University Hospital, Basel, Switzerland

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This study is testing two ways to perform a repeat ablation procedure in people with atrial fibrillation (an irregular heartbeat) that has returned after a first treatment. Both approaches use pulsed-field ablation to isolate the pulmonary veins, but one also adds ablation of the…

This pilot study tests a simple method to reduce wound complications after groin vascular surgery. Surgeons will inject a blue dye into the skin around the surgical wound to make any lymphatic leaks visible, then repair them immediately. The study will enroll 60 adults and track …

This early-phase trial tests a new type of CAR T cell therapy that targets two proteins (CD19 and CD20) on B cell cancer cells. It is for adults with B cell leukemia or lymphoma who have run out of standard options, including commercial CAR T cells. The main goal is to check safe…

This study tests a new program where trained village health workers use tablet-based tools to provide HIV prevention services, including PrEP and emergency PEP, to people at high risk in rural Lesotho. About 380 participants will be enrolled to see if this approach increases mont…

This study tests whether giving lorazepam, a sedative, can prevent delirium in intensive care patients who are at high risk due to heavy alcohol use. Researchers will use a blood test (Anttila-Index) to identify these patients. The trial involves 260 adults admitted to the ICU, w…

This study tests whether an IDO-1 inhibitor can safely prevent Epstein-Barr virus (EBV) infection in kidney transplant recipients who have never had EBV but receive a kidney from an EBV-positive donor. Nine participants will receive either the drug or a placebo for 28 days, along…

This trial investigates whether adding the non-opioid drugs metamizole (dipyrone) or ibuprofen to standard opioid therapy provides better pain relief for people with cancer-related pain. About 318 adults with advanced cancer and moderate to severe pain will receive either metamiz…

This study compares two total body photography systems used to screen for melanoma, a serious skin cancer. One system, Deviskan, takes automated images with non-contact dermoscopy, while the other, Vectra WB360, uses 3D photography with manual dermoscopy. Researchers will ask 60 …

This study is looking at whether levels of oxytocin, often called the 'love hormone,' differ between women before and after menopause. Researchers will measure a marker of oxytocin in the blood over a month in both groups. The goal is to understand how the body's oxytocin system …

This study tests a new wearable system called M2VS that measures heart activity (ECG) and blood pressure continuously for 24 hours. Researchers want to see if it works as well as standard monitors like Holter ECG and ambulatory blood pressure monitors. The study involves 20 adult…

This study compares a quick 3-step hand hygiene technique to the standard 6-step method recommended by the World Health Organization. Researchers want to see if the simpler method leads to better compliance among healthcare workers and still keeps hands clean. The trial will invo…

This study gives 40 adults—half with autism, half without—a single dose of MDMA (the active ingredient in ecstasy) or a placebo to see how it changes oxytocin levels in the blood. Oxytocin is often called the 'love hormone' and helps with social bonding. The goal is not to treat …

This small study with 12 adults checks if wearable temperature sensors can collect reliable data when compared to an ingestible capsule that measures core body temperature. Participants wear the sensors and swallow the capsule for about 48 hours. The goal is to see if the process…

This study surveys 200 ICU doctors in Switzerland to understand how they use ultrasound to manage fluids and check for vein congestion. The goal is to learn what doctors know and how often they use these techniques. No treatments or procedures are tested—just a questionnaire.