Istituto Ortopedico Rizzoli

This study tests whether carbon fiber screws work as well as titanium ones for spinal fusion in people with degenerative disc disease. Carbon fiber allows clearer MRI and CT scans after surgery, which may help doctors monitor healing better. About 118 adults needing one or two le…

This study is testing a treatment called electrosclerotherapy for people with low-flow venous malformations (abnormal blood vessels present from birth). The goal is to shrink the malformation by at least 30% and reduce pain. About 65 participants will receive the treatment and be…

This study looks at how well a short, bone-friendly stem works for total hip replacement when done through a front-of-hip incision. Researchers will follow 400 adults with hip arthritis for at least two years to check implant survival, complications, pain, and recovery. The goal …

This study is for people with symptomatic desmoid tumors that are growing and cannot be treated with surgery or freezing. Researchers are testing a procedure that delivers chemotherapy (doxorubicin) directly into the tumor through a small tube in an artery, aiming to shrink the t…

This pilot study is testing a custom-made, 3D-printed titanium implant that replaces the ankle joint and talus bone in people with severe bone loss or damage. The implant is designed to fit each patient perfectly and aims to preserve ankle function while reducing surgical harm to…

This study follows 20 people who had surgery as children to correct flatfoot. Researchers want to see if the correction lasts more than 10 years by checking foot structure and pain. They use simple tests like standing on tiptoes and X-rays to measure results.

This pilot study compares two types of keyhole surgery for hallux valgus, commonly known as bunions. Forty adults with moderate bunions will be randomly assigned to one of two procedures: one using a wire to stabilize the bone, the other using two small screws. The goal is to see…

This study tests a new hip replacement device coated with silver to see if it can prevent infections in people at high risk, such as those with diabetes or weak immune systems. About 70 participants will receive the implant and be followed for infection rates and silver safety. T…

This pilot study tests a new surgical technique for people with large ankle cartilage and bone defects. Surgeons will drill into the damaged bone and place a scaffold enriched with the patient's own bone marrow cells to help regenerate tissue. The goal is to see if this approach …

This study tests custom-made, 3D-printed hip implants for 15 adults whose previous hip replacements failed due to severe bone loss or infection. The implants are designed from CT scans to fit each person's unique bone damage. Researchers will track complications, pain, mobility, …

This study tests whether a single injection of cells from your own bone marrow or belly fat can better ease knee osteoarthritis pain and stiffness. 204 adults aged 40-75 with knee OA will be randomly assigned to one of the two treatments. The goal is to see which cell source work…

This study tests a new surgical approach for people with large rotator cuff tears. Doctors will use a special skin tissue (donated and processed to remove cells) combined with the patient's own bone marrow and shoulder lining cells to strengthen the repair. The goal is to see if …

This study is testing an osteointegrated implant for people with leg amputations. Instead of a traditional socket that can cause skin problems, a metal stem is anchored directly to the bone. Researchers will measure quality of life and mobility in 15 participants to see if this a…

This study follows 150 people with knee osteoarthritis and leg misalignment who had a knee osteotomy—a surgery that realigns the bones to take pressure off the damaged part of the knee. Researchers want to see how well the knee works years later and whether this surgery can help …

This study tests whether custom-made ankle implants, designed from each patient's CT scans, work better than standard implants for ankle osteoarthritis. About 24 adults aged 40-75 will receive either a custom or standard implant. Researchers will check bone alignment on X-rays, p…

This study tests whether injecting a patient's own fat tissue along with hyaluronic acid into one knee works better than fat alone in the other knee. One hundred adults with painful knee osteoarthritis will receive both treatments, and researchers will compare pain, stiffness, an…

This study compares two knee surgeries for people with knee osteoarthritis, a meniscus problem, and a misaligned leg. Half the participants will get a standard realignment surgery, and the other half will get that plus a donor meniscus transplant. The goal is to see if the combin…

This study looks at a new surgical method for treating meniscal root tears, which can lead to knee arthritis if not fixed. The surgery stitches the torn meniscus root to a knee ligament without needing special planning before the operation. About 59 people aged 18 to 50 who have …

This study looks at whether blocking the blood supply to desmoid tumors (using tiny particles injected into the arteries) can shrink the tumor and reduce pain without using chemotherapy. It will follow 20 people aged 12 and older who have painful, growing desmoid tumors that cann…

This study is testing a new blood-based method to diagnose osteoporosis and predict fracture risk. Researchers will analyze the vitality and behavior of certain blood cells from 120 healthy, osteopenic, and osteoporotic adults aged 40 and older. The goal is to see if this approac…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study tests two simple physical exam techniques to see if they can accurately diagnose chronic plantar fasciopathy, a common cause of heel pain. Researchers will compare these tests in 45 adults—some with the condition and some without—to measure how well they work. If prove…

This study looks at whether combining blood and joint fluid tests can more accurately diagnose infections in people who need a second hip or knee replacement. Researchers will test 270 patients and compare the accuracy and cost of different markers. The goal is to help doctors de…

