Can a monthly shot slow stiff heart valves? new trial aims to find out.

NCT ID NCT05646381

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a monthly injection called pelacarsen to see if it can slow the worsening of calcific aortic valve stenosis, a condition where the heart valve becomes stiff and narrow. About 502 adults aged 50-79 with high levels of lipoprotein(a) and mild-to-moderate valve disease will receive either the drug or a placebo for 3 years. The main goal is to measure changes in blood flow through the valve and calcium buildup using heart scans.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS

Contacts and locations

Locations

AA Medical Research Center
RECRUITING

Flint, Michigan, 48504, United States
Advanced Research for Health Improvement LLC
WITHDRAWN

Naples, Florida, 34102, United States
Brigham and Womens Hosp Harvard Med School
RECRUITING

Boston, Massachusetts, 02115, United States
Brigham and Womens Hosp Harvard Med School
RECRUITING

Boston, Massachusetts, 02115, United States
Capital Cardiology Associates
RECRUITING

Albany, New York, 12211, United States
Cardiovascular Res Found
RECRUITING

Beverly Hills, California, 90210, United States
Carient Heart and Vascular
RECRUITING

Manassas, Virginia, 20109, United States
Excel Medical Clinical Trials LLC
WITHDRAWN

Boca Raton, Florida, 33434, United States
Flourish Clinical Resrch Covin
RECRUITING

Covina, California, 91723, United States
Flourish Res Acq LLC North Miami
RECRUITING

Miami, Florida, 33138, United States
Heart Center Research Llc
RECRUITING

Huntsville, Alabama, 35801, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Icahn School of Med at Mt Sinai
RECRUITING

New York, New York, 10029, United States
Inpatient Research Clinical LLC
RECRUITING

Miami Lakes, Florida, 33014, United States
Lindner Ctr At The Christ Hosp
RECRUITING

Cincinnati, Ohio, 45219, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Midwest Heart and Vascular Spec
RECRUITING

Overland Park, Kansas, 66211, United States
Minneapolis Heart Institute
WITHDRAWN

Minneapolis, Minnesota, 55407, United States
National Heart Institute
RECRUITING

Beverly Hills, California, 90211, United States
New York Presbyterian Hospital
ACTIVE_NOT_RECRUITING

New York, New York, 10021, United States
Nova Clinical Research LLC
RECRUITING

Bradenton, Florida, 34209, United States
Novartis Investigative Site
RECRUITING

Innsbruck, Tyrol, 6020, Austria
Novartis Investigative Site
WITHDRAWN

Linz, 4021, Austria
Novartis Investigative Site
RECRUITING

Vienna, 1100, Austria
Novartis Investigative Site
RECRUITING

Vienna, 1190, Austria
Novartis Investigative Site
RECRUITING

Vienna, A 1090, Austria
Novartis Investigative Site
RECRUITING

Genk, Limburg, 3600, Belgium
Novartis Investigative Site
RECRUITING

Yvoir, Namur, 5530, Belgium
Novartis Investigative Site
RECRUITING

Aalst, Oost Vlaanderen, 9300, Belgium
Novartis Investigative Site
RECRUITING

Kortrijk, West-Vlaanderen, 8500, Belgium
Novartis Investigative Site
RECRUITING

Roeselare, West-Vlaanderen, 8800, Belgium
Novartis Investigative Site
RECRUITING

Cambridge, Ontario, N1R 6V6, Canada
Novartis Investigative Site
RECRUITING

North York, Ontario, M6B 3H7, Canada
Novartis Investigative Site
RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Novartis Investigative Site
RECRUITING

