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Heart procedure timing trial aims to reduce complications

NCT ID NCT04310046

Ongoing Disease control Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial studies nearly 1,000 people with severe aortic stenosis and blocked coronary arteries who need both a valve replacement (TAVI) and artery stenting (PCI). Researchers want to see if doing the stenting before or after the valve replacement leads to fewer deaths, heart attacks, or other serious events. The goal is to find the safest timing for these two procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Procedure: PCI (stenting) and TAVI (valve replacement)
What this could lead to
If it works, this could help doctors choose the best order for these two heart procedures to reduce complications and improve outcomes.
What could go wrong
This is a large trial but still observational in timing; results may not apply to all patients or centers. Both procedures carry risks like bleeding or heart attack.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis Arterial Occlusive Diseases arteriosclerosis disorder cardiovascular disorder coronary artery disorder heart disorder myocardial ischemia vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS CORONARY ARTERY DISEASE PCI TAVI

Contacts and locations

Locations

  • Academic Teaching Hospital of the Friedrich-Alexander-University Erlangen-Nuremberg

    Fürth, Germany

  • Arnault Tzanck Institute Saint Laurent du Var

    Nice, France

  • Azienda Santa Croce e Carle

    Cuneo, Italy

  • Campus Kerckhoff of the Justus Liebig University Giessen

    Bad Nauheim, Germany

  • Cardiology Department Azienda Ospedaliera Ordine Mauriziano di Torino

    Turin, Italy

  • Cardiology Department, CHU Timone Marseille

    Marseille, France

  • Cardiovascular Center Bad Neustadt/Saale

    Bad Neustadt an der Saale, Germany

  • Geneva University Hospitals

    Geneva, Switzerland

  • German Heart Center of Charité

    Berlin, Germany

  • Heart Center Leipzig at University of Leipzig

    Leipzig, Germany

  • Heart and Vascular Centre Bad Bevensen

    Bad Bevensen, Germany

  • Heinrich-Heine University

    Düsseldorf, Germany

  • Helios Hospital Erfurt

    Erfurt, Germany

  • Helios Hospital Pforzheim

    Pforzheim, Germany

  • Herzzentrum Dresden

    Dresden, Germany

  • IRCCS Azienda Ospedaliera Metropolitana

    Genova, Italy

  • Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)

    Palermo, Italy

  • Justus-Liebig University of Giessen

    Giessen, Germany

  • Klinikum Fulda

    Fulda, Germany

  • Klinikum Ingolstadt

    Ingolstadt, Germany

  • Klinikum Klagenfurt am Wörthersee

    Klagenfurt, Austria

  • Krankenhaus der Barmherzigen Brüder

    Trier, Germany

  • LMU Munich

    Munich, Germany

  • Lausanne University Hospital

    Lausanne, Switzerland

  • Leiden University Medical Center

    Leiden, Netherlands

  • Municipial Hospital Karlsruhe

    Karlsruhe, Germany

  • Otto-von-Guericke University Magdeburg

    Magdeburg, Germany

  • Prosper Hospital

    Recklinghausen, Germany

  • Schüchtermann-Clinic Bad Rothenfelde

    Bad Rothenfelde, Germany

  • Segeberger Kliniken GmbH

    Bad Segeberg, Germany

  • TUM University Hospital

    Munich, Germany

  • The Clinique de l'Infirmerie Protestante

    Lyon, France

  • Thoraxcenter, Erasmus MC

    Rotterdam, Netherlands

  • Toulouse University Hospital

    Toulouse, France

  • Ulm University Heart Center

    Ulm, Germany

  • University Heart and Vascular Centre Hamburg

    Hamburg, Germany

  • University Hospital Basel

    Basel, Switzerland

  • University Hospital Bergmannsheil

    Bochum, Germany

  • University Hospital Dijon

    Dijon, France

  • University Hospital Erlangen

    Erlangen, Germany

  • University Hospital Jena

    Jena, Germany

  • University Hospital Regensburg

    Regensburg, Germany

  • University Hospital Schleswig-Holstein

    Kiel, Germany

  • University Hospital Zürich, Cardiology Department

    Zurich, 8091, Switzerland

  • University of Oldenburg

    Oldenburg, Germany

  • Universitäts-Herzzentrum Freiburg Bad Krozingen, Freiburg & Bad Krozingen

    Bad Krozingen, Germany

  • Universitätsklinikum Frankfurt

    Frankfurt, Germany

  • Zentralklinik Bad Berka

    Bad Berka, Germany

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