people with prolactinoma, a type of pituitary tumor. Researchers will randomly assign 60 adults to different treatment strategies and measure their glucose levels after a sugar drink. Th…

This study tests whether slowly increasing the dose of the anesthetic drug propofol based on a patient's needs keeps blood pressure more stable than giving a standard starting dose. Researchers will enroll 320 adults aged 55 and older having non-cardiac surgery. The goal is to se…

This study looks at whether low-dose prednisolone (a steroid) can safely treat liver inflammation (hepatitis) caused by immune checkpoint inhibitors in cancer patients. Researchers will enroll 63 adults with grade 2 or 3 immune-related hepatitis and give them 0.5-1 mg/kg of predn…

This study compares the standard flashlight pupil exam to a precise, automated pupillometer in 50 adults with suspected brain death. The goal is to see if the device catches details the human eye might miss. If it works, it could improve accuracy in declaring brain death.

This study compares a new diagnostic test using mannitol infusion to the standard hypertonic saline test for diagnosing the cause of polyuria-polydipsia syndrome (excessive urination and thirst). Researchers will enroll 144 adults to see if the mannitol test is as accurate and mo…

This study tests whether two new measurements, aSID and ChU, can help doctors better diagnose and treat low sodium levels in hospitalized patients taking thiazide diuretics for high blood pressure. Researchers will compare outcomes in 136 patients randomly assigned to either stan…

This study tests whether giving ICU patients 0.5 liters of wheat beer each evening for 6 days can lower their risk of developing delirium, compared to patients who receive water. Delirium is a sudden confused state common in intensive care. The trial will include 380 adults who h…

This study tests two simple methods—drinking less water or taking protein supplements—to prevent low sodium levels after pituitary surgery. Low sodium is a common complication that can cause confusion and other issues. About 282 adults having pituitary surgery will be randomly as…

This study tests whether giving melatonin at bedtime can help older ICU patients (55+) recover faster from hypoactive delirium, a state of confusion and low activity. Researchers will compare melatonin to a placebo in 190 patients, measuring how long delirium lasts and overall re…

This study compares two ways to treat breast cancer that has spread to nearby lymph nodes: targeted radiotherapy or surgical removal of the nodes. The goal is to see which approach better preserves arm function and reduces the risk of long-term arm swelling. About 1,060 adults wi…

This study follows 1000 men with an enlarged prostate who are receiving Rezum water vapor therapy, a minimally invasive steam treatment. The goal is to see how well it relieves urinary symptoms and improves quality of life over 5 years. Researchers will track symptom scores, urin…

This study tests whether a smaller 16F chest drain causes less pain than the standard 24F drain after minimally invasive lung surgery. About 124 adults having a lung lobe or segment removed will be randomly assigned to one drain size. Pain levels while coughing will be measured o…

This study tests whether an intensive follow-up program can improve bowel control and quality of life for people who have had rectal cancer surgery. About 140 adults who had surgery and a temporary colostomy will be split into two groups: one gets the intensive program with extra…

This study tests whether a nasal spray containing oxytocin can help reduce anxiety and improve emotional well-being in adults with central diabetes insipidus, a condition where the body lacks a key hormone. Participants will receive either oxytocin or a placebo spray for several …

This study tests whether low or moderate doses of LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either two moderate doses or two very low (placebo-like) doses of LSD in a double-blind setup. The goal is…

This study aims to find out whether DMT, a psychedelic drug, helps with depression because of the 'trip' itself or because of biological changes in the brain. 112 adults with major depression will receive DMT or a placebo, and some will also be sedated with propofol to block the …

This early-stage study explores whether MDMA (the active ingredient in ecstasy) can reduce pain. Twenty healthy volunteers will receive either MDMA or a placebo, while mild pain is created using small electrical pulses under the skin. Researchers will compare pain ratings between…

This phase 2 trial tests whether oxytocin nasal spray can improve sexual well-being in people with central diabetes insipidus, a condition that also causes oxytocin deficiency. The study includes 42 participants (patients and healthy controls) and uses a double-blind, placebo-con…

This study looks at whether keeping a patient's blood pressure within their personal safe range during heart surgery can reduce brain problems like confusion, stroke, or memory issues. Researchers will monitor 500 patients having heart surgery and track their blood pressure and b…

This study follows 600 transgender and gender-diverse people in Switzerland to learn what affects their health and happiness during gender-affirming treatments. Participants fill out surveys, give blood and other samples, and have routine check-ups. The goal is to find out which …

This observational study will collect data from the medical records of 1,000 adults treated for status epilepticus (a prolonged seizure emergency) at two Swiss hospitals between 2005 and 2023. Researchers aim to learn how factors like early treatment, monitoring, and complication…

This study examines how often advance directives—written instructions about a person's medical wishes—are used and followed in the intensive care unit (ICU). Researchers will review the digital medical records of about 2,000 adult patients treated in the ICU at a Swiss hospital b…

This study reviews the medical records of 100 adults who were treated for Guillain-Barre Syndrome (GBS) at a single hospital in Switzerland. The goal is to better understand how often GBS occurs, what symptoms and nerve problems people have, what treatments they receive, and how …

This registry will collect health information from 8,000 patients with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track what treatments patients receive and how they fare, including survival rates in the hosp…

This study looks at patients infected with carbapenemase-producing bacteria (CPB), a type of superbug resistant to many antibiotics. Researchers will track 100 patients over 20 years to see how often these infections occur, how quickly they are detected, and what factors increase…

This study uses whole genome sequencing to track how ESBL-producing bacteria (a type of drug-resistant germ) spread among hospital patients and staff. Researchers will analyze samples from 2,000 people to find out where infections come from and how they move. The goal is to bette…

