AORTIC STENOSIS

This study is testing a new artificial heart valve (the Model 400 Avalus valve) in people with aortic valve disease, a condition where the heart's main valve doesn't work properly. About 1,300 participants received the valve during surgery. Researchers are checking how safe the v…

This study looks at nearly 1,000 people with severe aortic stenosis (a narrowed heart valve) and blocked heart arteries. It compares doing artery stenting before versus after valve replacement to see which order leads to fewer deaths, heart attacks, or other serious problems. The…

This study tests a new, less invasive heart valve (SAPIEN 3) for people with severe aortic stenosis who are at low risk for standard surgery. About 1,000 participants will be randomly assigned to get the new valve or traditional open-heart surgery. The goal is to see if the new v…

This study compares a newer, less invasive procedure called TAVR (replacing the heart valve through a tube) with traditional open-heart surgery for people with severe narrowing of a bicuspid aortic valve. About 452 participants aged 75 or younger will be randomly assigned to one …

This study compares two ways to replace a narrowed heart valve in patients 65 and older: a less invasive catheter-based method (TAVR) versus open-heart surgery (SAVR). The goal is to see which approach works better for people with small valve openings. About 300 participants will…

This trial tested a new device called ACURATE to replace a narrowed heart valve in nearly 2,000 people with severe aortic stenosis. The goal was to see if it was safe and effective compared to standard treatments. However, the company stopped the program in 2025 and will not seek…

This study tests a new device called DurAVR™ THV for people with severe aortic stenosis, a condition where the heart valve is narrowed. The goal is to see if the device is safe and can be placed successfully. The study involves 15 people aged 65 and older who need a valve replace…

This study tests whether artificial intelligence (AI) can spot a serious heart valve condition called aortic stenosis using portable electrocardiogram (ECG) and ultrasound devices. Researchers will enroll 410 adults aged 70 and older during routine primary care visits. The goal i…

This study tests a digital score to monitor aortic stenosis, a heart valve condition, in 210 adults aged 65 and older with early signs of the disease. Researchers will track changes in heart function over time using data from routine tests. The goal is to improve risk prediction,…

This study is an observational registry that will enroll 800 people with severe aortic stenosis who are scheduled for a TAVI procedure. Researchers will collect CT scans, blood tests, and medical data to compare how patients differ across countries. The goal is to better understa…

This study observes 31 Asian patients with aortic stenosis and small aortic valves who are getting TAVR. It compares two types of replacement valves (balloon-expandable vs. self-expanding) to see which works better in different Asian ethnic groups. The goal is to find the best ap…