DMT for depression: scientists test if the trip matters
NCT ID NCT06927076
First seen Apr 04, 2026 · Last updated Jun 23, 2026 · Updated 11 times
Summary
This study tests whether DMT, a psychedelic drug, can reduce depression symptoms through its biological effects alone, or if the psychedelic experience is necessary. 112 adults with major depression will receive DMT or a placebo, some while sedated with propofol to block the psychedelic experience. Researchers will track mood changes over time to understand how DMT works.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Hospital Basel
RECRUITINGBasel, 4031, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
DMT (N,N-Dimethyltryptamine)
What this could lead to
If it works, this could point toward a treatment for depression that separates the psychedelic experience from the drug's biological effects.
What could go wrong
This is an early-phase study with only 112 participants, so results may not apply broadly. The use of propofol sedation adds complexity and risk.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.