Could common painkillers boost opioid effectiveness for cancer patients?
NCT ID NCT07682558
First seen Jul 06, 2026 · Last updated Jul 08, 2026 · Updated 2 times
Summary
This trial investigates whether adding the non-opioid drugs metamizole (dipyrone) or ibuprofen to standard opioid therapy provides better pain relief for people with cancer-related pain. About 318 adults with advanced cancer and moderate to severe pain will receive either metamizole, ibuprofen, or a placebo alongside their opioid treatment. The study measures changes in average daily pain over one week to see if the combination approach is more effective than opioids alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Metamizole (dipyrone) and ibuprofen
- What this could lead to
- If it works, this could provide a safer, more effective way to manage cancer pain by combining non-opioid drugs with opioids.
- What could go wrong
- This is a Phase 3 trial, but results may not apply to all cancer patients. Side effects from metamizole or ibuprofen are possible, and the drugs may not prove more effective than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CANCER PAIN are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
University Hospital Basel
Basel, 4031, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New Low-Dose pain patch aims to ease cancer suffering
- Radiosurgery zaps cancer pain when opioids fail
- Can video calls replace clinic visits for cancer pain?
- Massage therapy may ease painful sex after gynecological cancer
- New app aims to ease cancer pain for rural patients
- New study seeks best way to block cancer pain without drugs