Less invasive heart valve replacement may be better for seniors with small valves

NCT ID NCT03383445

Ongoing Disease control Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways to replace a narrowed heart valve in elderly patients (65+) who have a small valve opening. One method is less invasive (TAVR, through a tube in an artery), the other is open-heart surgery. The goal is to see which approach gives better blood flow and fewer complications like stroke or bleeding. About 300 participants will be randomly assigned to one of the two procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR)
What this could lead to: If TAVR proves better, it could become the preferred, less invasive option for elderly patients with small aortic valves, reducing complications and improving heart function.
What could go wrong: This is a mid-stage trial with 300 participants, so results may not apply to all patients. Both procedures carry risks like bleeding, stroke, or valve mismatch.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve disorder aortic valve insufficiency aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC REGURGITATION AORTIC STENOSIS DEGENERATIVE AORTIC VALVE DISEASE

Contacts and locations

Locations

IUCPQ

Québec, Quebec, G1V 4G5, Canada

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