AORTIC STENOSIS

This study looks at how safe and effective the SAPIEN 3 heart valve is for people with a certain type of bicuspid aortic valve (Type-0) that causes narrowing. About 170 people in China will be observed after the procedure to track serious problems like death, stroke, or needing t…

This study tests a new device called the EmStop Embolic Protection System, designed to capture and remove debris that may break loose during a minimally invasive heart valve replacement (TAVR) for aortic stenosis. About 663 people will be enrolled to see if the device reduces the…

This study will follow 500 adults with severe aortic stenosis who receive a new type of heart valve (SAPIEN 3 Ultra Resilia) during a minimally invasive procedure called TAVR. Researchers will check how well the valve works and how safe it is over 10 years. The goal is to see if …

This study tests whether two common heart failure drugs, dapagliflozin and spironolactone, can help the heart recover more fully after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months after their valve surgery.…

This study tests whether using a second balloon inflation (called 'double tap') during a heart valve replacement procedure called TAVI helps the new valve open more fully. The trial will include 250 adults with severe aortic stenosis. Researchers will compare standard TAVI to TAV…

This study looks at whether a common heart valve replacement procedure (TAVI) is safe when done in hospitals that do not have heart surgery available on-site. Currently, the standard is to have surgery backup available. The trial will enroll 600 people with severe aortic stenosis…

This study compares two ways to guide a minimally invasive heart valve replacement (TAVR) in older adults with aortic stenosis. One method uses standard X-ray guidance, while the other uses only ultrasound (echocardiography) to reduce kidney damage from contrast dye and radiation…

This study looks at whether advanced heart pressure wave measurements can help predict how well people recover after a TAVR procedure for severe aortic stenosis. Researchers will measure wave patterns during the standard procedure and track participants' quality of life and heart…

This study looks at whether a common heart valve replacement procedure (TAVI) can be safely performed in hospitals that do not have a cardiac surgery team on site. Currently, TAVI is only done in hospitals with surgery backup, which can limit access and cause long waits. The tria…

This study looks at two common ways to place a new heart valve (TAVI) in people with severe aortic stenosis. The goal is to see which method helps the valve line up better with the heart's natural openings, reducing the chance of blocking blood flow to the heart arteries. About 4…

This study looks at 143 older adults with severe aortic stenosis (a narrowed heart valve) to see how many also have cardiac amyloidosis (abnormal protein buildup in the heart). Researchers will compare symptoms and outcomes between those with only valve disease and those with bot…

This study is a registry that will observe 600 people with severe aortic stenosis who cannot have TAVI through the usual leg artery. Instead, doctors will use other arteries (like in the neck or chest) to replace the heart valve. The goal is to track how safe and effective these …