Québec, Quebec, G1V 4G5, Canada
Novartis Investigative Site
RECRUITING

Hradec Králové, 500 02, Czechia
Novartis Investigative Site
RECRUITING

Jaroměř, 551 01, Czechia
Novartis Investigative Site
RECRUITING

Prague, 128 08, Czechia
Novartis Investigative Site
RECRUITING

Prague, 14021, Czechia
Novartis Investigative Site
RECRUITING

Prague, 150 06, Czechia
Novartis Investigative Site
RECRUITING

Esbjerg, 6700, Denmark
Novartis Investigative Site
RECRUITING

Hvidovre, 2650, Denmark
Novartis Investigative Site
RECRUITING

Roskilde, 4000, Denmark
Novartis Investigative Site
RECRUITING

Viborg, 8800, Denmark
Novartis Investigative Site
RECRUITING

Paris, 75012, France
Novartis Investigative Site
RECRUITING

Paris, 75013, France
Novartis Investigative Site
RECRUITING

Paris, 75015, France
Novartis Investigative Site
RECRUITING

Pessac, 33604, France
Novartis Investigative Site
RECRUITING

Poitiers, 86021, France
Novartis Investigative Site
RECRUITING

Rennes, 35033, France
Novartis Investigative Site
RECRUITING

Frankfurt am Main, Hesse, 60594, Germany
Novartis Investigative Site
RECRUITING

Kaiserslautern, Rhineland-Palatinate, 67655, Germany
Novartis Investigative Site
RECRUITING

Dresden, Saxony, 01099, Germany
Novartis Investigative Site
RECRUITING

Leipzig, Saxony, 04289, Germany
Novartis Investigative Site
RECRUITING

Ahaus, 48683, Germany
Novartis Investigative Site
RECRUITING

Berlin, 13353, Germany
Novartis Investigative Site
RECRUITING

Bonn, 53105, Germany
Novartis Investigative Site
RECRUITING

Essen, 45147, Germany
Novartis Investigative Site
RECRUITING

Hamburg, 20246, Germany
Novartis Investigative Site
RECRUITING

Hamburg, 22763, Germany
Novartis Investigative Site
WITHDRAWN

Lüneburg, 21339, Germany
Novartis Investigative Site
RECRUITING

Mannheim, 68165, Germany
Novartis Investigative Site
RECRUITING

München, 80636, Germany
Novartis Investigative Site
RECRUITING

Münster, 48149, Germany
Novartis Investigative Site
RECRUITING

Oldenburg, 26133, Germany
Novartis Investigative Site
RECRUITING

Beersheba, 8457108, Israel
Novartis Investigative Site
RECRUITING

Haifa, 3104802, Israel
Novartis Investigative Site
RECRUITING

Haifa, 3109601, Israel
Novartis Investigative Site
RECRUITING

Jerusalem, 9103102, Israel
Novartis Investigative Site
RECRUITING

Jerusalem, 9112001, Israel
Novartis Investigative Site
RECRUITING

Nahariya, 2210001, Israel
Novartis Investigative Site
RECRUITING

Petah Tikva, 4941492, Israel
Novartis Investigative Site
RECRUITING

Ramat Gan, 5265601, Israel
Novartis Investigative Site
RECRUITING

Tel Aviv, 6423906, Israel
Novartis Investigative Site
RECRUITING

Ancona, AN, 60126, Italy
Novartis Investigative Site
RECRUITING

Bergamo, BG, 24127, Italy
Novartis Investigative Site
WITHDRAWN

Bologna, BO, 40138, Italy
Novartis Investigative Site
RECRUITING

Brescia, BS, 25123, Italy
Novartis Investigative Site
RECRUITING

Caserta, CE, 81100, Italy
Novartis Investigative Site
RECRUITING

Cona, FE, 44124, Italy
Novartis Investigative Site
RECRUITING

Pozzilli, IS, 86077, Italy
Novartis Investigative Site
RECRUITING

Milan, MI, 20138, Italy
Novartis Investigative Site
RECRUITING

Milan, MI, 20157, Italy
Novartis Investigative Site
RECRUITING

Milan, MI, 20162, Italy
Novartis Investigative Site
RECRUITING

Padova, PD, 35128, Italy
Novartis Investigative Site
RECRUITING

Pordenone, PN, 33170, Italy
Novartis Investigative Site
RECRUITING

Amsterdam, North Holland, 1090 HM, Netherlands
Novartis Investigative Site
RECRUITING

