Heart valve patients: should you stop your Beta-Blocker before surgery?

NCT ID NCT06472934

Recruiting now Knowledge-focused Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether it is safe to temporarily stop taking beta-blockers before a procedure called transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. About 498 adults who are scheduled for TAVR and have been on beta-blockers for at least a month will be randomly assigned to either pause or continue their medication. Researchers will track deaths, hospital readmissions for heart failure, strokes, and serious heart rhythm problems within 30 days after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: beta-blocker discontinuation
What this could lead to: If successful, this could show that temporarily stopping beta-blockers before TAVR is safe, potentially simplifying care for patients.
What could go wrong: This is a mid-sized trial, not a large Phase 3 study. Results may not apply to all patients, and pausing beta-blockers could increase risk of arrhythmias or heart failure.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS

Contacts and locations

Locations

Geneva University Hospitals
RECRUITING

Geneva, 1205, Switzerland
Herz- und Diabeteszentrum NRW Universitätsklinik
RECRUITING

Bad Oeynhausen, 32545, Germany
Inselspital, Bern University Hospital
RECRUITING

Bern, 3010, Switzerland
Kerckhoff-Klinik GmbH
RECRUITING

Bad Nauheim, 61231, Germany
Medical University of Graz
RECRUITING

Graz, 8036, Austria
University Hospital Basel
RECRUITING

Basel, 4031, Switzerland
University Hospital Salzburg
RECRUITING

Salzburg, 5020, Austria
University Hospital of Zürich
RECRUITING

Zurich, 8091, Switzerland
University Medical Center Freiburg
RECRUITING

Bad Krozingen, 79189, Germany
Universitätsklinikum Giessen und Marburg GmbH
RECRUITING

Giessen, 35392, Germany
Universitätsklinikum Schleswig-Holstein AöR
RECRUITING

Kiel, 24105, Germany

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