This study tests different strategies to prevent foot ulcers in people with type-2 diabetes. It includes 150 adults who are either at mild-to-moderate risk of developing a foot ulcer or have had one that healed at least 6 months ago. Researchers will check blood markers of inflam…

This study compares two approaches to recovery after total knee replacement: a fast track plan designed to speed up recovery versus standard care. Researchers will measure how well patients can move and care for themselves after surgery, as well as how long they stay in the hospi…

This study looks at whether a procedure called arterial embolization can reduce pain and improve quality of life in people with bone metastases (cancer that has spread to the bones). The procedure blocks blood flow to the tumor, which may shrink it and ease symptoms. Researchers …

This study tests whether using a virtual reality headset for 20 minutes before a CT-guided biopsy can lower anxiety. About 236 adults will be randomly assigned to either use VR plus standard care or standard care alone. Researchers will measure anxiety with questionnaires before …

This pilot study compares custom-made, 3D-printed knee implants (YourKnee) to standard off-the-shelf implants in 20 people with knee osteoarthritis. The custom implants are designed based on each patient's unique knee shape and are placed using patient-specific cutting guides. Th…

This study looks at 134 people with De Quervain's disease, a painful thumb tendon condition. All participants get a steroid injection, then either standard physiotherapy or a program of eccentric exercises. The goal is to see which approach better reduces pain and improves hand f…

This study is testing whether using a special sensor device during knee replacement surgery leads to better results for patients. The device helps the surgeon make precise bone cuts. Researchers will follow 40 people for up to 2 years after surgery, measuring pain, function, and …

This study tests a procedure called transarterial microembolization (TAME) for people with knee osteoarthritis and long-lasting pain that hasn't improved with standard treatments. Doctors will inject tiny beads into blood vessels around the knee to block abnormal blood flow, aimi…

This study compares a mix of telerehabilitation (10 remote sessions) plus in-person physiotherapy against standard in-person rehab (16 sessions) for people who have had a total hip replacement. Researchers will measure pain, function, and patient satisfaction in 104 adults aged 5…

This study tests whether virtual reality (VR) can reduce anxiety and pain in children aged 7 to 12 during minor orthopedic surgery. Half the children will use a VR headset with calming scenes before and during surgery, while the other half receive standard sedative medication. Re…

This study tests whether a combination of platelet-rich plasma (PRP) and hyaluronic acid injections works better than either treatment alone for knee osteoarthritis. About 288 adults aged 40 to 75 with knee pain will receive one of three treatments. The goal is to see if the comb…

This study tests whether a single injection of collagen into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare the collagen injection to a placebo (saline) injection in 204 adults. The main goal is to see if collagen …

This study compares a new tensioner device to standard surgical techniques for knee replacement. The goal is to see if the tensioner helps surgeons better balance the ligaments, leading to a more stable knee and less pain. Two hundred patients will be randomly assigned to receive…

This study compares online physiotherapy (telerehabilitation) with standard in-person sessions for people who have had arthroscopic rotator cuff repair surgery. The goal is to see if the online option works just as well for reducing pain, improving shoulder movement, and helping …

This study compares two common knee injections—platelet-rich plasma (PRP) and hyaluronic acid (HA)—for treating osteoarthritis behind the kneecap. About 166 adults aged 30–65 will receive a single injection and be followed for 12 months to see which provides better pain relief an…

This study tests whether injecting platelet-rich plasma (PRP) into the elbow can reduce pain and improve function in people with tennis elbow that hasn't gotten better with other treatments. 240 adults will receive either PRP with white blood cells, PRP without white blood cells,…

This study tests two versions of platelet-rich plasma (PRP) injections—one with white blood cells and one without—to see which better reduces pain and stiffness in people with hip osteoarthritis. About 230 adults with mild to moderate hip OA will receive ultrasound-guided injecti…

This study compares two ways to perform total knee replacement: the standard manual technique versus one guided by computer-assisted navigation. Researchers will enroll 160 patients and measure pain, function, blood loss, and costs. The goal is to see if the computer-assisted met…

This study will follow 78 people aged 50 to 85 who need a total knee replacement to see how well a newer all-polyethylene (plastic) knee implant holds up over 5 years. Researchers want to know if this design, which may be cheaper and have fewer mechanical problems, works as well …

This study aims to create a computer model that can predict how soon patients will walk on their own after hip or knee replacement surgery. Researchers will collect data from about 943 patients who had surgery and physical therapy. The goal is to help doctors plan better care, bu…

This study compares two ways of tracking recovery after knee replacement surgery: traditional paper questionnaires filled out at the clinic versus digital surveys sent to a patient's smartphone. Researchers will enroll 50 adults aged 18-78 who own a smartphone, tablet, or compute…

This study looks at how well people recover at least two years after surgery for a torn biceps tendon. Researchers will check elbow function, strength, and take X-rays to see if any complications like bone growth have occurred. The goal is to better understand long-term results a…

This study looks at how major spine surgery damages the protective lining of blood vessels, called the glycocalyx. Researchers will measure a substance called Syndecan-1 in the blood of 30 people before and after surgery. The goal is to understand the extent of this damage and se…

