AORTIC STENOSIS

This study is testing whether it is safe to temporarily stop a common heart medication called a beta-blocker in patients getting a TAVR procedure to replace a narrowed heart valve. Researchers want to see if this pause lowers the chance of needing a permanent pacemaker after the …

This study is testing whether doctors can safely replace a narrowed heart valve using only ultrasound imaging to guide them, instead of X-rays. Researchers will perform this procedure on 20 patients with severe aortic stenosis, where the heart's main valve has become dangerously …

This study is testing whether a monthly injection called pelacarsen can slow down the worsening of a narrowed and hardened heart valve (aortic stenosis). It will involve about 502 adults aged 50-80 who have mild-to-moderate valve disease and a specific high blood marker. Particip…

This study is testing a new sizing tool to help doctors choose the right size and type of replacement heart valve for patients with a specific heart valve problem (bicuspid aortic stenosis). About 290 patients already scheduled for a minimally invasive valve replacement will have…

This large international trial aims to settle a major heart care question: is it better to replace a severely narrowed heart valve early, even when a patient feels fine, or to wait and watch? It will enroll over 2,800 adults with severe but symptomless aortic stenosis and randoml…

This study is testing if using a special shockwave device on a hardened leg artery before a heart valve procedure makes the process safer. It will compare 100 patients getting the shockwave treatment to those getting the standard access method. The main goal is to see if this red…

This study is looking at the safety and effectiveness of performing a second, minimally invasive heart valve replacement when the first implanted valve fails. It will enroll 225 patients whose previous transcatheter aortic valve is not working properly. The goal is to understand …

This study is testing whether artificial intelligence (AI) can help doctors find two common heart problems—aortic stenosis and diastolic dysfunction—more easily. Researchers will use the AI to analyze routine heart tests (ECGs) from 2,000 adults aged 60 and older. If the AI flags…

This study is testing a new artificial intelligence (AI) tool designed to help doctors more accurately diagnose a specific, hard-to-assess type of heart valve narrowing (aortic stenosis). About 300 adults already scheduled for a heart ultrasound will have their scans analyzed by …

This study is testing a quick, non-invasive heart scan called the HYPERGRAPH test. It aims to see if this scan can detect early signs of heart weakening in people with a narrowed aortic valve, before permanent scarring occurs. Researchers will compare the scan's results to detail…

This study aims to compare different types of heart scans to see which ones most accurately measure the severity of valve disease and heart muscle health. Researchers will enroll 200 adults with moderate or severe aortic or mitral valve problems. They will compare standard ultras…

This study aims to better understand and detect early heart scarring (fibrosis) in three specific heart conditions: aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans and blood tests on 180 participants to see if they c…

This study aims to learn what causes aortic stenosis (a stiffening heart valve) to progress and what happens after valve replacement. It will follow 300 people, including patients with mild to severe disease and healthy volunteers, for four years. Researchers will use advanced he…

This study aims to understand why some patients develop heart rhythm problems after a minimally invasive heart valve replacement (TAVI). Researchers will check blood samples from 102 patients before their procedure, looking for signs of inflammation and scarring that might predic…

This study aims to understand if a common heart procedure (TAVI) to fix a narrowed valve changes the types of bacteria living in a patient's gut. Researchers will enroll 40 patients and analyze their stool and blood samples before and after the procedure. The goal is to learn mor…

This study aims to understand how heart valve disease affects men and women differently using advanced heart scans. Researchers will analyze detailed heart images from 200 adults with moderate to severe valve problems to identify patterns that might explain why women often have w…

This study aims to identify blood markers that might predict which patients with aortic stenosis (a narrowing of the heart valve) are at higher risk for future heart problems, even before they feel symptoms. Researchers will collect blood samples and health information from 125 p…

This study aims to better understand how chronic heart conditions progress in daily life. It will enroll 5,000 adults in the U.S. who have conditions like heart failure or high blood pressure. Participants will wear special sensor patches to collect health data like heart rate an…