Could a single radiation dose ease bone pain as well as five?
NCT ID NCT07772206
First seen Aug 19, 2026 · Last updated Aug 19, 2026
Summary
This trial is testing whether a single, higher dose of radiation (8 Gy) can relieve pain from bone metastases as effectively as a standard course of five smaller doses (20 Gy total). The study includes adults with cancer that has spread to the bones and who have significant pain. The main goal is to see if this approach is practical and acceptable to patients, while also checking pain relief, side effects, and the need for repeat treatment. The results will help design a larger study to confirm the best way to deliver palliative radiotherapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Radiotherapy (single-fraction 8 Gy vs multifraction 20 Gy in 5 fractions)
- What this could lead to
- If successful, this could show that a single radiation session is as effective as multiple sessions for easing bone pain, making treatment faster and more convenient for patients.
- What could go wrong
- This is a small feasibility study, not a large definitive trial, so results may not be conclusive. There are risks of pain flare or side effects from radiation, and the single dose may not control pain as well as multiple doses.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Royal Hospital
Muscat, Muḩāfaz̧at Masqaţ, 100, Oman
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