AORTIC STENOSIS
Clinical trials for AORTIC STENOSIS explained in plain language.
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Tiny tube vs. open chest: new heart valve battle for Low-Risk patients
Disease control OngoingThis study aims to see if a less invasive procedure to replace a narrowed heart valve is as safe and effective as traditional open-heart surgery for patients who are at low risk for surgery. About 1,000 patients with severe aortic stenosis will be randomly assigned to receive eit…
Matched conditions: AORTIC STENOSIS
Phase: NA • Sponsor: Edwards Lifesciences • Aim: Disease control
Last updated Apr 02, 2026 03:41 UTC
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New heart valve tested against established options
Disease control OngoingThis study tested the ACURATE Transfemoral Aortic Valve System, a device to replace a narrowed aortic valve without open-heart surgery. It compared the ACURATE valve against other commercially available replacement valves in nearly 2,000 patients with severe aortic stenosis. The …
Matched conditions: AORTIC STENOSIS
Phase: NA • Sponsor: Boston Scientific Corporation • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Heart valve showdown: which replacement is best for seniors?
Disease control OngoingThis study compares two ways to replace a narrowed heart valve in elderly patients with a small aortic opening. It randomly assigns 300 patients to either traditional open-heart surgery (SAVR) or a less invasive catheter-based procedure (TAVR). The goal is to see which method lea…
Matched conditions: AORTIC STENOSIS
Phase: NA • Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Heart doctors test timing of valve and artery fixes
Disease control OngoingThis study aims to find the safest order for two common heart procedures. It compares performing a procedure to open blocked heart arteries either before or after a minimally invasive valve replacement in patients who need both. The goal is to see which timing leads to fewer comp…
Matched conditions: AORTIC STENOSIS
Phase: NA • Sponsor: University of Zurich • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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New heart valve process put to the test in major safety trial
Disease control OngoingThis study is checking if changes to how replacement heart valves are made and packaged are safe and work well. It involves 777 adults who need to replace a damaged aortic or mitral valve. Researchers will follow participants for up to 5 years to see how the valves hold up and if…
Matched conditions: AORTIC STENOSIS
Phase: NA • Sponsor: Edwards Lifesciences • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New heart valve put to the test in major global study
Disease control OngoingThis study tested a new surgical heart valve (the Model 400) for people with a narrowed or leaky aortic valve. Over 1,300 patients received the valve and were followed for up to 5 years to see how safe it was and how well it improved their heart function and symptoms. The goal wa…
Matched conditions: AORTIC STENOSIS
Phase: NA • Sponsor: Medtronic Cardiac Surgery • Aim: Disease control
Last updated Mar 23, 2026 15:17 UTC
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Less invasive heart valve procedure put to the test against major surgery
Disease control ENROLLING_BY_INVITATIONThis study is comparing two procedures for treating a severely narrowed bicuspid aortic valve, a common heart defect. It will test if a less invasive procedure called TAVR, which uses a catheter to implant a new valve, is as safe and effective as traditional open-heart surgery (S…
Matched conditions: AORTIC STENOSIS
Phase: NA • Sponsor: Shanghai MicroPort CardioFlow Medtech Co., Ltd. • Aim: Disease control
Last updated Mar 19, 2026 14:56 UTC
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AI heart check aims to catch silent valve disease
Diagnosis ENROLLING_BY_INVITATIONThis study is testing whether artificial intelligence (AI) can help doctors find a serious heart valve condition called aortic stenosis earlier. Researchers will use portable heart tests (EKG and ultrasound) on 410 adults aged 70 and older during routine doctor visits. The goal i…
Matched conditions: AORTIC STENOSIS
Phase: NA • Sponsor: Yale University • Aim: Diagnosis
Last updated Mar 30, 2026 14:30 UTC
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Heart valve study targets Asian-Specific anatomy
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to understand which type of replacement heart valve works better for Asian patients, who often have smaller heart structures than Caucasian patients. It will compare two different valve technologies in 31 patients with severe aortic stenosis across multiple hospit…
Matched conditions: AORTIC STENOSIS
Sponsor: Prince of Wales Hospital, Shatin, Hong Kong • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Heart valve study seeks global clues: does your background affect your treatment?
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to understand how patients from different countries and backgrounds differ when they receive a TAVI procedure for a narrowed heart valve. Researchers will look back at the medical records and CT scans of 800 patients to compare their heart anatomy, blood test resu…
Matched conditions: AORTIC STENOSIS
Sponsor: Poznan University of Medical Sciences • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:40 UTC