AORTIC STENOSIS

This study tests a new way to replace a narrowed heart valve (aortic stenosis) using a tube inserted through the armpit, guided only by ultrasound instead of X-rays. About 20 people with severe symptoms will be enrolled to see if this approach is safe and works well. If successfu…

This study tests if a monthly injection called pelacarsen can slow the worsening of aortic valve stenosis, a condition where the heart valve becomes stiff and narrow. It includes 502 adults aged 50-79 with high levels of Lp(a), a type of fat in the blood, and mild-to-moderate val…

This study tests whether using shockwave therapy on the leg artery before a TAVR heart valve procedure can lower the chance of bleeding or other complications. It involves 100 adults with severe aortic stenosis and heavily calcified arteries. The goal is to see if this extra step…

This study compares two newer heart valve devices (Evolut FX and Sapien 3 Ultra Resilia) in 1346 people with aortic stenosis, a condition where the heart's main valve narrows. Participants are randomly assigned to get one of the two valves. The main goal is to see if one valve is…

This study is for people with aortic stenosis whose first transcatheter heart valve has failed and needs to be replaced. Researchers want to see if a second, minimally invasive valve replacement (redo TAVR) is safe and works well. About 225 participants will be followed for one y…

This study compares two approaches for people with severe aortic stenosis who go into cardiogenic shock (the heart can't pump enough blood). One group gets a valve replacement within 12 hours of arriving at the hospital; the other gets standard care (stabilization in the ICU) and…

This study tests a new device called the Siegel TAVR system to replace a narrowed heart valve in people with severe aortic stenosis. About 1,025 participants with symptoms like chest pain or shortness of breath will receive the procedure. The goal is to see if the device reduces …

This study looks at whether replacing the aortic valve early in people with severe narrowing (aortic stenosis) who have no symptoms is better than waiting until symptoms appear. About 2,844 adults over 18 with severe but symptom-free aortic stenosis will be randomly assigned to e…

This study looks at whether a new sizing method (ABC Bicuspid Sizing Algorithm) helps doctors choose the right valve size for people with a bicuspid aortic valve who need a transcatheter aortic valve replacement (TAVR). About 290 participants will have their CT scans analyzed wit…

This study is testing whether an artificial intelligence (AI) program can detect aortic stenosis, a serious heart valve condition, just by looking at a standard electrocardiogram (ECG). Researchers will compare the AI's results with the usual diagnosis from echocardiograms. About…

This study tests an artificial intelligence (AI) tool to help doctors accurately diagnose severe low-gradient aortic stenosis, a heart valve condition that can be hard to detect. Researchers will enroll 300 adults with suspected disease and compare the AI's analysis of standard e…

This study tests whether artificial intelligence can make standard electrocardiograms (ECGs) better at finding two common heart conditions: aortic stenosis (a narrowed heart valve) and diastolic dysfunction (stiff heart muscle). Researchers at Mayo Clinic will enroll 2,000 adults…

This study will use wearable digital health devices to collect heart data from 5,000 adults with chronic heart conditions like heart failure, high blood pressure, and aortic stenosis. The goal is to observe how these conditions progress over time. No new treatments or medications…

This study aims to learn what causes aortic stenosis to get worse and how the heart changes after valve replacement. About 300 adults over age 50 with mild to severe aortic stenosis or a replacement valve will have heart scans every 6 to 12 months. Researchers will use special im…

This early study looks at whether a non-invasive test called impedance cardiography (the HYPERGRAPH test) can detect early signs of heart strain in people with aortic stenosis, a condition where the heart's main valve narrows. Researchers will compare the test results with MRI sc…

This study aims to see how well different heart ultrasound methods (2D and 3D echocardiography) compare to cardiac MRI for measuring heart function and valve problems. Researchers will enroll 200 adults with suspected moderate to severe heart valve disease. The goal is to improve…

This study tests whether artificial intelligence (AI) can help heart doctors read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to cardiologists in real time as they review scans for valve disease. The goal is to see if AI re…

This study looks at whether it is safe to temporarily stop taking beta-blockers (a common heart medication) in people undergoing a procedure called TAVR to replace a narrowed heart valve. About 498 adults with severe aortic stenosis will be randomly assigned to either stop or con…

This study looks at whether fixing a narrowed heart valve with a procedure called TAVI can improve the balance of bacteria in the gut. Researchers will collect stool and blood samples from 40 patients before and after the procedure to see if better blood flow changes the gut micr…

This study aims to identify biological differences between men and women with heart valve disease (aortic regurgitation, mitral regurgitation, or aortic stenosis) using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe valve disease to develop se…

This study is looking at whether certain blood markers of inflammation and fibrosis can help predict which patients will develop heart rhythm problems after a TAVI procedure (a minimally invasive heart valve replacement). Researchers will measure these markers before the procedur…

This study aims to find biological markers in the blood that could identify which patients with aortic stenosis (a narrowing of the heart's main valve) are at higher risk of heart problems, even before they feel symptoms. Researchers will collect blood samples and health informat…

This study looks at how scarring (fibrosis) develops in the heart muscle due to conditions like aortic stenosis, chemotherapy side effects, and carcinoid syndrome. Researchers will use special PET scans to detect this scarring early and see if it is actively forming. About 180 ad…