Can adding a second ablation target stop atrial fibrillation from coming back?

NCT ID NCT07745543

Not yet recruiting Disease control Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study is testing two ways to perform a repeat ablation procedure in people with atrial fibrillation (an irregular heartbeat) that has returned after a first treatment. Both approaches use pulsed-field ablation to isolate the pulmonary veins, but one also adds ablation of the back wall of the left atrium. The goal is to see which strategy better prevents any atrial arrhythmia from recurring within a year, using an implantable monitor to track heart rhythm continuously.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pulsed-field ablation procedure (pulmonary vein isolation with or without posterior wall ablation)
What this could lead to: If successful, this could identify the more effective ablation strategy for people with atrial fibrillation who need a repeat procedure, potentially reducing the chance of the arrhythmia returning.
What could go wrong: This is a randomized trial, but results are not yet available. The added posterior wall ablation may not improve outcomes and could carry extra risks, such as damage to nearby structures like the phrenic nerve.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF)

Contacts and locations

Locations

Bern University Hospital

Bern, 3010, Switzerland
Cantonal Hospital of St. Gallen

Sankt Gallen, 9007, Switzerland
University Hospital Basel

Basel, 4031, Switzerland
University Hospital Lausanne

Lausanne, 1011, Switzerland
University Hospital Zurich,

Zurich, 8091, Switzerland

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