This study is recruiting 100 people who need hip replacement surgery after a fragility fracture (a break from a minor fall) and comparing them to patients having hip replacement for arthritis. Researchers will use a simple questionnaire (SARC-F) and analyze bone and muscle tissue…

This study tests whether using a smartphone app (Google Forms) to fill out recovery questionnaires after hip replacement is as good as the traditional paper method. Researchers will compare how many patients complete the digital survey on time versus the paper one. The goal is to…

This study reviews the medical records of 300 people with multiple osteochondromas (a rare bone condition causing multiple bony growths) who had surgery at a specialized hospital in Italy. Researchers want to understand how many surgeries patients typically need, what types of su…

This study looks at whether a detailed MRI analysis called radiomics can predict if a desmoid tumor will grow back after cryoablation (freezing treatment) better than standard methods. Researchers will follow 21 patients treated at one hospital to compare radiomics with usual siz…

This study looks back at the medical records of over 200 people with fibrous dysplasia, a rare bone condition that causes abnormal growths. Researchers want to learn more about the disease's features, treatments, and genetic causes. No new treatments are being tested; the goal is…

This study looks at how bone density changes around two types of knee replacement implants over two years. About 50 people getting a cemented total knee replacement will join. Researchers will use special X-rays to measure bone loss and track how well the knee works. The goal is …

This study measures how loose the knee is during surgery for ACL reconstruction, ACL revision, or meniscus transplantation. Researchers use a navigation system and a special device to track knee movement in real time. The goal is to gather data that may help improve surgical tech…

This study looks at how multiple osteochondromas (non-cancerous bone growths) affect movement and body shape in children and adults. Researchers will use wearable sensors, pressure mats, and 3D body scans to measure walking, balance, and joint motion. The goal is to find simple w…

This study looks at whether muscle power and control can predict falls better than muscle strength in people aged 65-80 with knee osteoarthritis. Fifty participants will undergo muscle tests, walking analysis, and MRI scans. The goal is to develop a fall-risk assessment tool for …

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) for early knee arthritis. Researchers want to see how the surgery affects the kneecap joint and arthritis progression over the long term. Participants are under 65 and had the surgery at least 5…

This study looks at how pain and the ability to walk change in the first days after a limb amputation. Researchers will review medical records of 150 adults to see how pain levels and recovery are linked to patient details and treatments. The goal is to find patterns that could h…

This study looks at how well bone cancer patients follow a personalized home exercise program in the first six months after lower leg surgery. Researchers will track daily exercise logs from 50 patients and explore what factors help or hinder adherence. The goal is to learn how t…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well dissolving screws work to fix broken cartilage pieces in the knees of people aged 12 to 35. The goal is to see if this surgery helps prevent long-term problems like pain, stiffness, and early arthritis. Researchers will track symptoms and daily functi…

This study looks at whether the Iowa Level of Assistance (ILoA) scale is a reliable tool for measuring functional recovery in patients after joint replacement surgery. Researchers will have multiple physiotherapists assess the same patients to see if their scores agree. The goal …

This study looks at how well a dissolvable implant placed in the foot joint of children and teens (ages 8-15) works after at least 5 years. Researchers will use MRI scans and foot function scores to see if the implant has dissolved properly and if patients are doing well. The goa…

This study aims to create and test an Italian version of a standard knee questionnaire, the New Knee Society Knee Scoring System. Researchers will translate the English survey into Italian, check its accuracy, and then ask about 300 Italian patients with knee osteoarthritis to fi…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 1,000 children with lower limb deformities (like bowed legs or leg length differences) to better understand their conditions and treatments. Researchers will use questionnaires and physical exams to track outcomes over time. The goal is to create a standard way…

This study aims to understand why some people have complications after spinal surgery. Researchers will measure bone strength, muscle health, and other markers in 200 adults undergoing spine surgery. The goal is to find better ways to predict and prevent problems like pain or the…

This study is observing 40 people with osteogenesis imperfecta (brittle bone disease) to see how often heart problems occur. Researchers will use standard heart tests like echocardiograms to check for issues. The goal is to create better screening guidelines to catch heart proble…

This study is creating a registry for people with Li-Fraumeni syndrome, a rare genetic condition that raises the risk of several cancers. Researchers will collect medical, genetic, and quality-of-life data from 200 participants in Italy. The goal is to better understand the disea…

This observational study is tracking 150 people whose high-grade osteosarcoma has come back near where it started. Researchers want to find out what factors affect how long people live after this type of relapse. The study will look at past and future cases to gather information …

This study is testing a special scaffold designed to help repair damaged knee cartilage in people with osteochondritis dissecans. The scaffold is implanted during surgery to support new tissue growth. Researchers will follow 30 patients aged 15-40 to see how their knee symptoms, …

This study is developing a new way to deliver chemotherapy directly to sarcoma tumors using tiny particles activated by light through an optic fiber. Researchers will test these nanoparticles on cells and tissue samples from 30 patients with bone or soft tissue sarcomas. The goal…