New blood and joint fluid tests aim to spot hidden infections after joint replacement

NCT ID NCT04858217

Recruiting now Diagnosis Sponsor: Istituto Ortopedico Rizzoli Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at whether combining blood and joint fluid tests can more accurately diagnose infections in people who need a second hip or knee replacement. Researchers will test 270 patients and compare the accuracy and cost of different markers. The goal is to help doctors decide the best surgical approach faster and avoid unnecessary treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to faster, more accurate diagnosis of joint replacement infections, helping doctors choose the right surgery sooner.
What could go wrong: This is an observational study, not a treatment trial. The markers may not prove reliable enough to change current practice, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periprosthetic joint infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTHETIC-JOINT INFECTION

Contacts and locations

Locations

IRCCS Istituto Ortopedico Rizzoli
RECRUITING

Bologna, 40134, Italy

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