Amsterdam, North Holland, 1105 AZ, Netherlands
Novartis Investigative Site
RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
Novartis Investigative Site
RECRUITING

Rotterdam, South Holland, 3079 DZ, Netherlands
Novartis Investigative Site
RECRUITING

Nieuwegein, Utrecht, 3435 CM, Netherlands
Novartis Investigative Site
RECRUITING

Alcabideche, 2755-009, Portugal
Novartis Investigative Site
RECRUITING

Braga, 4710243, Portugal
Novartis Investigative Site
RECRUITING

Coimbra, 3004-561, Portugal
Novartis Investigative Site
RECRUITING

Vila Nova de Gaia, 4434 502, Portugal
Novartis Investigative Site
RECRUITING

Cáceres, Extremadura, 10003, Spain
Novartis Investigative Site
RECRUITING

Córdoba, 14004, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28034, Spain
Novartis Investigative Site
WITHDRAWN

Madrid, 28040, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28041, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28046, Spain
Novartis Investigative Site
RECRUITING

Salamanca, 37007, Spain
Novartis Investigative Site
RECRUITING

Valencia, 46010, Spain
Novartis Investigative Site
RECRUITING

Basel, 4031, Switzerland
Novartis Investigative Site
RECRUITING

Geneva, 1211, Switzerland
Novartis Investigative Site
RECRUITING

Lausanne, 1011, Switzerland
Novartis Investigative Site
RECRUITING

Lugano, 6900, Switzerland
Novartis Investigative Site
WITHDRAWN

Zurich, 8091, Switzerland
Novartis Investigative Site
RECRUITING

Reading, Berkshire, RG1 5AN, United Kingdom
Novartis Investigative Site
RECRUITING

Portadown, Nothern Ireland, BT63 5QQ, United Kingdom
Novartis Investigative Site
RECRUITING

Edinburgh, EH16 4SA, United Kingdom
Novartis Investigative Site
RECRUITING

Leicester, LE3 9QP, United Kingdom
Novartis Investigative Site
RECRUITING

Liverpool, L14 3PE, United Kingdom
Novartis Investigative Site
RECRUITING

London, EC1A 7BE, United Kingdom
Novartis Investigative Site
RECRUITING

London, SE1 7EH, United Kingdom
Novartis Investigative Site
RECRUITING

Londonderry, BT47 6SB, United Kingdom
Novartis Investigative Site
RECRUITING

Manchester, M23 9LT, United Kingdom
Novartis Investigative Site
RECRUITING

Middlesbrough, TS4 3BW, United Kingdom
Novartis Investigative Site
RECRUITING

Norwich, NR4 7UY, United Kingdom
Novartis Investigative Site
RECRUITING

Tyne and Wear, NE29 8NH, United Kingdom
Ohio State University
WITHDRAWN

Columbus, Ohio, 43210, United States
Orion Medical
RECRUITING

Houston, Texas, 77034, United States
Overlook Medical Center
RECRUITING

Summit, New Jersey, 07901, United States
Perelman School of Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Stanford University Medical Center
RECRUITING

Palo Alto, California, 94304, United States
Strong Memorial Hospital
RECRUITING

Rochester, New York, 14642, United States
Texas Heart Institute
RECRUITING

Houston, Texas, 77030, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UC San Francisco Medical Center
RECRUITING

San Francisco, California, 94143, United States
University Of California San Diego
RECRUITING

San Diego, California, 92103-8415, United States
University Of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
Valley Clinical Trials
RECRUITING

Northridge, California, 91325, United States
Virginia Heart
RECRUITING

Falls Church, Virginia, 22042, United States
Wake Forest University Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
William Beaumont Hospital
RECRUITING

Royal Oak, Michigan, 48073-4192, United States

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