New heart valve shows promise in early trial for aortic stenosis

NCT ID NCT05712161

Ongoing Disease control Sponsor: Anteris Technologies Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests a new device called the DurAVR™ heart valve in 15 people aged 65 and older with severe aortic stenosis, a condition where the heart's aortic valve becomes narrowed. The valve is implanted through a catheter (TAVR) without open-heart surgery. The main goals are to see if the procedure is safe and technically successful, measuring outcomes like death, stroke, and complications within 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DurAVR™ Transcatheter Heart Valve (THV) device
What this could lead to: If successful, this could provide a new, less invasive valve replacement option for people with severe aortic stenosis.
What could go wrong: This is a very early, small study (15 people) focused on safety and feasibility. The device may not work as well as existing valves, and risks include stroke, bleeding, or other complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve calcification aortic valve stenosis Aortic Valve, Calcification of

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS AORTIC VALVE CALCIFICATION SEVERE AORTIC VALVE STENOSIS SYMPTOMATIC AORTIC STENOSIS

Contacts and locations

Locations

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Columbia University Medical Center/NYPH

New York, New York, 10032, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Tucson Medical Center

Tucson, Arizona, 85712, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States

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