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New combo therapy aims to beat staph blood infections

NCT ID NCT06958835

Recruiting now Disease control Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests whether adding the antibiotic linezolid to standard treatment improves outcomes for people with Staphylococcus aureus bloodstream infections. About 606 hospitalized adults will receive either linezolid or a placebo for five days. The goal is to see if the combination reduces complications, helps patients return to normal function, and improves survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
linezolid
What this could lead to
If it works, this could lead to a better treatment strategy for serious staph bloodstream infections, reducing complications and improving survival.
What could go wrong
This is a mid-stage trial, so results may not confirm benefit. Adding linezolid also carries risks like side effects or drug interactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bacterial infectious disease with sepsis Sepsis staphylococcal infection staphylococcus aureus infection Toxemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAPHYLOCOCCUS AUREUS BLOODSTREAM INFECTIONS (BSI; BACTEREMIA)

Contacts and locations

Locations

  • Centre hospitalier universitaire vaudois (CHUV)

    RECRUITING

    Lausanne, Canton of Vaud, Switzerland

  • Ente Ospedaliero Cantonale (EOC)

    RECRUITING

    Lugano, Canton Ticino, Switzerland

  • HOCH Health Ostschweiz, Kantonsspital St.Gallen

    RECRUITING

    Sankt Gallen, Canton of St. Gallen, Switzerland

  • Hôpital du Jura

    RECRUITING

    Delémont, Canton of Jura, Switzerland

  • Hôpitaux universitaires de Genève (HUG)

    RECRUITING

    Geneva, Canton of Geneva, Switzerland

  • Inselspital Bern

    RECRUITING

    Bern, Canton of Bern, Switzerland

  • Kantonsspital Aarau (KSA)

    RECRUITING

    Aarau, Canton of Aargau, Switzerland

  • Kantonsspital Winterthur (KSW)

    RECRUITING

    Winterthur, Canton of Zurich, Switzerland

  • St. Claraspital

    RECRUITING

    Basel, Canton of Basel-City, Switzerland

  • Stadtspital Zürich Triemli

    RECRUITING

    Zurich, Canton of Zurich, Switzerland

  • University Hospital Basel (USB)

    RECRUITING

    Basel, 4031, Switzerland

  • Universitätsspital Zürich (USZ)

    RECRUITING

    Zurich, Canton of Zurich, Switzerland

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