This pilot study is testing whether a 7-day integrative oncology retreat called 'Via Shalva' is practical and helpful for women who have finished primary treatment for breast or gynecologic cancer. Thirty participants will either attend the retreat or receive usual follow-up care…

This study is comparing two approaches for people with recurrent, uncomplicated diverticulitis: elective surgery to remove part of the colon versus conservative (non-surgical) management. The goal is to see which approach leads to better bowel function and quality of life. Resear…

This study reviews medical records of 600 people with HER2+ or triple-negative breast cancer who had chemotherapy and still had cancer in their lymph nodes. The goal is to see if skipping additional lymph node removal (axillary dissection) leads to more cancer coming back in the …

This study is looking at whether tiny bits of tumor DNA (ctDNA) found in blood or urine can help doctors better understand and predict the course of a high-risk type of bladder cancer called T1G3. About 35 adults with this cancer will provide samples before, during, and after tre…

This registry is following 5,000 adults in Switzerland who were born with heart defects. The goal is to collect data on their long-term health, including complications and treatments. By tracking these patients over time, researchers hope to better understand the challenges they …

This early-phase study tests whether a natural odor, when inhaled, can be detected in the cerebrospinal fluid (the fluid around the brain and spine) within 30 minutes. 32 lean and obese adults who are already scheduled for a spinal tap will sniff either the odor or a placebo. The…

This study is creating a new tool to measure pain during cesarean delivery. Researchers will review existing research, ask experts for their input, and interview 15 women who recently had a C-section to make sure the tool reflects what patients actually experience. The goal is to…

This study reviews medical records of 1,000 patients who came to the hospital with sudden neurological symptoms like weakness, speech problems, or seizures. The goal is to find out how many are diagnosed with Functional Neurological Disorder (FND), a condition where the brain doe…

This study looks at whether fluid buildup in veins (congestion) affects blood flow in the smallest blood vessels after planned heart surgery. Researchers will monitor 40 adults in the ICU using ultrasound and other tools. The goal is to better understand these connections, not to…

The PREVENT study is a large, worldwide registry that will track 1,000 stroke patients who undergo a clot-removal procedure called thrombectomy. Researchers want to understand why a blood vessel sometimes gets poked during the procedure, causing dangerous bleeding. By studying me…

This study looks at a new compound called DDH-LSD, which is similar to LSD but is expected to wear off faster. Researchers will give 24 healthy adults DDH-LSD, LSD, or a placebo in random order to compare how long each lasts, how the body processes them, and what effects people f…

This pilot study is testing a new MRI technique called AMIRA to see if it can find spinal cord lesions in people with multiple sclerosis better than standard MRI. Ten participants will undergo both the new and standard scans. The goal is to improve how doctors detect and monitor …

This study looks at how the immune system helps the body accept a pregnancy during the first three months. Researchers will analyze blood samples from 100 women undergoing IVF to understand which immune cells and genes are linked to healthy pregnancies or miscarriages. The goal i…

This early-stage trial is testing how safe and tolerable intravenous 5-MeO-DMT is in 40 healthy adults aged 25-65. Participants receive either a low dose of the psychedelic or a placebo, and researchers monitor their subjective experiences, vital signs, and side effects. The goal…

This pilot study compares how well artificial intelligence (AI) and human sonographers can measure hydration status using ultrasound of the inferior vena cava. Fifty healthy adults will be scanned by both an experienced and a beginner sonographer, with and without AI assistance, …

This study tests whether music enhanced with sonic augmentation technology can increase oxytocin (a hormone linked to social bonding) with few side effects. Researchers will compare the modified music to regular music in 22 healthy adults and patients with AVP-deficiency. The goa…

This study looks at whether trained community health workers can effectively screen and manage chronic diseases like high blood pressure and diabetes in rural Lesotho. About 17,500 adults will take part, with health workers using simple tools and eHealth apps to monitor and refer…

This study is testing a tool that uses vital signs and patient mobility to better predict which emergency room visitors are at risk of dying within 30 days. Researchers will track over 6,000 adults who come to the ER to see if the tool helps doctors make faster, more accurate dec…

This study is testing whether taking estrogen pills (estradiol valerate or ethinylestradiol) can safely trigger the release of oxytocin, a hormone important for social bonding and childbirth. Researchers will measure oxytocin levels in 28 healthy volunteers and patients with AVP …

This study looks at whether taking 200mg of caffeine (about two cups of coffee) changes how active your brown fat is when you're mildly cold. Brown fat is a type of body fat that burns energy to generate heat. Researchers will scan 12 healthy adults to measure brown fat activity …

This study looks at how physical activity, fitness, stress, and sleep affect pregnancy rates in women receiving fertility treatments like IVF or IUI. Researchers will track 115 women aged 18-43 to see if being more active improves their chances of getting pregnant. The goal is to…

This study is collecting health data, smartphone app measurements, and biological samples from 100 people with multiple sclerosis. Researchers aim to find new biomarkers and digital tools to better understand how MS progresses and when it changes form. The goal is to improve moni…

This study looks at how metabolism in cancer and immune cells influences the bone marrow environment and treatment resistance in blood cancers like leukemia and myelofibrosis. Researchers will analyze samples from 350 participants to measure metabolites, lipids, and gene activity…

This study is tracking how breast surgery affects patients' quality of life and satisfaction. Researchers will survey 1000 adults who had any type of breast surgery at the University Hospital of Basel. The goal is to better understand the surgery's impact, not to test a new treat…

This study looks at how different breathing pressures and lying on your stomach change blood flow in the veins of 40 healthy adults. Researchers use ultrasound to measure vein congestion. The goal is to better understand these effects, not to treat any disease.

This study looks at whether it is safe to temporarily stop taking beta-blockers before a procedure called transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. About 498 adults who are scheduled for TAVR and have been on beta-blockers for at least a month will…